Exposure to environmentally relevant concentrations of ambient fine particulate matter (PM2.5) depletes the ovarian follicle reserve and causes sex-dependent cardiovascular changes in apolipoprotein E null mice

Exposure to environmentally relevant concentrations of ambient fine particulate matter (PM2.5) depletes the ovarian follicle reserve and causes sex-dependent cardiovascular changes in apolipoprotein E null mice

Abstract Background Fine particulate matter (PM2.5) exposure accelerates atherosclerosis and contains known ovotoxic chemicals. However, effects of exposure to PM2.5 on the finite ovarian follicle pool have hardly been investigated, nor have interactions between ovarian and cardiovascular effects. W...

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Bibliographic Details
Main Authors: Ulrike Luderer, Jinhwan Lim, Laura Ortiz, Johnny D. Nguyen, Joyce H. Shin, Barrett D. Allen, Lisa S. Liao, Kelli Malott, Veronique Perraud, Lisa M. Wingen, Rebecca J. Arechavala, Bishop Bliss, David A. Herman, Michael T. Kleinman
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Particle and Fibre Toxicology
Subjects:
PM2.5
Ovary
Ovarian follicle
Atherosclerosis
Blood pressure
Heart rate variability
Online Access:https://doi.org/10.1186/s12989-021-00445-8

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