Associations of rheumatoid arthritis and rheumatoid factor with mental health, sleep and cognition characteristics in the UK Biobank
Abstract While previous rheumatoid arthritis (RA) studies have focussed on cardiometabolic and lifestyle factors, less research has focussed on psychological variables including mood and cognitive health, and sleep. Cross-sectional analyses tested for associations between RA and RF+ (positive rheuma...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-22021-6 |
| _version_ | 1797983894254911488 |
|---|---|
| author | Ioana Stanciu Jana Anderson Stefan Siebert Daniel Mackay Donald M. Lyall |
| author_facet | Ioana Stanciu Jana Anderson Stefan Siebert Daniel Mackay Donald M. Lyall |
| author_sort | Ioana Stanciu |
| collection | DOAJ |
| description | Abstract While previous rheumatoid arthritis (RA) studies have focussed on cardiometabolic and lifestyle factors, less research has focussed on psychological variables including mood and cognitive health, and sleep. Cross-sectional analyses tested for associations between RA and RF+ (positive rheumatoid factor) vs. mental health (depression, anxiety, neuroticism), sleep variables and cognition scores in UK Biobank (total n = 484,064). Those RF+ were more likely to report longer sleep duration (β = 0.01, SE = 0.004, p < 0.01) and less likely to get up in the morning easily (OR 0.95, 95% CI 0.92–0.99, p = 0.01). Those reporting RA were more likely to score higher for neuroticism (β = 0.05, SE = 0.01, p < 0.001), to nap during the day (OR 1.10, 95% CI 1.06–1.14, p < 0.001), have insomnia (OR 1.28, 95% CI 1.22–1.35, p < 0.001), have slower reaction times (β = 0.02, SE = 0.008, p < 0.005) and score less for fluid intelligence (β = − 0.03, SE = 0.01, p < 0.05) and less likely to get up easily (OR 0.61, 95% CI 0.58–0.64, p < 0.001). The current study suggests that prevalent RA, and RF+ status are associated with differences in mental health, sleep, and cognition, highlighting the importance of addressing these aspects in clinical settings and future research. |
| first_indexed | 2024-04-11T06:54:36Z |
| format | Article |
| id | doaj.art-67ebf15a22bc48708cd1fc7c741f8799 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T06:54:36Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-67ebf15a22bc48708cd1fc7c741f87992022-12-22T04:39:04ZengNature PortfolioScientific Reports2045-23222022-11-011211710.1038/s41598-022-22021-6Associations of rheumatoid arthritis and rheumatoid factor with mental health, sleep and cognition characteristics in the UK BiobankIoana Stanciu0Jana Anderson1Stefan Siebert2Daniel Mackay3Donald M. Lyall4School of Health and Wellbeing, University of GlasgowSchool of Health and Wellbeing, University of GlasgowSchool of Inflammation and Immunity, University of GlasgowSchool of Health and Wellbeing, University of GlasgowSchool of Health and Wellbeing, University of GlasgowAbstract While previous rheumatoid arthritis (RA) studies have focussed on cardiometabolic and lifestyle factors, less research has focussed on psychological variables including mood and cognitive health, and sleep. Cross-sectional analyses tested for associations between RA and RF+ (positive rheumatoid factor) vs. mental health (depression, anxiety, neuroticism), sleep variables and cognition scores in UK Biobank (total n = 484,064). Those RF+ were more likely to report longer sleep duration (β = 0.01, SE = 0.004, p < 0.01) and less likely to get up in the morning easily (OR 0.95, 95% CI 0.92–0.99, p = 0.01). Those reporting RA were more likely to score higher for neuroticism (β = 0.05, SE = 0.01, p < 0.001), to nap during the day (OR 1.10, 95% CI 1.06–1.14, p < 0.001), have insomnia (OR 1.28, 95% CI 1.22–1.35, p < 0.001), have slower reaction times (β = 0.02, SE = 0.008, p < 0.005) and score less for fluid intelligence (β = − 0.03, SE = 0.01, p < 0.05) and less likely to get up easily (OR 0.61, 95% CI 0.58–0.64, p < 0.001). The current study suggests that prevalent RA, and RF+ status are associated with differences in mental health, sleep, and cognition, highlighting the importance of addressing these aspects in clinical settings and future research.https://doi.org/10.1038/s41598-022-22021-6 |
| spellingShingle | Ioana Stanciu Jana Anderson Stefan Siebert Daniel Mackay Donald M. Lyall Associations of rheumatoid arthritis and rheumatoid factor with mental health, sleep and cognition characteristics in the UK Biobank Scientific Reports |
| title | Associations of rheumatoid arthritis and rheumatoid factor with mental health, sleep and cognition characteristics in the UK Biobank |
| title_full | Associations of rheumatoid arthritis and rheumatoid factor with mental health, sleep and cognition characteristics in the UK Biobank |
| title_fullStr | Associations of rheumatoid arthritis and rheumatoid factor with mental health, sleep and cognition characteristics in the UK Biobank |
| title_full_unstemmed | Associations of rheumatoid arthritis and rheumatoid factor with mental health, sleep and cognition characteristics in the UK Biobank |
| title_short | Associations of rheumatoid arthritis and rheumatoid factor with mental health, sleep and cognition characteristics in the UK Biobank |
| title_sort | associations of rheumatoid arthritis and rheumatoid factor with mental health sleep and cognition characteristics in the uk biobank |
| url | https://doi.org/10.1038/s41598-022-22021-6 |
| work_keys_str_mv | AT ioanastanciu associationsofrheumatoidarthritisandrheumatoidfactorwithmentalhealthsleepandcognitioncharacteristicsintheukbiobank AT janaanderson associationsofrheumatoidarthritisandrheumatoidfactorwithmentalhealthsleepandcognitioncharacteristicsintheukbiobank AT stefansiebert associationsofrheumatoidarthritisandrheumatoidfactorwithmentalhealthsleepandcognitioncharacteristicsintheukbiobank AT danielmackay associationsofrheumatoidarthritisandrheumatoidfactorwithmentalhealthsleepandcognitioncharacteristicsintheukbiobank AT donaldmlyall associationsofrheumatoidarthritisandrheumatoidfactorwithmentalhealthsleepandcognitioncharacteristicsintheukbiobank |