Topical Treatment for the Management of Mild-to-Moderate Psoriasis: A Critical Appraisal of the Current Literature
Abstract Several comprehensive and updated guidelines are available on the management of psoriasis with systemic treatments. However, there is a lack of updates in recommendations and guidelines on topical treatments, particularly regarding the latest evidence and developments in treatment formulati...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2023-09-01
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| Series: | Dermatology and Therapy |
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| Online Access: | https://doi.org/10.1007/s13555-023-01024-9 |
| _version_ | 1797647401468559360 |
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| author | Maria Concetta Fargnoli Clara De Simone Paolo Gisondi Giovanni Pellacani Piergiacomo Calzavara-Pinton |
| author_facet | Maria Concetta Fargnoli Clara De Simone Paolo Gisondi Giovanni Pellacani Piergiacomo Calzavara-Pinton |
| author_sort | Maria Concetta Fargnoli |
| collection | DOAJ |
| description | Abstract Several comprehensive and updated guidelines are available on the management of psoriasis with systemic treatments. However, there is a lack of updates in recommendations and guidelines on topical treatments, particularly regarding the latest evidence and developments in treatment formulations. Consequently, a comprehensive literature review on this topic, considering the continuous evolution of knowledge and evaluation of the relevance of the available literature evidence, represents a current need to improve the topical management of psoriasis. This study critically appraises the available literature on all topical treatments of psoriasis from the past 20 years to address some relevant issues, such as the vehicle associated with the highest effectiveness, the best vehicle for improving patient adherence, and the best strategy in terms of efficacy and safety for long-term treatment. The greater effectiveness of the foam formulation was demonstrated for calcipotriene/betamethasone dipropionate (Cal/BD) administration compared with the gel and ointment. Without a direct comparison, matching-adjusted indirect comparison analyses support the superiority of the foam versus the cream overall. In addition, the reduced treatment period required by the Cal/BD foam (4 weeks) may favor this formulation over cream (8 weeks). The literature evidence, supported by a broad clinical experience, reported high rates of acceptability and adherence for the foam vehicle. A growing consensus is shared among dermatologists sustaining the proactive approach as the best option for the long-term topical treatment of psoriasis in adults. The Cal/BD foam is the only treatment for which the approved label allows biweekly maintenance use (proactive management), thus representing the first option for long-term topical treatment. |
| first_indexed | 2024-03-11T15:15:49Z |
| format | Article |
| id | doaj.art-67e3dc56bc114e5bb4771e9c0459f2ed |
| institution | Directory Open Access Journal |
| issn | 2193-8210 2190-9172 |
| language | English |
| last_indexed | 2024-03-11T15:15:49Z |
| publishDate | 2023-09-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Dermatology and Therapy |
| spelling | doaj.art-67e3dc56bc114e5bb4771e9c0459f2ed2023-10-29T12:15:01ZengAdis, Springer HealthcareDermatology and Therapy2193-82102190-91722023-09-0113112527254710.1007/s13555-023-01024-9Topical Treatment for the Management of Mild-to-Moderate Psoriasis: A Critical Appraisal of the Current LiteratureMaria Concetta Fargnoli0Clara De Simone1Paolo Gisondi2Giovanni Pellacani3Piergiacomo Calzavara-Pinton4Department of Biotechnological and Applied Clinical Sciences, University of L’AquilaSection of Dermatology, Department of Translational Medicine and Surgery, Catholic University of the S. HeartDepartment of Medicine, Section of Dermatology and Venereology, University of VeronaDepartment of Clinical Internal, Anesthesiologic and Cardiovascular Sciences, Dermatology Clinic, Sapienza Medical School, Sapienza University of RomeDermatology Unit, Department of Clinical and Experimental Sciences, University of BresciaAbstract Several comprehensive and updated guidelines are available on the management of psoriasis with systemic treatments. However, there is a lack of updates in recommendations and guidelines on topical treatments, particularly regarding the latest evidence and developments in treatment formulations. Consequently, a comprehensive literature review on this topic, considering the continuous evolution of knowledge and evaluation of the relevance of the available literature evidence, represents a current need to improve the topical management of psoriasis. This study critically appraises the available literature on all topical treatments of psoriasis from the past 20 years to address some relevant issues, such as the vehicle associated with the highest effectiveness, the best vehicle for improving patient adherence, and the best strategy in terms of efficacy and safety for long-term treatment. The greater effectiveness of the foam formulation was demonstrated for calcipotriene/betamethasone dipropionate (Cal/BD) administration compared with the gel and ointment. Without a direct comparison, matching-adjusted indirect comparison analyses support the superiority of the foam versus the cream overall. In addition, the reduced treatment period required by the Cal/BD foam (4 weeks) may favor this formulation over cream (8 weeks). The literature evidence, supported by a broad clinical experience, reported high rates of acceptability and adherence for the foam vehicle. A growing consensus is shared among dermatologists sustaining the proactive approach as the best option for the long-term topical treatment of psoriasis in adults. The Cal/BD foam is the only treatment for which the approved label allows biweekly maintenance use (proactive management), thus representing the first option for long-term topical treatment.https://doi.org/10.1007/s13555-023-01024-9PsoriasisTopical treatmentBetamethasone dipropionateCalcipotrieneVehicleAdherence |
| spellingShingle | Maria Concetta Fargnoli Clara De Simone Paolo Gisondi Giovanni Pellacani Piergiacomo Calzavara-Pinton Topical Treatment for the Management of Mild-to-Moderate Psoriasis: A Critical Appraisal of the Current Literature Dermatology and Therapy Psoriasis Topical treatment Betamethasone dipropionate Calcipotriene Vehicle Adherence |
| title | Topical Treatment for the Management of Mild-to-Moderate Psoriasis: A Critical Appraisal of the Current Literature |
| title_full | Topical Treatment for the Management of Mild-to-Moderate Psoriasis: A Critical Appraisal of the Current Literature |
| title_fullStr | Topical Treatment for the Management of Mild-to-Moderate Psoriasis: A Critical Appraisal of the Current Literature |
| title_full_unstemmed | Topical Treatment for the Management of Mild-to-Moderate Psoriasis: A Critical Appraisal of the Current Literature |
| title_short | Topical Treatment for the Management of Mild-to-Moderate Psoriasis: A Critical Appraisal of the Current Literature |
| title_sort | topical treatment for the management of mild to moderate psoriasis a critical appraisal of the current literature |
| topic | Psoriasis Topical treatment Betamethasone dipropionate Calcipotriene Vehicle Adherence |
| url | https://doi.org/10.1007/s13555-023-01024-9 |
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