Plasma Exosomal Proteomic Pattern of Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis
Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a life-threatening syndrome, which is caused by EBV infection that is usually refractory to treatment and shows relapse. The development of new biomarkers for the early diagnosis and clinical treatment of EBV-HLH is...
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.821311/full |
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| author | Yan Xie Yan Xie Yan Xie Yan Xie Li Yang Li Yang Li Yang Li Yang Pengfei Cao Pengfei Cao Shen Li Shen Li Shen Li Shen Li Wentao Zhang Wentao Zhang Wentao Zhang Wentao Zhang Wei Dang Wei Dang Wei Dang Wei Dang Shuyu Xin Shuyu Xin Shuyu Xin Shuyu Xin Mingjuan Jiang Mingjuan Jiang Mingjuan Jiang Mingjuan Jiang Yujie Xin Yujie Xin Yujie Xin Yujie Xin Jing Li Jing Li Jing Li Jing Li Sijing Long Sijing Long Sijing Long Sijing Long Yiwei Wang Yiwei Wang Yiwei Wang Yiwei Wang Senmiao Zhang Senmiao Zhang Senmiao Zhang Senmiao Zhang Yang Yang Yang Yang Yang Yang Yang Yang Jianhong Lu Jianhong Lu Jianhong Lu Jianhong Lu |
| author_facet | Yan Xie Yan Xie Yan Xie Yan Xie Li Yang Li Yang Li Yang Li Yang Pengfei Cao Pengfei Cao Shen Li Shen Li Shen Li Shen Li Wentao Zhang Wentao Zhang Wentao Zhang Wentao Zhang Wei Dang Wei Dang Wei Dang Wei Dang Shuyu Xin Shuyu Xin Shuyu Xin Shuyu Xin Mingjuan Jiang Mingjuan Jiang Mingjuan Jiang Mingjuan Jiang Yujie Xin Yujie Xin Yujie Xin Yujie Xin Jing Li Jing Li Jing Li Jing Li Sijing Long Sijing Long Sijing Long Sijing Long Yiwei Wang Yiwei Wang Yiwei Wang Yiwei Wang Senmiao Zhang Senmiao Zhang Senmiao Zhang Senmiao Zhang Yang Yang Yang Yang Yang Yang Yang Yang Jianhong Lu Jianhong Lu Jianhong Lu Jianhong Lu |
| author_sort | Yan Xie |
| collection | DOAJ |
| description | Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a life-threatening syndrome, which is caused by EBV infection that is usually refractory to treatment and shows relapse. The development of new biomarkers for the early diagnosis and clinical treatment of EBV-HLH is urgently needed. Exosomes have been shown to mediate various biological processes and are ideal non-invasive biomarkers. Here, we present the differential plasma exosomal proteome of a patient with EBV-HLH before vs. during treatment and with that of his healthy twin brother. A tandem mass tag-labeled LC-MS technique was employed for proteomic detection. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses indicated that differential proteomic profiles were related to virus infection, coagulopathy, nervous system dysfunction, imbalance of immune response, and abnormal liver function. The candidate biomarkers were first identified in the patient’s plasma exosomes at different treatment and follow-up time points. Then, 14 additional EBV-HLH exosome samples were used to verify six differentially expressed proteins. The upregulation of C-reactive protein, moesin, galectin three-binding protein, and heat shock cognate 71 kDa protein and the downregulation of plasminogen and fibronectin 1 could serve as potential biomarkers of EBV-HLH. This plasma exosomal proteomic analysis provides new insights into the diagnostic and therapeutic biomarkers of EBV-HLH. |
| first_indexed | 2024-12-14T18:53:36Z |
| format | Article |
| id | doaj.art-67ead2bab4aa423bb530822e85fcf59a |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-14T18:53:36Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Microbiology |
| spelling | doaj.art-67ead2bab4aa423bb530822e85fcf59a2022-12-21T22:51:10ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-04-011310.3389/fmicb.2022.821311821311Plasma Exosomal Proteomic Pattern of Epstein-Barr Virus-Associated Hemophagocytic LymphohistiocytosisYan Xie0Yan Xie1Yan Xie2Yan Xie3Li Yang4Li Yang5Li Yang6Li Yang7Pengfei Cao8Pengfei Cao9Shen Li10Shen Li11Shen Li12Shen Li13Wentao Zhang14Wentao Zhang15Wentao Zhang16Wentao Zhang17Wei Dang18Wei Dang19Wei Dang20Wei Dang21Shuyu Xin22Shuyu Xin23Shuyu Xin24Shuyu Xin25Mingjuan Jiang26Mingjuan Jiang27Mingjuan Jiang28Mingjuan Jiang29Yujie Xin30Yujie Xin31Yujie Xin32Yujie Xin33Jing Li34Jing Li35Jing Li36Jing Li37Sijing Long38Sijing Long39Sijing Long40Sijing Long41Yiwei Wang42Yiwei Wang43Yiwei Wang44Yiwei Wang45Senmiao Zhang46Senmiao Zhang47Senmiao