Body Weight Determination and Histological Examination of Livers in Normal Rats Administered with Tamsulosin
The objective of this study was to investigate histopathology of livers and carry out body weight determination in normal rats administered with tamsulosin. Standard methods and procedures were used in this study. The results were revealed. Pertaining weight, at the 3rd , 6th and 8th weeks of the...
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| Format: | Article |
| Language: | English |
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Joint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP)
2020-09-01
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| Series: | Journal of Applied Sciences and Environmental Management |
| Subjects: | |
| Online Access: | https://www.ajol.info/index.php/jasem/article/view/199543 |
| _version_ | 1827297191912275968 |
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| author | M. Dikko Y. Sarkingobir |
| author_facet | M. Dikko Y. Sarkingobir |
| author_sort | M. Dikko |
| collection | DOAJ |
| description |
The objective of this study was to investigate histopathology of livers and carry out body weight determination in normal rats administered with tamsulosin. Standard methods and procedures were used in this study. The results were revealed. Pertaining weight, at the 3rd , 6th and 8th weeks of the study, no significant difference (P>0.05) in weight was found in the group of rats treated with carvedilol (positive control), tamsulosin low dose (12μg/kg) and high dose tamsulosin (40μg/kg) compared to normal control group, respectively. Other inter-groups comparisons were not significantly different, respectively. Pertaining liver morphology, liver sections of groups revealed no significant histological lesions compared to the normal control group at the 6th and 8th weeks of the study, respectively. This study revealed that the tamsulosin cause no histopathological lesion, thus the drug might be safe to the liver and its biochemical processes.
Keywords: Tamsulosin, Liver, histopathology, weight, Wistar rats
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| first_indexed | 2024-04-24T14:51:17Z |
| format | Article |
| id | doaj.art-67e1c354f9414328af510051c39f7f9e |
| institution | Directory Open Access Journal |
| issn | 2659-1502 2659-1499 |
| language | English |
| last_indexed | 2024-04-24T14:51:17Z |
| publishDate | 2020-09-01 |
| publisher | Joint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP) |
| record_format | Article |
| series | Journal of Applied Sciences and Environmental Management |
| spelling | doaj.art-67e1c354f9414328af510051c39f7f9e2024-04-02T19:49:04ZengJoint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP)Journal of Applied Sciences and Environmental Management2659-15022659-14992020-09-0124810.4314/jasem.v24i8.5Body Weight Determination and Histological Examination of Livers in Normal Rats Administered with TamsulosinM. DikkoY. Sarkingobir The objective of this study was to investigate histopathology of livers and carry out body weight determination in normal rats administered with tamsulosin. Standard methods and procedures were used in this study. The results were revealed. Pertaining weight, at the 3rd , 6th and 8th weeks of the study, no significant difference (P>0.05) in weight was found in the group of rats treated with carvedilol (positive control), tamsulosin low dose (12μg/kg) and high dose tamsulosin (40μg/kg) compared to normal control group, respectively. Other inter-groups comparisons were not significantly different, respectively. Pertaining liver morphology, liver sections of groups revealed no significant histological lesions compared to the normal control group at the 6th and 8th weeks of the study, respectively. This study revealed that the tamsulosin cause no histopathological lesion, thus the drug might be safe to the liver and its biochemical processes. Keywords: Tamsulosin, Liver, histopathology, weight, Wistar rats https://www.ajol.info/index.php/jasem/article/view/199543Tamsulosin, Liver, histopathology, weight, Wistar rats |
| spellingShingle | M. Dikko Y. Sarkingobir Body Weight Determination and Histological Examination of Livers in Normal Rats Administered with Tamsulosin Journal of Applied Sciences and Environmental Management Tamsulosin, Liver, histopathology, weight, Wistar rats |
| title | Body Weight Determination and Histological Examination of Livers in Normal Rats Administered with Tamsulosin |
| title_full | Body Weight Determination and Histological Examination of Livers in Normal Rats Administered with Tamsulosin |
| title_fullStr | Body Weight Determination and Histological Examination of Livers in Normal Rats Administered with Tamsulosin |
| title_full_unstemmed | Body Weight Determination and Histological Examination of Livers in Normal Rats Administered with Tamsulosin |
| title_short | Body Weight Determination and Histological Examination of Livers in Normal Rats Administered with Tamsulosin |
| title_sort | body weight determination and histological examination of livers in normal rats administered with tamsulosin |
| topic | Tamsulosin, Liver, histopathology, weight, Wistar rats |
| url | https://www.ajol.info/index.php/jasem/article/view/199543 |
| work_keys_str_mv | AT mdikko bodyweightdeterminationandhistologicalexaminationofliversinnormalratsadministeredwithtamsulosin AT ysarkingobir bodyweightdeterminationandhistologicalexaminationofliversinnormalratsadministeredwithtamsulosin |