Structure–immunomodulatory activity relationships of dietary polysaccharides
Polysaccharides are usually composed of more than ten monosaccharide units, which are connected by linear or branched glycosidic bonds. The immunomodulatory effect of natural polysaccharides is one of the most important bioactive function. In this review, molecular weight, monosaccharide (including...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Current Research in Food Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665927122001332 |
| _version_ | 1811178864576036864 |
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| author | Ruoxin Chen Jingxiang Xu Weihao Wu Yuxi Wen Suyue Lu Hesham R. El-Seedi Chao Zhao |
| author_facet | Ruoxin Chen Jingxiang Xu Weihao Wu Yuxi Wen Suyue Lu Hesham R. El-Seedi Chao Zhao |
| author_sort | Ruoxin Chen |
| collection | DOAJ |
| description | Polysaccharides are usually composed of more than ten monosaccharide units, which are connected by linear or branched glycosidic bonds. The immunomodulatory effect of natural polysaccharides is one of the most important bioactive function. In this review, molecular weight, monosaccharide (including galactose, mannose, rhamnogalacturonan-I arabinogalactan and uronic acid), functional groups (namely sulfate, selenium, and acetyl groups), types of glycoside bond connection (including β-1,3-D-glucosyl, α-1,4-D-glucosyl, β-1,4-D-glucosyl, α-1,6-D-glucosyl, β-1,4-D-mannosyl, and β-1,4-D-Xylopyranosyl), conformation and the branching degrees are systematically identified as their contribution to the immunostimulatory activity of polysaccharides. At present, studies on the structure-activity relationships of polysaccharides are limited due to their low purity and high heterogeneity. However, it is an important step in providing useful guidance for dietary supplements with polysaccharides. The chemical structures and the process of immune responses induced are necessary to be discussed. Polysaccharides may bind with the cell surface receptors to modulate immune responses. This review mainly discusses the structure-activity relationship of dietary polysaccharides. |
| first_indexed | 2024-04-11T06:25:08Z |
| format | Article |
| id | doaj.art-67e265bde17e4cf5b28c75738097b867 |
| institution | Directory Open Access Journal |
| issn | 2665-9271 |
| language | English |
| last_indexed | 2024-04-11T06:25:08Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Food Science |
| spelling | doaj.art-67e265bde17e4cf5b28c75738097b8672022-12-22T04:40:23ZengElsevierCurrent Research in Food Science2665-92712022-01-01513301341Structure–immunomodulatory activity relationships of dietary polysaccharidesRuoxin Chen0Jingxiang Xu1Weihao Wu2Yuxi Wen3Suyue Lu4Hesham R. El-Seedi5Chao Zhao6College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, ChinaSchool of Basic Medicine, Gannan Medical University, Ganzhou, 341000, ChinaCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, ChinaCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, ChinaCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, ChinaPharmacognosy Group, Department of Pharmaceutical Biosciences, Uppsala University, Biomedical Centre, Box 574, 751 23, Uppsala, Sweden; International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang, 212013, China; International Joint Research Laboratory of Intelligent Agriculture and Agri-Products Processing, Jiangsu Education Department, Jiangsu University, Zhenjiang, ChinaCollege of Marine Sciences, Fujian Agriculture and Forestry University, Fuzhou, 350002, China; College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China; Key Laboratory of Marine Biotechnology of Fujian Province, Institute of Oceanology, Fujian Agriculture and Forestry University, Fuzhou, 350002, China; Corresponding author.No.15 Shangxiadian Rd, Fuzhou, 350002, ChinaPolysaccharides are usually composed of more than ten monosaccharide units, which are connected by linear or branched glycosidic bonds. The immunomodulatory effect of natural polysaccharides is one of the most important bioactive function. In this review, molecular weight, monosaccharide (including galactose, mannose, rhamnogalacturonan-I arabinogalactan and uronic acid), functional groups (namely sulfate, selenium, and acetyl groups), types of glycoside bond connection (including β-1,3-D-glucosyl, α-1,4-D-glucosyl, β-1,4-D-glucosyl, α-1,6-D-glucosyl, β-1,4-D-mannosyl, and β-1,4-D-Xylopyranosyl), conformation and the branching degrees are systematically identified as their contribution to the immunostimulatory activity of polysaccharides. At present, studies on the structure-activity relationships of polysaccharides are limited due to their low purity and high heterogeneity. However, it is an important step in providing useful guidance for dietary supplements with polysaccharides. The chemical structures and the process of immune responses induced are necessary to be discussed. Polysaccharides may bind with the cell surface receptors to modulate immune responses. This review mainly discusses the structure-activity relationship of dietary polysaccharides.http://www.sciencedirect.com/science/article/pii/S2665927122001332PolysaccharideImmune-enhancing activityStructure-activity relationships |
| spellingShingle | Ruoxin Chen Jingxiang Xu Weihao Wu Yuxi Wen Suyue Lu Hesham R. El-Seedi Chao Zhao Structure–immunomodulatory activity relationships of dietary polysaccharides Current Research in Food Science Polysaccharide Immune-enhancing activity Structure-activity relationships |
| title | Structure–immunomodulatory activity relationships of dietary polysaccharides |
| title_full | Structure–immunomodulatory activity relationships of dietary polysaccharides |
| title_fullStr | Structure–immunomodulatory activity relationships of dietary polysaccharides |
| title_full_unstemmed | Structure–immunomodulatory activity relationships of dietary polysaccharides |
| title_short | Structure–immunomodulatory activity relationships of dietary polysaccharides |
| title_sort | structure immunomodulatory activity relationships of dietary polysaccharides |
| topic | Polysaccharide Immune-enhancing activity Structure-activity relationships |
| url | http://www.sciencedirect.com/science/article/pii/S2665927122001332 |
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