Glia Crosstalk in Neuroinflammatory Diseases
Neuroinflammation constitutes a fundamental cellular process to signal the loss of brain homeostasis. Glial cells play a central role in orchestrating these neuroinflammation processes in both deleterious and beneficial ways. These cellular responses depend on their intercellular interactions with n...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-07-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2020.00209/full |
| _version_ | 1819145572121051136 |
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| author | Ada Bernaus Sandra Blanco Sandra Blanco Ana Sevilla |
| author_facet | Ada Bernaus Sandra Blanco Sandra Blanco Ana Sevilla |
| author_sort | Ada Bernaus |
| collection | DOAJ |
| description | Neuroinflammation constitutes a fundamental cellular process to signal the loss of brain homeostasis. Glial cells play a central role in orchestrating these neuroinflammation processes in both deleterious and beneficial ways. These cellular responses depend on their intercellular interactions with neurons, astrocytes, the blood–brain barrier (BBB), and infiltrated T cells in the central nervous system (CNS). However, this intercellular crosstalk seems to be activated by specific stimuli for each different neurological scenario. This review summarizes key studies linking neuroinflammation with certain neurodegenerative diseases such as Alzheimer disease (AD), Parkinson disease (PD), and amyotrophic lateral sclerosis (ALS) and for the development of better therapeutic strategies based on immunomodulation. |
| first_indexed | 2024-12-22T13:00:09Z |
| format | Article |
| id | doaj.art-67dc094529db4c5bb4e08d72fc6fbb99 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-22T13:00:09Z |
| publishDate | 2020-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-67dc094529db4c5bb4e08d72fc6fbb992022-12-21T18:25:01ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022020-07-011410.3389/fncel.2020.00209539179Glia Crosstalk in Neuroinflammatory DiseasesAda Bernaus0Sandra Blanco1Sandra Blanco2Ana Sevilla3Departament de Biologia Cellular, Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona, Barcelona, SpainMolecular Mechanisms Program, Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC), University of Salamanca, Salamanca, SpainInstituto de Investigación Biomédica de Salamanca (IBSAL), Hospital Universitario de Salamanca, Salamanca, SpainDepartament de Biologia Cellular, Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona, Barcelona, SpainNeuroinflammation constitutes a fundamental cellular process to signal the loss of brain homeostasis. Glial cells play a central role in orchestrating these neuroinflammation processes in both deleterious and beneficial ways. These cellular responses depend on their intercellular interactions with neurons, astrocytes, the blood–brain barrier (BBB), and infiltrated T cells in the central nervous system (CNS). However, this intercellular crosstalk seems to be activated by specific stimuli for each different neurological scenario. This review summarizes key studies linking neuroinflammation with certain neurodegenerative diseases such as Alzheimer disease (AD), Parkinson disease (PD), and amyotrophic lateral sclerosis (ALS) and for the development of better therapeutic strategies based on immunomodulation.https://www.frontiersin.org/article/10.3389/fncel.2020.00209/fullneurodegenerationastrogliosismicrogliaproteinopathiesAlzheimer diseaseParkinson disease |
| spellingShingle | Ada Bernaus Sandra Blanco Sandra Blanco Ana Sevilla Glia Crosstalk in Neuroinflammatory Diseases Frontiers in Cellular Neuroscience neurodegeneration astrogliosis microglia proteinopathies Alzheimer disease Parkinson disease |
| title | Glia Crosstalk in Neuroinflammatory Diseases |
| title_full | Glia Crosstalk in Neuroinflammatory Diseases |
| title_fullStr | Glia Crosstalk in Neuroinflammatory Diseases |
| title_full_unstemmed | Glia Crosstalk in Neuroinflammatory Diseases |
| title_short | Glia Crosstalk in Neuroinflammatory Diseases |
| title_sort | glia crosstalk in neuroinflammatory diseases |
| topic | neurodegeneration astrogliosis microglia proteinopathies Alzheimer disease Parkinson disease |
| url | https://www.frontiersin.org/article/10.3389/fncel.2020.00209/full |
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