Characterization and Chemical Synthesis of Cm39 (α-KTx 4.8): A Scorpion Toxin That Inhibits Voltage-Gated K<sup>+</sup> Channel K<sub>V</sub>1.2 and Small- and Intermediate-Conductance Ca<sup>2+</sup>-Activated K<sup>+</sup> Channels K<sub>Ca</sub>2.2 and K<sub>Ca</sub>3.1

Characterization and Chemical Synthesis of Cm39 (α-KTx 4.8): A Scorpion Toxin That Inhibits Voltage-Gated K<sup>+</sup> Channel K<sub>V</sub>1.2 and Small- and Intermediate-Conductance Ca<sup>2+</sup>-Activated K<sup>+</sup> Channels K<sub>Ca</sub>2.2 and K<sub>Ca</sub>3.1

A novel peptide, Cm39, was identified in the venom of the scorpion <i>Centruroides margaritatus</i>. Its primary structure was determined. It consists of 37 amino acid residues with a MW of 3980.2 Da. The full chemical synthesis and proper folding of Cm39 was obtained. Based on amino aci...

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Bibliographic Details
Main Authors: Muhammad Umair Naseem, Georgina Gurrola-Briones, Margarita R. Romero-Imbachi, Jesus Borrego, Edson Carcamo-Noriega, José Beltrán-Vidal, Fernando Z. Zamudio, Kashmala Shakeel, Lourival Domingos Possani, Gyorgy Panyi
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Toxins
Subjects:
Cm39
scorpion toxin
<i>Centruroides margaritatus</i>
K<sub>V</sub>1.2
K<sub>Ca</sub>2.2
K<sub>Ca</sub>3.1
Online Access:https://www.mdpi.com/2072-6651/15/1/41

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