Oral administration of alanyl-glutamine and glutamine improve random pattern dorsal skin flap survival in rats
Objective(s): Skin flap necrosis is the most common postoperative side effect in reconstructive surgeries. Glutamine (GLN) has been shown to accelerate wound healing process. The purpose of this study was to evaluate the effects of GLN either in free form or in the dipeptide form along with L- alany...
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| Language: | English |
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Mashhad University of Medical Sciences
2018-08-01
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| Series: | Iranian Journal of Basic Medical Sciences |
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| Online Access: | http://ijbms.mums.ac.ir/article_11077_4d7a1cd8eb264393c76e45ebc417f261.pdf |
| _version_ | 1811282024895348736 |
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| author | Mojtaba Karimpour Morteza Hassanzadeh Masoumeh Zirak Javanmard Gholam Hossein Farjah |
| author_facet | Mojtaba Karimpour Morteza Hassanzadeh Masoumeh Zirak Javanmard Gholam Hossein Farjah |
| author_sort | Mojtaba Karimpour |
| collection | DOAJ |
| description | Objective(s): Skin flap necrosis is the most common postoperative side effect in reconstructive surgeries. Glutamine (GLN) has been shown to accelerate wound healing process. The purpose of this study was to evaluate the effects of GLN either in free form or in the dipeptide form along with L- alanyl (Ala-GLN) on random skin flaps survival in rats.Materials and Methods: Dorsal skin flaps with caudal bases (8 ×2 cm) were established in 24 adult male Wistar rats. Then, the animals were randomly assigned into 3 groups (n=8). Control, GLN (0.75 g/kg) and Ala-GLN (0.75 g/kg). All groups administrated orally 24 and 6 hr before flap elevation and continued repeatedly daily until 7 days postoperation. The flap survival rate and vascular density using histological analysis were evaluated. Vascular endothelial growth factor (VEGF) by immunohistochemical method was determined.Results: Seven days after surgery, the mean surviving area in the GLN and Ala-GLN groups were significantly greater than in the untreated control group (P |
| first_indexed | 2024-04-13T01:45:08Z |
| format | Article |
| id | doaj.art-67dafbfe2a8d4404bf218d5df5712355 |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-04-13T01:45:08Z |
| publishDate | 2018-08-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-67dafbfe2a8d4404bf218d5df57123552022-12-22T03:08:04ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742018-08-0121884284710.22038/ijbms.2018.29629.715311077Oral administration of alanyl-glutamine and glutamine improve random pattern dorsal skin flap survival in ratsMojtaba Karimpour0Morteza Hassanzadeh1Masoumeh Zirak Javanmard2Gholam Hossein Farjah3Department of Anatomy, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, IranDepartment of Anatomy, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, IranDepartment of Anatomy, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, IranNeurophysiology Research Center, Department of Anatomy, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, IranObjective(s): Skin flap necrosis is the most common postoperative side effect in reconstructive surgeries. Glutamine (GLN) has been shown to accelerate wound healing process. The purpose of this study was to evaluate the effects of GLN either in free form or in the dipeptide form along with L- alanyl (Ala-GLN) on random skin flaps survival in rats.Materials and Methods: Dorsal skin flaps with caudal bases (8 ×2 cm) were established in 24 adult male Wistar rats. Then, the animals were randomly assigned into 3 groups (n=8). Control, GLN (0.75 g/kg) and Ala-GLN (0.75 g/kg). All groups administrated orally 24 and 6 hr before flap elevation and continued repeatedly daily until 7 days postoperation. The flap survival rate and vascular density using histological analysis were evaluated. Vascular endothelial growth factor (VEGF) by immunohistochemical method was determined.Results: Seven days after surgery, the mean surviving area in the GLN and Ala-GLN groups were significantly greater than in the untreated control group (Phttp://ijbms.mums.ac.ir/article_11077_4d7a1cd8eb264393c76e45ebc417f261.pdfAlanyl-glutamineFlapGlutamineRatsSurvivalVEGF |
| spellingShingle | Mojtaba Karimpour Morteza Hassanzadeh Masoumeh Zirak Javanmard Gholam Hossein Farjah Oral administration of alanyl-glutamine and glutamine improve random pattern dorsal skin flap survival in rats Iranian Journal of Basic Medical Sciences Alanyl-glutamine Flap Glutamine Rats Survival VEGF |
| title | Oral administration of alanyl-glutamine and glutamine improve random pattern dorsal skin flap survival in rats |
| title_full | Oral administration of alanyl-glutamine and glutamine improve random pattern dorsal skin flap survival in rats |
| title_fullStr | Oral administration of alanyl-glutamine and glutamine improve random pattern dorsal skin flap survival in rats |
| title_full_unstemmed | Oral administration of alanyl-glutamine and glutamine improve random pattern dorsal skin flap survival in rats |
| title_short | Oral administration of alanyl-glutamine and glutamine improve random pattern dorsal skin flap survival in rats |
| title_sort | oral administration of alanyl glutamine and glutamine improve random pattern dorsal skin flap survival in rats |
| topic | Alanyl-glutamine Flap Glutamine Rats Survival VEGF |
| url | http://ijbms.mums.ac.ir/article_11077_4d7a1cd8eb264393c76e45ebc417f261.pdf |
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