Cervicovaginal microbiota and women’s health outcomes
The human cervicovaginal microbiome has an important role in the health and homoeostasis of the female reproductive tract. A eubiotic microbiome is typically dominated with lactic acid producing bacteria and is categorised into five community state types. Issues arise when the microbiome becomes dys...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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CSIRO Publishing
2021-01-01
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| Series: | Microbiology Australia |
| Online Access: | https://www.publish.csiro.au/ma/pdf/MA21022 |
| _version_ | 1797979866896793600 |
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| author | Wilhelmina M Huston Catherine Burke Ciara J Bryant |
| author_facet | Wilhelmina M Huston Catherine Burke Ciara J Bryant |
| author_sort | Wilhelmina M Huston |
| collection | DOAJ |
| description | The human cervicovaginal microbiome has an important role in the health and homoeostasis of the female reproductive tract. A eubiotic microbiome is typically dominated with lactic acid producing bacteria and is categorised into five community state types. Issues arise when the microbiome becomes dysbiotic, with the microbial composition shifting to contain a greater relative abundance of strict and facultative anaerobes. This shift will lead to several adverse changes in the vaginal environment including compromised epithelial cells, cell death, inflammation, and greater susceptibility to infection. These changes are associated with various adverse outcomes including infections, preterm birth, and infertility. In this review, we discuss how the cervicovaginal microbiome influences these outcomes and possible future directions of treatment and research. |
| first_indexed | 2024-04-11T05:45:40Z |
| format | Article |
| id | doaj.art-67ebb884d92f4766bca0db225a253bf0 |
| institution | Directory Open Access Journal |
| issn | 1324-4272 2201-9189 |
| language | English |
| last_indexed | 2024-04-11T05:45:40Z |
| publishDate | 2021-01-01 |
| publisher | CSIRO Publishing |
| record_format | Article |
| series | Microbiology Australia |
| spelling | doaj.art-67ebb884d92f4766bca0db225a253bf02022-12-22T04:42:14ZengCSIRO PublishingMicrobiology Australia1324-42722201-91892021-01-014226568MA21022Cervicovaginal microbiota and women’s health outcomesWilhelmina M Huston0Catherine Burke1Ciara J Bryant2School of Life Sciences, Faculty of Science, University of Technology Sydney, 15 Broadway, Ultimo, NSW 2007, Australia; and Tel.: +61 2 9514 3449; Email: Wilhelmina.Huston@uts.edu.auSchool of Life Sciences, Faculty of Science, University of Technology Sydney, 15 Broadway, Ultimo, NSW 2007, AustraliaSchool of Life Sciences, Faculty of Science, University of Technology Sydney, 15 Broadway, Ultimo, NSW 2007, AustraliaThe human cervicovaginal microbiome has an important role in the health and homoeostasis of the female reproductive tract. A eubiotic microbiome is typically dominated with lactic acid producing bacteria and is categorised into five community state types. Issues arise when the microbiome becomes dysbiotic, with the microbial composition shifting to contain a greater relative abundance of strict and facultative anaerobes. This shift will lead to several adverse changes in the vaginal environment including compromised epithelial cells, cell death, inflammation, and greater susceptibility to infection. These changes are associated with various adverse outcomes including infections, preterm birth, and infertility. In this review, we discuss how the cervicovaginal microbiome influences these outcomes and possible future directions of treatment and research.https://www.publish.csiro.au/ma/pdf/MA21022 |
| spellingShingle | Wilhelmina M Huston Catherine Burke Ciara J Bryant Cervicovaginal microbiota and women’s health outcomes Microbiology Australia |
| title | Cervicovaginal microbiota and women’s health outcomes |
| title_full | Cervicovaginal microbiota and women’s health outcomes |
| title_fullStr | Cervicovaginal microbiota and women’s health outcomes |
| title_full_unstemmed | Cervicovaginal microbiota and women’s health outcomes |
| title_short | Cervicovaginal microbiota and women’s health outcomes |
| title_sort | cervicovaginal microbiota and women s health outcomes |
| url | https://www.publish.csiro.au/ma/pdf/MA21022 |
| work_keys_str_mv | AT wilhelminamhuston cervicovaginalmicrobiotaandwomenshealthoutcomes AT catherineburke cervicovaginalmicrobiotaandwomenshealthoutcomes AT ciarajbryant cervicovaginalmicrobiotaandwomenshealthoutcomes |