Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer

Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer

During colorectal inflammation and cancer, myeloid cells accumulate in the spleen and suppress the host immunity response. In this study, the authors use a mouse model of colitis to demonstrate that upon vagus stimulation splenic memory T cells release TFF2, which suppresses the expansion of myeloid...

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Detalhes bibliográficos
Main Authors: Zina Dubeykovskaya, Yiling Si, Xiaowei Chen, Daniel L. Worthley, Bernhard W. Renz, Aleksandra M. Urbanska, Yoku Hayakawa, Ting Xu, C. Benedikt Westphalen, Alexander Dubeykovskiy, Duan Chen, Richard A. Friedman, Samuel Asfaha, Karan Nagar, Yagnesh Tailor, Sureshkumar Muthupalani, James G. Fox, Jan Kitajewski, Timothy C. Wang
Formato: Artigo
Idioma:English
Publicado em: Nature Portfolio 2016-02-01
Colecção:Nature Communications
Acesso em linha:https://doi.org/10.1038/ncomms10517

Internet

https://doi.org/10.1038/ncomms10517

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