Role of electrolyte abnormalities and unmeasured anions in the metabolic acid‐base abnormalities in dogs with parvoviral enteritis
Abstract Background The strong ion model (SIM) is an alternative paradigm in the characterization of acid‐base disturbances particularly in complex disorders. Hypothesis/Objectives To compare the acid‐base changes in dogs with parvoviral enteritis (PE) using the Henderson‐Hasselbalch (HH) approach,...
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| Format: | Article |
| Language: | English |
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Wiley
2020-03-01
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| Series: | Journal of Veterinary Internal Medicine |
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| Online Access: | https://doi.org/10.1111/jvim.15749 |
| _version_ | 1818283060323418112 |
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| author | Richard K. Burchell Arnon Gal Ryan Friedlein Andrew L. Leisewitz |
| author_facet | Richard K. Burchell Arnon Gal Ryan Friedlein Andrew L. Leisewitz |
| author_sort | Richard K. Burchell |
| collection | DOAJ |
| description | Abstract Background The strong ion model (SIM) is an alternative paradigm in the characterization of acid‐base disturbances particularly in complex disorders. Hypothesis/Objectives To compare the acid‐base changes in dogs with parvoviral enteritis (PE) using the Henderson‐Hasselbalch (HH) approach, with 2 strong ion approaches. Animals Forty‐four dogs with PE, and 16 age‐matched control dogs. Methods Prospective controlled observational study. Acid‐base status was evaluated using the HH model, Fencl‐Stewart (FS) approach and a validated strong ion model (VDM). The acid‐base changes according to each model were classified and compared. Statistical correlations between pH, CO2, and various SIM variables were performed, as well as between the sum of effects (SOE) of the SIM and the individual variables comprising the SOE. Results The HH model identified acid‐base disorders in 31/44 cases of which 16/31 were mixed with metabolic acidosis and concurrent respiratory alkalosis the most common (10/31). Using the FS approach, metabolic changes were present 36/42 cases, with changes in free water (FW), chloride, and unmeasured anions (UA) being the most prevalent. Both FW and UA correlated well with pH; however, UA were most consistently abnormal in severe acidemia. Similarly to the HH, the VDM detected acid‐base disturbances in 28/44 cases. Major contributors to the acid‐base changes were hyponatremia, hypochloremia, and Atot acidosis because of elevated globulins and increased UA. Conclusions and Clinical Importance Acid‐base changes are common and complex in dogs with PE, and were easier to understand using a SIM paradigm. Increases in UA have not been documented in PE in dogs. |
| first_indexed | 2024-12-13T00:30:54Z |
| format | Article |
| id | doaj.art-67dc21aeff864755a28ac9d69d09ce4d |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-12-13T00:30:54Z |
| publishDate | 2020-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-67dc21aeff864755a28ac9d69d09ce4d2022-12-22T00:05:19ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762020-03-0134285786610.1111/jvim.15749Role of electrolyte abnormalities and unmeasured anions in the metabolic acid‐base abnormalities in dogs with parvoviral enteritisRichard K. Burchell0Arnon Gal1Ryan Friedlein2Andrew L. Leisewitz3Veterinary and Biomedical Sciences James Cook University Townsville Queensland AustraliaDepartment of Veterinary Clinical Medicine College of Veterinary Medicine, University of Illinois at Urbana‐Champaign Urbana Illinois USADepartment of Companion Animal Clinical Studies, Faculty of Veterinary Science University of Pretoria Pretoria South AfricaDepartment of Companion Animal Clinical Studies, Faculty of Veterinary Science University of Pretoria Pretoria South AfricaAbstract Background The strong ion model (SIM) is an alternative paradigm in the characterization of acid‐base disturbances particularly in complex disorders. Hypothesis/Objectives To compare the acid‐base changes in dogs with parvoviral enteritis (PE) using the Henderson‐Hasselbalch (HH) approach, with 2 strong ion approaches. Animals Forty‐four dogs with PE, and 16 age‐matched control dogs. Methods Prospective controlled observational study. Acid‐base status was evaluated using the HH model, Fencl‐Stewart (FS) approach and a validated strong ion model (VDM). The acid‐base changes according to each model were classified and compared. Statistical correlations between pH, CO2, and various SIM variables were performed, as well as between the sum of effects (SOE) of the SIM and the individual variables comprising the SOE. Results The HH model identified acid‐base disorders in 31/44 cases of which 16/31 were mixed with metabolic acidosis and concurrent respiratory alkalosis the most common (10/31). Using the FS approach, metabolic changes were present 36/42 cases, with changes in free water (FW), chloride, and unmeasured anions (UA) being the most prevalent. Both FW and UA correlated well with pH; however, UA were most consistently abnormal in severe acidemia. Similarly to the HH, the VDM detected acid‐base disturbances in 28/44 cases. Major contributors to the acid‐base changes were hyponatremia, hypochloremia, and Atot acidosis because of elevated globulins and increased UA. Conclusions and Clinical Importance Acid‐base changes are common and complex in dogs with PE, and were easier to understand using a SIM paradigm. Increases in UA have not been documented in PE in dogs.https://doi.org/10.1111/jvim.15749acid‐basecanine parvovirusHenderson‐Hasselbalchstrong ion model |
| spellingShingle | Richard K. Burchell Arnon Gal Ryan Friedlein Andrew L. Leisewitz Role of electrolyte abnormalities and unmeasured anions in the metabolic acid‐base abnormalities in dogs with parvoviral enteritis Journal of Veterinary Internal Medicine acid‐base canine parvovirus Henderson‐Hasselbalch strong ion model |
| title | Role of electrolyte abnormalities and unmeasured anions in the metabolic acid‐base abnormalities in dogs with parvoviral enteritis |
| title_full | Role of electrolyte abnormalities and unmeasured anions in the metabolic acid‐base abnormalities in dogs with parvoviral enteritis |
| title_fullStr | Role of electrolyte abnormalities and unmeasured anions in the metabolic acid‐base abnormalities in dogs with parvoviral enteritis |
| title_full_unstemmed | Role of electrolyte abnormalities and unmeasured anions in the metabolic acid‐base abnormalities in dogs with parvoviral enteritis |
| title_short | Role of electrolyte abnormalities and unmeasured anions in the metabolic acid‐base abnormalities in dogs with parvoviral enteritis |
| title_sort | role of electrolyte abnormalities and unmeasured anions in the metabolic acid base abnormalities in dogs with parvoviral enteritis |
| topic | acid‐base canine parvovirus Henderson‐Hasselbalch strong ion model |
| url | https://doi.org/10.1111/jvim.15749 |
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