Zhang48Senmiao Zhang49Yang Yang50Yang Yang51Yang Yang52Yang Yang53Jianhong Lu54Jianhong Lu55Jianhong Lu56Jianhong Lu57Department of Hematology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Microbiology, School of Basic Medical Science, Central South University, Changsha, ChinaNational Healthcare Commission (NHC) Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, ChinaChina-Africa Research Center of Infectious Diseases, Central South University, Changsha, ChinaDepartment of Hematology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Microbiology, School of Basic Medical Science, Central South University, Changsha, ChinaNational Healthcare Commission (NHC) Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, ChinaChina-Africa Research Center of Infectious Diseases, Central South University, Changsha, ChinaDepartment of Hematology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaChina-Africa Research Center of Infectious Diseases, Central South University, Changsha, ChinaDepartment of Hematology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Microbiology, School of Basic Medical Science, Central South University, Changsha, ChinaNational Healthcare Commission (NHC) Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, ChinaChina-Africa Research Center of Infectious Diseases, Central South University, Changsha, ChinaDepartment of Hematology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Microbiology, School of Basic Medical Science, Central South University, Changsha, ChinaNational Healthcare Commission (NHC) Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, ChinaChina-Africa Research Center of Infectious Diseases, Central South University, Changsha, ChinaDepartment of Hematology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Microbiology, School of Basic Medical Science, Central South University, Changsha, ChinaNational Healthcare Commission (NHC) Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, ChinaChina-Africa Research Center of Infectious Diseases, Central South University, Changsha, ChinaDepartment of Hematology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Microbiology, School of Basic Medical Science, Central South University, Changsha, ChinaNational Healthcare Commission (NHC) Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, ChinaChina-Africa Research Center of Infectious Diseases, Central South University, Changsha, ChinaDepartment of Hematology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Microbiology, School of Basic Medical Science, Central South University, Changsha, ChinaNational Healthcare Commission (NHC) Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, ChinaChina-Africa Research Center of Infectious Diseases, Central South University, Changsha, ChinaDepartment of Hematology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Microbiology, School of Basic Medical Science, Central South University, Changsha, ChinaNational Healthcare Commission (NHC) Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, ChinaChina-Africa Research Center of Infectious Diseases, Central South University, Changsha, ChinaDepartment of Hematology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Microbiology, School of Basic Medical Science, Central South University, Changsha, ChinaNational Healthcare Commission (NHC) Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, ChinaChina-Africa Research Center of Infectious Diseases, Central South University, Changsha, ChinaDepartment of Hematology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Microbiology, School of Basic Medical Science, Central South University, Changsha, ChinaNational Healthcare Commission (NHC) Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, ChinaChina-Africa Research Center of Infectious Diseases, Central South University, Changsha, ChinaDepartment of Hematology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Microbiology, School of Basic Medical Science, Central South University, Changsha, ChinaNational Healthcare Commission (NHC) Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, ChinaChina-Africa Research Center of Infectious Diseases, Central South University, Changsha, ChinaDepartment of Hematology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Microbiology, School of Basic