New insights into nanotherapeutics for periodontitis: a triple concerto of antimicrobial activity, immunomodulation and periodontium regeneration
Abstract Periodontitis is a chronic inflammatory disease caused by the local microbiome and the host immune response, resulting in periodontal structure damage and even tooth loss. Scaling and root planning combined with antibiotics are the conventional means of nonsurgical treatment of periodontiti...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-023-02261-y |
| _version_ | 1797362920108064768 |
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| author | Jiaxin Li Yuxiao Wang Maomao Tang Chengdong Zhang Yachen Fei Meng Li Mengjie Li Shuangying Gui Jian Guo |
| author_facet | Jiaxin Li Yuxiao Wang Maomao Tang Chengdong Zhang Yachen Fei Meng Li Mengjie Li Shuangying Gui Jian Guo |
| author_sort | Jiaxin Li |
| collection | DOAJ |
| description | Abstract Periodontitis is a chronic inflammatory disease caused by the local microbiome and the host immune response, resulting in periodontal structure damage and even tooth loss. Scaling and root planning combined with antibiotics are the conventional means of nonsurgical treatment of periodontitis, but they are insufficient to fully heal periodontitis due to intractable bacterial attachment and drug resistance. Novel and effective therapeutic options in clinical drug therapy remain scarce. Nanotherapeutics achieve stable cell targeting, oral retention and smart release by great flexibility in changing the chemical composition or physical characteristics of nanoparticles. Meanwhile, the protectiveness and high surface area to volume ratio of nanoparticles enable high drug loading, ensuring a remarkable therapeutic efficacy. Currently, the combination of advanced nanoparticles and novel therapeutic strategies is the most active research area in periodontitis treatment. In this review, we first introduce the pathogenesis of periodontitis, and then summarize the state-of-the-art nanotherapeutic strategies based on the triple concerto of antibacterial activity, immunomodulation and periodontium regeneration, particularly focusing on the therapeutic mechanism and ingenious design of nanomedicines. Finally, the challenges and prospects of nano therapy for periodontitis are discussed from the perspective of current treatment problems and future development trends. Graphical Abstract |
| first_indexed | 2024-03-08T16:14:20Z |
| format | Article |
| id | doaj.art-67ef1240ad714336b836ca7be213b1d2 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-03-08T16:14:20Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-67ef1240ad714336b836ca7be213b1d22024-01-07T12:43:16ZengBMCJournal of Nanobiotechnology1477-31552024-01-0122113410.1186/s12951-023-02261-yNew insights into nanotherapeutics for periodontitis: a triple concerto of antimicrobial activity, immunomodulation and periodontium regenerationJiaxin Li0Yuxiao Wang1Maomao Tang2Chengdong Zhang3Yachen Fei4Meng Li5Mengjie Li6Shuangying Gui7Jian Guo8Department of Pharmacy, Anhui University of Chinese MedicineDepartment of Pharmacy, Anhui University of Chinese MedicineDepartment of Pharmacy, Anhui University of Chinese MedicineDepartment of Pharmacy, Anhui University of Chinese MedicineDepartment of Pharmacy, Anhui University of Chinese MedicineDepartment of Pharmacy, Anhui University of Chinese MedicineDepartment of Pharmacy, Anhui University of Chinese MedicineDepartment of Pharmacy, Anhui University of Chinese MedicineDepartment of Pharmacy, Anhui University of Chinese MedicineAbstract Periodontitis is a chronic inflammatory disease caused by the local microbiome and the host immune response, resulting in periodontal structure damage and even tooth loss. Scaling and root planning combined with antibiotics are the conventional means of nonsurgical treatment of periodontitis, but they are insufficient to fully heal periodontitis due to intractable bacterial attachment and drug resistance. Novel and effective therapeutic options in clinical drug therapy remain scarce. Nanotherapeutics achieve stable cell targeting, oral retention and smart release by great flexibility in changing the chemical composition or physical characteristics of nanoparticles. Meanwhile, the protectiveness and high surface area to volume ratio of nanoparticles enable high drug loading, ensuring a remarkable therapeutic efficacy. Currently, the combination of advanced nanoparticles and novel therapeutic strategies is the most active research area in periodontitis treatment. In this review, we first introduce the pathogenesis of periodontitis, and then summarize the state-of-the-art nanotherapeutic strategies based on the triple concerto of antibacterial activity, immunomodulation and periodontium regeneration, particularly focusing on the therapeutic mechanism and ingenious design of nanomedicines. Finally, the challenges and prospects of nano therapy for periodontitis are discussed from the perspective of current treatment problems and future development trends. Graphical Abstracthttps://doi.org/10.1186/s12951-023-02261-yPeriodontitisNanotherapeuticsAntimicrobial activityImmunomodulationPeriodontium regenerationSynergistic therapy |
| spellingShingle | Jiaxin Li Yuxiao Wang Maomao Tang Chengdong Zhang Yachen Fei Meng Li Mengjie Li Shuangying Gui Jian Guo New insights into nanotherapeutics for periodontitis: a triple concerto of antimicrobial activity, immunomodulation and periodontium regeneration Journal of Nanobiotechnology Periodontitis Nanotherapeutics Antimicrobial activity Immunomodulation Periodontium regeneration Synergistic therapy |
| title | New insights into nanotherapeutics for periodontitis: a triple concerto of antimicrobial activity, immunomodulation and periodontium regeneration |
| title_full | New insights into nanotherapeutics for periodontitis: a triple concerto of antimicrobial activity, immunomodulation and periodontium regeneration |
| title_fullStr | New insights into nanotherapeutics for periodontitis: a triple concerto of antimicrobial activity, immunomodulation and periodontium regeneration |
| title_full_unstemmed | New insights into nanotherapeutics for periodontitis: a triple concerto of antimicrobial activity, immunomodulation and periodontium regeneration |
| title_short | New insights into nanotherapeutics for periodontitis: a triple concerto of antimicrobial activity, immunomodulation and periodontium regeneration |
| title_sort | new insights into nanotherapeutics for periodontitis a triple concerto of antimicrobial activity immunomodulation and periodontium regeneration |
| topic | Periodontitis Nanotherapeutics Antimicrobial activity Immunomodulation Periodontium regeneration Synergistic therapy |
| url | https://doi.org/10.1186/s12951-023-02261-y |
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