High genetic diversity and adaptive potential of two simian hemorrhagic fever viruses in a wild primate population.
Key biological properties such as high genetic diversity and high evolutionary rate enhance the potential of certain RNA viruses to adapt and emerge. Identifying viruses with these properties in their natural hosts could dramatically improve disease forecasting and surveillance. Recently, we discove...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3961216?pdf=render |
| _version_ | 1818948193637892096 |
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| author | Adam L Bailey Michael Lauck Andrea Weiler Samuel D Sibley Jorge M Dinis Zachary Bergman Chase W Nelson Michael Correll Michael Gleicher David Hyeroba Alex Tumukunde Geoffrey Weny Colin Chapman Jens H Kuhn Austin L Hughes Thomas C Friedrich Tony L Goldberg David H O'Connor |
| author_facet | Adam L Bailey Michael Lauck Andrea Weiler Samuel D Sibley Jorge M Dinis Zachary Bergman Chase W Nelson Michael Correll Michael Gleicher David Hyeroba Alex Tumukunde Geoffrey Weny Colin Chapman Jens H Kuhn Austin L Hughes Thomas C Friedrich Tony L Goldberg David H O'Connor |
| author_sort | Adam L Bailey |
| collection | DOAJ |
| description | Key biological properties such as high genetic diversity and high evolutionary rate enhance the potential of certain RNA viruses to adapt and emerge. Identifying viruses with these properties in their natural hosts could dramatically improve disease forecasting and surveillance. Recently, we discovered two novel members of the viral family Arteriviridae: simian hemorrhagic fever virus (SHFV)-krc1 and SHFV-krc2, infecting a single wild red colobus (Procolobus rufomitratus tephrosceles) in Kibale National Park, Uganda. Nearly nothing is known about the biological properties of SHFVs in nature, although the SHFV type strain, SHFV-LVR, has caused devastating outbreaks of viral hemorrhagic fever in captive macaques. Here we detected SHFV-krc1 and SHFV-krc2 in 40% and 47% of 60 wild red colobus tested, respectively. We found viral loads in excess of 10(6)-10(7) RNA copies per milliliter of blood plasma for each of these viruses. SHFV-krc1 and SHFV-krc2 also showed high genetic diversity at both the inter- and intra-host levels. Analyses of synonymous and non-synonymous nucleotide diversity across viral genomes revealed patterns suggestive of positive selection in SHFV open reading frames (ORF) 5 (SHFV-krc2 only) and 7 (SHFV-krc1 and SHFV-krc2). Thus, these viruses share several important properties with some of the most rapidly evolving, emergent RNA viruses. |
| first_indexed | 2024-12-20T08:42:55Z |
| format | Article |
| id | doaj.art-67e4f25caf974afdaea4874a763ebde1 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T08:42:55Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-67e4f25caf974afdaea4874a763ebde12022-12-21T19:46:20ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0193e9071410.1371/journal.pone.0090714High genetic diversity and adaptive potential of two simian hemorrhagic fever viruses in a wild primate population.Adam L BaileyMichael LauckAndrea WeilerSamuel D SibleyJorge M DinisZachary BergmanChase W NelsonMichael CorrellMichael GleicherDavid HyerobaAlex TumukundeGeoffrey WenyColin ChapmanJens H KuhnAustin L HughesThomas C FriedrichTony L GoldbergDavid H O'ConnorKey biological properties such as high genetic diversity and high evolutionary rate enhance the potential of certain RNA viruses to adapt and emerge. Identifying viruses with these properties in their natural hosts could dramatically improve disease forecasting and surveillance. Recently, we discovered two novel members of the viral family Arteriviridae: simian hemorrhagic fever virus (SHFV)-krc1 and SHFV-krc2, infecting a single wild red colobus (Procolobus rufomitratus tephrosceles) in Kibale National Park, Uganda. Nearly nothing is known about the biological properties of SHFVs in nature, although the SHFV type strain, SHFV-LVR, has caused devastating outbreaks of viral hemorrhagic fever in captive macaques. Here we detected SHFV-krc1 and SHFV-krc2 in 40% and 47% of 60 wild red colobus tested, respectively. We found viral loads in excess of 10(6)-10(7) RNA copies per milliliter of blood plasma for each of these viruses. SHFV-krc1 and SHFV-krc2 also showed high genetic diversity at both the inter- and intra-host levels. Analyses of synonymous and non-synonymous nucleotide diversity across viral genomes revealed patterns suggestive of positive selection in SHFV open reading frames (ORF) 5 (SHFV-krc2 only) and 7 (SHFV-krc1 and SHFV-krc2). Thus, these viruses share several important properties with some of the most rapidly evolving, emergent RNA viruses.http://europepmc.org/articles/PMC3961216?pdf=render |
| spellingShingle | Adam L Bailey Michael Lauck Andrea Weiler Samuel D Sibley Jorge M Dinis Zachary Bergman Chase W Nelson Michael Correll Michael Gleicher David Hyeroba Alex Tumukunde Geoffrey Weny Colin Chapman Jens H Kuhn Austin L Hughes Thomas C Friedrich Tony L Goldberg David H O'Connor High genetic diversity and adaptive potential of two simian hemorrhagic fever viruses in a wild primate population. PLoS ONE |
| title | High genetic diversity and adaptive potential of two simian hemorrhagic fever viruses in a wild primate population. |
| title_full | High genetic diversity and adaptive potential of two simian hemorrhagic fever viruses in a wild primate population. |
| title_fullStr | High genetic diversity and adaptive potential of two simian hemorrhagic fever viruses in a wild primate population. |
| title_full_unstemmed | High genetic diversity and adaptive potential of two simian hemorrhagic fever viruses in a wild primate population. |
| title_short | High genetic diversity and adaptive potential of two simian hemorrhagic fever viruses in a wild primate population. |
| title_sort | high genetic diversity and adaptive potential of two simian hemorrhagic fever viruses in a wild primate population |
| url | http://europepmc.org/articles/PMC3961216?pdf=render |
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