Effect of Oral Pregabalin as Preemptive Analgesic in Patients Undergoing Lower Limb Orthopedic Surgeries under Spinal Anaesthesia
Introduction: Conquering postoperative pain which has significant impact on the surgery outcome can be challenging for the clinicians. Pregabalin is a GABA analogue used for various neuropathic pain syndromes. Very few studies are there with the use of pregabalin as a preemptive analgesic for or...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-07-01
|
| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/8081/18854_CE(RA1)_F(T)_PF1(VSUAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Introduction: Conquering postoperative pain which has
significant impact on the surgery outcome can be challenging for
the clinicians. Pregabalin is a GABA analogue used for various
neuropathic pain syndromes. Very few studies are there with
the use of pregabalin as a preemptive analgesic for orthopedic
surgeries.
Aim: To compare pregabalin 150 mg with placebo for
postoperative pain control in patients undergoing elective lower
limb orthopedic surgeries under spinal anaesthesia and to
assess any side effects.
Materials and Methods: A randomized double blinded prospective study was undertaken. Ninety patients with ASA physical
status I, II, aged between 18–50 years were enrolled in the
study. One hour prior to spinal anaesthesia Group C - received
colour matched empty capsules, Group P – received 150mg of
oral pregabalin. Spinal anaesthesia was administered in sitting
position in L3-L4 space with Inj. Bupivacaine heavy (0.5%) at a
dose of 0.3mg/kg body weight with 20 mg being the maximum
dose using 25 gauge spinal needle. Rescue analgesia was
provided with using Inj. Diclofenac 1.5 mg/kg intramuscular.
Results: Time for rescue analgesia (VAS score >3) was
significantly increased in Group P than in Group C. The total
dose of diclofenac required in the 24 hour postoperative period
was significantly lower in Group P than in Group C. The sedation
scores and patient satisfaction scores were also more in Group
P than in Group C.
Conclusion: Preemptive pregabalin in an oral dose of 150 mg
offers good postoperative analgesia in lower limb orthopedic
surgeries under spinal anaesthesia. |
|---|---|
| ISSN: | 2249-782X 0973-709X |