Effect of Centella asiatica on cognitive deficits caused in trimethyltin-induced neurotoxicity model mice
Centella asiatica (L.) Urb. is a nootropic that has been used medicinally for centuries. The present study investigates the anti-dementia effect of an n-butanol extract of Centella asiatica in a mouse model of neurodegeneration caused by trimethyltin (TMT). Mice were administered Centella asiatica...
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| Format: | Article |
| Language: | English |
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Vietnam Ministry of Science and Technology
2021-03-01
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| Series: | Vietnam Journal of Science, Technology and Engineering |
| Subjects: | |
| Online Access: | https://vietnamscience.vjst.vn/index.php/vjste/article/view/15 |
| _version_ | 1797937755593900032 |
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| author | Hang Thi Nguyet Pham Hong Nguyen Tran Xoan Thi Le Khoi Minh Nguyen Hiep Tuan Nguyen Lap Thi Nguyen Folk R. William |
| author_facet | Hang Thi Nguyet Pham Hong Nguyen Tran Xoan Thi Le Khoi Minh Nguyen Hiep Tuan Nguyen Lap Thi Nguyen Folk R. William |
| author_sort | Hang Thi Nguyet Pham |
| collection | DOAJ |
| description |
Centella asiatica (L.) Urb. is a nootropic that has been used medicinally for centuries. The present study investigates the anti-dementia effect of an n-butanol extract of Centella asiatica in a mouse model of neurodegeneration caused by trimethyltin (TMT). Mice were administered Centella asiatica extract (150 and 540 mg/kg) or a reference drug, tacrine (2.1 mg/kg), daily for one week before TMT injection and during tests to analyse spatial short-term and spatial working memory. The treatment of mice with TMT caused deficits in short-term spatial working memory and decreased the number of pyramidal cells in the hippocampal CA1 and CA3 regions elucidated by Nissl staining at 28 d post-TMT treatment. The administration of Centella asiatica extract or tacrine significantly attenuated the behavioural and histochemical changes caused by TMT. These results suggest that Centella asiatica extract improved memory deficits partly by protecting hippocampal neurons from TMT-induced damage.
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| first_indexed | 2024-04-10T18:49:15Z |
| format | Article |
| id | doaj.art-67ee93fd01a2440cb9c722dccd0c3705 |
| institution | Directory Open Access Journal |
| issn | 2525-2461 2615-9937 |
| language | English |
| last_indexed | 2024-04-10T18:49:15Z |
| publishDate | 2021-03-01 |
| publisher | Vietnam Ministry of Science and Technology |
| record_format | Article |
| series | Vietnam Journal of Science, Technology and Engineering |
| spelling | doaj.art-67ee93fd01a2440cb9c722dccd0c37052023-02-01T08:20:08ZengVietnam Ministry of Science and TechnologyVietnam Journal of Science, Technology and Engineering2525-24612615-99372021-03-0163110.31276/VJSTE.63(1).59-63Effect of Centella asiatica on cognitive deficits caused in trimethyltin-induced neurotoxicity model miceHang Thi Nguyet Pham0Hong Nguyen Tran1Xoan Thi Le2Khoi Minh Nguyen3Hiep Tuan Nguyen4Lap Thi Nguyen5Folk R. William6National Institute of Medicinal Materials, VietnamNational Institute of Medicinal Materials, VietnamNational Institute of Medicinal Materials, VietnamNational Institute of Medicinal Materials, VietnamNational Institute of Medicinal Materials, VietnamHanoi Pharmacy University, VietnamUniversity of Missouri, USA Centella asiatica (L.) Urb. is a nootropic that has been used medicinally for centuries. The present study investigates the anti-dementia effect of an n-butanol extract of Centella asiatica in a mouse model of neurodegeneration caused by trimethyltin (TMT). Mice were administered Centella asiatica extract (150 and 540 mg/kg) or a reference drug, tacrine (2.1 mg/kg), daily for one week before TMT injection and during tests to analyse spatial short-term and spatial working memory. The treatment of mice with TMT caused deficits in short-term spatial working memory and decreased the number of pyramidal cells in the hippocampal CA1 and CA3 regions elucidated by Nissl staining at 28 d post-TMT treatment. The administration of Centella asiatica extract or tacrine significantly attenuated the behavioural and histochemical changes caused by TMT. These results suggest that Centella asiatica extract improved memory deficits partly by protecting hippocampal neurons from TMT-induced damage. https://vietnamscience.vjst.vn/index.php/vjste/article/view/15Centella asiaticadementiahippocampusneuroprotectiontrimethyltin |
| spellingShingle | Hang Thi Nguyet Pham Hong Nguyen Tran Xoan Thi Le Khoi Minh Nguyen Hiep Tuan Nguyen Lap Thi Nguyen Folk R. William Effect of Centella asiatica on cognitive deficits caused in trimethyltin-induced neurotoxicity model mice Vietnam Journal of Science, Technology and Engineering Centella asiatica dementia hippocampus neuroprotection trimethyltin |
| title | Effect of Centella asiatica on cognitive deficits caused in trimethyltin-induced neurotoxicity model mice |
| title_full | Effect of Centella asiatica on cognitive deficits caused in trimethyltin-induced neurotoxicity model mice |
| title_fullStr | Effect of Centella asiatica on cognitive deficits caused in trimethyltin-induced neurotoxicity model mice |
| title_full_unstemmed | Effect of Centella asiatica on cognitive deficits caused in trimethyltin-induced neurotoxicity model mice |
| title_short | Effect of Centella asiatica on cognitive deficits caused in trimethyltin-induced neurotoxicity model mice |
| title_sort | effect of centella asiatica on cognitive deficits caused in trimethyltin induced neurotoxicity model mice |
| topic | Centella asiatica dementia hippocampus neuroprotection trimethyltin |
| url | https://vietnamscience.vjst.vn/index.php/vjste/article/view/15 |
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