Molecular Characteristics in MRI-classified Group 1 Glioblastoma Multiforme
Glioblastoma multiforme (GBM) is a clinically and pathologically heterogeneous brain tumor. Previous study of MRI-classified GBM has revealed a spatial relationship between Group 1 GBM (GBM1) and the subventricular zone (SVZ). The SVZ is an adult neural stem cell niche and is also suspected to be t...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-07-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00182/full |
| _version_ | 1819127412371226624 |
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| author | William E Haskins Bethany L Zablotsky Michael R Foret Rebecca A Ihrie Arturo eAlvarez-Buylla Robert N Eisenman Mitchel S Berger Chin-Hsing Annie Lin |
| author_facet | William E Haskins Bethany L Zablotsky Michael R Foret Rebecca A Ihrie Arturo eAlvarez-Buylla Robert N Eisenman Mitchel S Berger Chin-Hsing Annie Lin |
| author_sort | William E Haskins |
| collection | DOAJ |
| description | Glioblastoma multiforme (GBM) is a clinically and pathologically heterogeneous brain tumor. Previous study of MRI-classified GBM has revealed a spatial relationship between Group 1 GBM (GBM1) and the subventricular zone (SVZ). The SVZ is an adult neural stem cell niche and is also suspected to be the origin of a subtype of brain tumor. The intimate contact between GBM1 and the SVZ raises the possibility that tumor cells in GBM1 may be most related to SVZ cells. In support of this notion, we found that neural stem cell and neuroblast markers are highly expressed in GBM1. Additionally, we identified molecular characteristics in this type of GBM that include up-regulation of metabolic enzymes, ribosomal proteins, heat shock proteins, and c-Myc oncoprotein. As GBM1 often recurs at great distances from the initial lesion, the rewiring of metabolism and ribosomal biogenesis may facilitate cancer cells’ growth and survival during tumor migration. Taken together, combined our findings and MRI-based classification of GBM1 would offer better prediction and treatment for this multifocal GBM. |
| first_indexed | 2024-12-22T08:11:31Z |
| format | Article |
| id | doaj.art-67e16c3ab848468c8fce5d108f2cf60f |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-22T08:11:31Z |
| publishDate | 2013-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-67e16c3ab848468c8fce5d108f2cf60f2022-12-21T18:33:01ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2013-07-01310.3389/fonc.2013.0018254322Molecular Characteristics in MRI-classified Group 1 Glioblastoma MultiformeWilliam E Haskins0Bethany L Zablotsky1Michael R Foret2Rebecca A Ihrie3Arturo eAlvarez-Buylla4Robert N Eisenman5Mitchel S Berger6Chin-Hsing Annie Lin7University of Texas at San AntonioUniversity of Texas at San AntonioUniversity of Texas at San AntonioVanderbilt University Medical CenterUniversity of California at San FranciscoFred Hutchinson Cancer Research CenterUniversity of California at San FranciscoUniversity of Texas at San AntonioGlioblastoma multiforme (GBM) is a clinically and pathologically heterogeneous brain tumor. Previous study of MRI-classified GBM has revealed a spatial relationship between Group 1 GBM (GBM1) and the subventricular zone (SVZ). The SVZ is an adult neural stem cell niche and is also suspected to be the origin of a subtype of brain tumor. The intimate contact between GBM1 and the SVZ raises the possibility that tumor cells in GBM1 may be most related to SVZ cells. In support of this notion, we found that neural stem cell and neuroblast markers are highly expressed in GBM1. Additionally, we identified molecular characteristics in this type of GBM that include up-regulation of metabolic enzymes, ribosomal proteins, heat shock proteins, and c-Myc oncoprotein. As GBM1 often recurs at great distances from the initial lesion, the rewiring of metabolism and ribosomal biogenesis may facilitate cancer cells’ growth and survival during tumor migration. Taken together, combined our findings and MRI-based classification of GBM1 would offer better prediction and treatment for this multifocal GBM.http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00182/fullHeat shock proteinGBMoncoproteinSVZRIBOGENESIS |
| spellingShingle | William E Haskins Bethany L Zablotsky Michael R Foret Rebecca A Ihrie Arturo eAlvarez-Buylla Robert N Eisenman Mitchel S Berger Chin-Hsing Annie Lin Molecular Characteristics in MRI-classified Group 1 Glioblastoma Multiforme Frontiers in Oncology Heat shock protein GBM oncoprotein SVZ RIBOGENESIS |
| title | Molecular Characteristics in MRI-classified Group 1 Glioblastoma Multiforme |
| title_full | Molecular Characteristics in MRI-classified Group 1 Glioblastoma Multiforme |
| title_fullStr | Molecular Characteristics in MRI-classified Group 1 Glioblastoma Multiforme |
| title_full_unstemmed | Molecular Characteristics in MRI-classified Group 1 Glioblastoma Multiforme |
| title_short | Molecular Characteristics in MRI-classified Group 1 Glioblastoma Multiforme |
| title_sort | molecular characteristics in mri classified group 1 glioblastoma multiforme |
| topic | Heat shock protein GBM oncoprotein SVZ RIBOGENESIS |
| url | http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00182/full |
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