Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer
During colorectal inflammation and cancer, myeloid cells accumulate in the spleen and suppress the host immunity response. In this study, the authors use a mouse model of colitis to demonstrate that upon vagus stimulation splenic memory T cells release TFF2, which suppresses the expansion of myeloid...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms10517 |
| _version_ | 1830288015025504256 |
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| author | Zina Dubeykovskaya Yiling Si Xiaowei Chen Daniel L. Worthley Bernhard W. Renz Aleksandra M. Urbanska Yoku Hayakawa Ting Xu C. Benedikt Westphalen Alexander Dubeykovskiy Duan Chen Richard A. Friedman Samuel Asfaha Karan Nagar Yagnesh Tailor Sureshkumar Muthupalani James G. Fox Jan Kitajewski Timothy C. Wang |
| author_facet | Zina Dubeykovskaya Yiling Si Xiaowei Chen Daniel L. Worthley Bernhard W. Renz Aleksandra M. Urbanska Yoku Hayakawa Ting Xu C. Benedikt Westphalen Alexander Dubeykovskiy Duan Chen Richard A. Friedman Samuel Asfaha Karan Nagar Yagnesh Tailor Sureshkumar Muthupalani James G. Fox Jan Kitajewski Timothy C. Wang |
| author_sort | Zina Dubeykovskaya |
| collection | DOAJ |
| description | During colorectal inflammation and cancer, myeloid cells accumulate in the spleen and suppress the host immunity response. In this study, the authors use a mouse model of colitis to demonstrate that upon vagus stimulation splenic memory T cells release TFF2, which suppresses the expansion of myeloid cells and cancer progression. |
| first_indexed | 2024-12-19T04:28:11Z |
| format | Article |
| id | doaj.art-67d8a761a2b64f5c8b8c4095b1685dfc |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:28:11Z |
| publishDate | 2016-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-67d8a761a2b64f5c8b8c4095b1685dfc2022-12-21T20:35:58ZengNature PortfolioNature Communications2041-17232016-02-017111110.1038/ncomms10517Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancerZina Dubeykovskaya0Yiling Si1Xiaowei Chen2Daniel L. Worthley3Bernhard W. Renz4Aleksandra M. Urbanska5Yoku Hayakawa6Ting Xu7C. Benedikt Westphalen8Alexander Dubeykovskiy9Duan Chen10Richard A. Friedman11Samuel Asfaha12Karan Nagar13Yagnesh Tailor14Sureshkumar Muthupalani15James G. Fox16Jan Kitajewski17Timothy C. Wang18Division of Digestive and Liver Disease, Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia UniversityDivision of Digestive and Liver Disease, Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia UniversityDivision of Digestive and Liver Disease, Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia UniversityDivision of Digestive and Liver Disease, Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia UniversityDivision of Digestive and Liver Disease, Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia UniversityDivision of Digestive and Liver Disease, Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia UniversityDivision of Digestive and Liver Disease, Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia UniversityDivision of Digestive and Liver Disease, Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia UniversityDivision of Digestive and Liver Disease, Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia UniversityDivision of Digestive and Liver Disease, Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia UniversityDepartment of Cancer Research and Molecular Medicine, Norwegian University of Science and TechnologyDepartment of Biomedical Informatics, Irving Cancer Research Center, Columbia UniversityDivision of Digestive and Liver Disease, Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia UniversityDivision of Digestive and Liver Disease, Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia UniversityDivision of Digestive and Liver Disease, Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia UniversityDepartment of Biological Engineering, Division of Comparative Medicine, Massachusetts Institute of TechnologyDepartment of Biological Engineering, Division of Comparative Medicine, Massachusetts Institute of TechnologyDepartment of Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, Columbia UniversityDivision of Digestive and Liver Disease, Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia UniversityDuring colorectal inflammation and cancer, myeloid cells accumulate in the spleen and suppress the host immunity response. In this study, the authors use a mouse model of colitis to demonstrate that upon vagus stimulation splenic memory T cells release TFF2, which suppresses the expansion of myeloid cells and cancer progression.https://doi.org/10.1038/ncomms10517 |
| spellingShingle | Zina Dubeykovskaya Yiling Si Xiaowei Chen Daniel L. Worthley Bernhard W. Renz Aleksandra M. Urbanska Yoku Hayakawa Ting Xu C. Benedikt Westphalen Alexander Dubeykovskiy Duan Chen Richard A. Friedman Samuel Asfaha Karan Nagar Yagnesh Tailor Sureshkumar Muthupalani James G. Fox Jan Kitajewski Timothy C. Wang Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer Nature Communications |
| title | Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer |
| title_full | Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer |
| title_fullStr | Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer |
| title_full_unstemmed | Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer |
| title_short | Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer |
| title_sort | neural innervation stimulates splenic tff2 to arrest myeloid cell expansion and cancer |
| url | https://doi.org/10.1038/ncomms10517 |
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