Novel roles of karyopherin subunit alpha 2 in hepatocellular carcinoma
Hepatocellular carcinoma is the most common type of liver cancer and associated with a high fatality rate. This disease poses a major threat to human health worldwide. A considerable number of genetic and epigenetic factors are involved in the development of hepatocellular carcinoma. However, the mo...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | Biomedicine & Pharmacotherapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223005814 |
| _version_ | 1797822116316315648 |
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| author | Xingyue Yang Hu Wang Li Zhang Shun Yao Jing Dai Guorong Wen Jiaxing An Hai Jin Qian Du Yanxia Hu Liming Zheng Xingyue Chen Zhiqiang Yi Biguang Tuo |
| author_facet | Xingyue Yang Hu Wang Li Zhang Shun Yao Jing Dai Guorong Wen Jiaxing An Hai Jin Qian Du Yanxia Hu Liming Zheng Xingyue Chen Zhiqiang Yi Biguang Tuo |
| author_sort | Xingyue Yang |
| collection | DOAJ |
| description | Hepatocellular carcinoma is the most common type of liver cancer and associated with a high fatality rate. This disease poses a major threat to human health worldwide. A considerable number of genetic and epigenetic factors are involved in the development of hepatocellular carcinoma. However, the molecular mechanism underlying the progression of hepatocellular carcinoma remains unclear. Karyopherin subunit alpha 2 (KPNA2), also termed importin α1, is a member of the nuclear transporter family. In recent years, KPNA2 has been gradually linked to the nuclear transport pathway for a variety of tumor-associated proteins. Furthermore, it promotes tumor development by participating in various pathophysiological processes such as cell proliferation, apoptosis, immune response, and viral infection. In hepatocellular carcinoma, it has been found that KPNA2 expression is significantly higher in liver cancer tissues versus paracancerous tissues. Moreover, it has been identified as a marker of poor prognosis and early recurrence in patients with hepatocellular carcinoma. Nevertheless, the role of KPNA2 in the development of hepatocellular carcinoma remains to be determined. This review summarizes the current knowledge on the pathogenesis and role of KPNA2 in hepatocellular carcinoma, and provides new directions and strategies for the diagnosis, treatment, and prediction of prognosis of this disease. |
| first_indexed | 2024-03-13T10:03:08Z |
| format | Article |
| id | doaj.art-67e7b35776ca485b92cf8c048b0abe26 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-13T10:03:08Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-67e7b35776ca485b92cf8c048b0abe262023-05-23T04:21:05ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-07-01163114792Novel roles of karyopherin subunit alpha 2 in hepatocellular carcinomaXingyue Yang0Hu Wang1Li Zhang2Shun Yao3Jing Dai4Guorong Wen5Jiaxing An6Hai Jin7Qian Du8Yanxia Hu9Liming Zheng10Xingyue Chen11Zhiqiang Yi12Biguang Tuo13Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of General Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, China; The Collaborative Innovation Center of Tissue Damage Repair and Regenerative Medicine of Zunyi Medical University, Zunyi, China; Corresponding author at: Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, China.Hepatocellular carcinoma is the most common type of liver cancer and associated with a high fatality rate. This disease poses a major threat to human health worldwide. A considerable number of genetic and epigenetic factors are involved in the development of hepatocellular carcinoma. However, the molecular mechanism underlying the progression of hepatocellular carcinoma remains unclear. Karyopherin subunit alpha 2 (KPNA2), also termed importin α1, is a member of the nuclear transporter family. In recent years, KPNA2 has been gradually linked to the nuclear transport pathway for a variety of tumor-associated proteins. Furthermore, it promotes tumor development by participating in various pathophysiological processes such as cell proliferation, apoptosis, immune response, and viral infection. In hepatocellular carcinoma, it has been found that KPNA2 expression is significantly higher in liver cancer tissues versus paracancerous tissues. Moreover, it has been identified as a marker of poor prognosis and early recurrence in patients with hepatocellular carcinoma. Nevertheless, the role of KPNA2 in the development of hepatocellular carcinoma remains to be determined. This review summarizes the current knowledge on the pathogenesis and role of KPNA2 in hepatocellular carcinoma, and provides new directions and strategies for the diagnosis, treatment, and prediction of prognosis of this disease.http://www.sciencedirect.com/science/article/pii/S0753332223005814Karyopherin subunit alpha 2P53AKT signaling pathwaysMiRNAs |
| spellingShingle | Xingyue Yang Hu Wang Li Zhang Shun Yao Jing Dai Guorong Wen Jiaxing An Hai Jin Qian Du Yanxia Hu Liming Zheng Xingyue Chen Zhiqiang Yi Biguang Tuo Novel roles of karyopherin subunit alpha 2 in hepatocellular carcinoma Biomedicine & Pharmacotherapy Karyopherin subunit alpha 2 P53 AKT signaling pathways MiRNAs |
| title | Novel roles of karyopherin subunit alpha 2 in hepatocellular carcinoma |
| title_full | Novel roles of karyopherin subunit alpha 2 in hepatocellular carcinoma |
| title_fullStr | Novel roles of karyopherin subunit alpha 2 in hepatocellular carcinoma |
| title_full_unstemmed | Novel roles of karyopherin subunit alpha 2 in hepatocellular carcinoma |
| title_short | Novel roles of karyopherin subunit alpha 2 in hepatocellular carcinoma |
| title_sort | novel roles of karyopherin subunit alpha 2 in hepatocellular carcinoma |
| topic | Karyopherin subunit alpha 2 P53 AKT signaling pathways MiRNAs |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223005814 |
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