Evaluation of long noncoding RNA (LncRNA) in pathogenesis of HELLP syndrome: diagnostic and future approach
HELLP syndrome is a disorder during pregnancy which is defined by elevation of liver enzymes, haemolysis, and low platelet count. This syndrome is a multifactorial one and both genetic and environmental components can have a crucial role in this syndrome’s pathogenesis. Long noncoding RNAs (lncRNAs)...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Journal of Obstetrics and Gynaecology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/01443615.2023.2174836 |
| _version_ | 1797685663788695552 |
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| author | Shahrzad Amirlatifi Zahra Kooshari Kiana Salmani Maryam Fallah Ziyarani Sepideh Azizi Elena Ghotbi Bita Zolali |
| author_facet | Shahrzad Amirlatifi Zahra Kooshari Kiana Salmani Maryam Fallah Ziyarani Sepideh Azizi Elena Ghotbi Bita Zolali |
| author_sort | Shahrzad Amirlatifi |
| collection | DOAJ |
| description | HELLP syndrome is a disorder during pregnancy which is defined by elevation of liver enzymes, haemolysis, and low platelet count. This syndrome is a multifactorial one and both genetic and environmental components can have a crucial role in this syndrome’s pathogenesis. Long noncoding RNAs (lncRNAs), are defined as long non-protein coding molecules (more than 200 nucleotides), which are functional units in most cellular processes such as cell cycle, differentiation, metabolism and some diseases progression. As these markers discovered, there has been some evidence that they have an important role in the function of some organs, such as placenta; therefore, alteration and dysregulation of these RNAs can develop or alleviate HELLP disorder. Although the role of lncRNAs has been shown in HELLP syndrome, the process is still unclear. In this review, our purpose is to evaluate the association between molecular mechanisms of lncRNAs and HELLP syndrome pathogenicity to elicit some novel approaches for HELLP diagnosis and treatment. |
| first_indexed | 2024-03-12T00:48:10Z |
| format | Article |
| id | doaj.art-67ebffdc28034bbbade9dab77440e35f |
| institution | Directory Open Access Journal |
| issn | 0144-3615 1364-6893 |
| language | English |
| last_indexed | 2024-03-12T00:48:10Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Obstetrics and Gynaecology |
| spelling | doaj.art-67ebffdc28034bbbade9dab77440e35f2023-09-14T15:29:13ZengTaylor & Francis GroupJournal of Obstetrics and Gynaecology0144-36151364-68932023-12-0143110.1080/01443615.2023.21748362174836Evaluation of long noncoding RNA (LncRNA) in pathogenesis of HELLP syndrome: diagnostic and future approachShahrzad Amirlatifi0Zahra Kooshari1Kiana Salmani2Maryam Fallah Ziyarani3Sepideh Azizi4Elena Ghotbi5Bita Zolali6Clinical Research Development unit (SHACRDU), School of Medicine, Iran University of Medical SciencesClinical Research Development unit (SHACRDU), School of Medicine, Iran University of Medical SciencesDepartment of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad UniversityDepartment of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad UniversityClinical Research Development unit (SHACRDU), School of Medicine, Iran University of Medical SciencesPreventative Gynecology Research Center, Shahid Beheshti University of Medical ScienceClinical Research Development unit (SHACRDU), School of Medicine, Iran University of Medical SciencesHELLP syndrome is a disorder during pregnancy which is defined by elevation of liver enzymes, haemolysis, and low platelet count. This syndrome is a multifactorial one and both genetic and environmental components can have a crucial role in this syndrome’s pathogenesis. Long noncoding RNAs (lncRNAs), are defined as long non-protein coding molecules (more than 200 nucleotides), which are functional units in most cellular processes such as cell cycle, differentiation, metabolism and some diseases progression. As these markers discovered, there has been some evidence that they have an important role in the function of some organs, such as placenta; therefore, alteration and dysregulation of these RNAs can develop or alleviate HELLP disorder. Although the role of lncRNAs has been shown in HELLP syndrome, the process is still unclear. In this review, our purpose is to evaluate the association between molecular mechanisms of lncRNAs and HELLP syndrome pathogenicity to elicit some novel approaches for HELLP diagnosis and treatment.http://dx.doi.org/10.1080/01443615.2023.2174836hellp syndromelncrnadiagnosticsignalingmolecular pathwaypathogenesis |
| spellingShingle | Shahrzad Amirlatifi Zahra Kooshari Kiana Salmani Maryam Fallah Ziyarani Sepideh Azizi Elena Ghotbi Bita Zolali Evaluation of long noncoding RNA (LncRNA) in pathogenesis of HELLP syndrome: diagnostic and future approach Journal of Obstetrics and Gynaecology hellp syndrome lncrna diagnostic signaling molecular pathway pathogenesis |
| title | Evaluation of long noncoding RNA (LncRNA) in pathogenesis of HELLP syndrome: diagnostic and future approach |
| title_full | Evaluation of long noncoding RNA (LncRNA) in pathogenesis of HELLP syndrome: diagnostic and future approach |
| title_fullStr | Evaluation of long noncoding RNA (LncRNA) in pathogenesis of HELLP syndrome: diagnostic and future approach |
| title_full_unstemmed | Evaluation of long noncoding RNA (LncRNA) in pathogenesis of HELLP syndrome: diagnostic and future approach |
| title_short | Evaluation of long noncoding RNA (LncRNA) in pathogenesis of HELLP syndrome: diagnostic and future approach |
| title_sort | evaluation of long noncoding rna lncrna in pathogenesis of hellp syndrome diagnostic and future approach |
| topic | hellp syndrome lncrna diagnostic signaling molecular pathway pathogenesis |
| url | http://dx.doi.org/10.1080/01443615.2023.2174836 |
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