Medical Science, Central South University, Changsha, ChinaNational Healthcare Commission (NHC) Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, ChinaChina-Africa Research Center of Infectious Diseases, Central South University, Changsha, ChinaDepartment of Hematology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Microbiology, School of Basic Medical Science, Central South University, Changsha, ChinaNational Healthcare Commission (NHC) Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, ChinaChina-Africa Research Center of Infectious Diseases, Central South University, Changsha, ChinaDepartment of Hematology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Microbiology, School of Basic Medical Science, Central South University, Changsha, ChinaNational Healthcare Commission (NHC) Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, ChinaChina-Africa Research Center of Infectious Diseases, Central South University, Changsha, ChinaEpstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a life-threatening syndrome, which is caused by EBV infection that is usually refractory to treatment and shows relapse. The development of new biomarkers for the early diagnosis and clinical treatment of EBV-HLH is urgently needed. Exosomes have been shown to mediate various biological processes and are ideal non-invasive biomarkers. Here, we present the differential plasma exosomal proteome of a patient with EBV-HLH before vs. during treatment and with that of his healthy twin brother. A tandem mass tag-labeled LC-MS technique was employed for proteomic detection. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses indicated that differential proteomic profiles were related to virus infection, coagulopathy, nervous system dysfunction, imbalance of immune response, and abnormal liver function. The candidate biomarkers were first identified in the patient’s plasma exosomes at different treatment and follow-up time points. Then, 14 additional EBV-HLH exosome samples were used to verify six differentially expressed proteins. The upregulation of C-reactive protein, moesin, galectin three-binding protein, and heat shock cognate 71 kDa protein and the downregulation of plasminogen and fibronectin 1 could serve as potential biomarkers of EBV-HLH. This plasma exosomal proteomic analysis provides new insights into the diagnostic and therapeutic biomarkers of EBV-HLH.https://www.frontiersin.org/articles/10.3389/fmicb.2022.821311/fullhemophagocytic lymphohistiocytosisEpstein-Barr virusexosomesquantitative proteomicsbiomarker |
| spellingShingle | Yan Xie Yan Xie Yan Xie Yan Xie Li Yang Li Yang Li Yang Li Yang Pengfei Cao Pengfei Cao Shen Li Shen Li Shen Li Shen Li Wentao Zhang Wentao Zhang Wentao Zhang Wentao Zhang Wei Dang Wei Dang Wei Dang Wei Dang Shuyu Xin Shuyu Xin Shuyu Xin Shuyu Xin Mingjuan Jiang Mingjuan Jiang Mingjuan Jiang Mingjuan Jiang Yujie Xin Yujie Xin Yujie Xin Yujie Xin Jing Li Jing Li Jing Li Jing Li Sijing Long Sijing Long Sijing Long Sijing Long Yiwei Wang Yiwei Wang Yiwei Wang Yiwei Wang Senmiao Zhang Senmiao Zhang Senmiao Zhang Senmiao Zhang Yang Yang Yang Yang Yang Yang Yang Yang Jianhong Lu Jianhong Lu Jianhong Lu Jianhong Lu Plasma Exosomal Proteomic Pattern of Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis Frontiers in Microbiology hemophagocytic lymphohistiocytosis Epstein-Barr virus exosomes quantitative proteomics biomarker |
| title | Plasma Exosomal Proteomic Pattern of Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis |
| title_full | Plasma Exosomal Proteomic Pattern of Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis |
| title_fullStr | Plasma Exosomal Proteomic Pattern of Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis |
| title_full_unstemmed | Plasma Exosomal Proteomic Pattern of Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis |
| title_short | Plasma Exosomal Proteomic Pattern of Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis |
| title_sort | plasma exosomal proteomic pattern of epstein barr virus associated hemophagocytic lymphohistiocytosis |
| topic | hemophagocytic lymphohistiocytosis Epstein-Barr virus exosomes quantitative proteomics biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.821311/full |
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