Cucurbitacin E induces cell cycle G2/M phase arrest and apoptosis in triple negative breast cancer.
Triple negative breast cancer (TNBC) is a highly aggressive form of breast cancer resistant to many common treatments. In this study, we compared the effects of 12 phytochemical drugs on four cancer cell lines, and noticed that Cucurbitacin E (CuE) significantly inhibited TNBC cell growth by inducin...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4114842?pdf=render |
| _version_ | 1819017382656475136 |
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| author | Yanjie Kong Jianchao Chen Zhongmei Zhou Houjun Xia Ming-Hua Qiu Ceshi Chen |
| author_facet | Yanjie Kong Jianchao Chen Zhongmei Zhou Houjun Xia Ming-Hua Qiu Ceshi Chen |
| author_sort | Yanjie Kong |
| collection | DOAJ |
| description | Triple negative breast cancer (TNBC) is a highly aggressive form of breast cancer resistant to many common treatments. In this study, we compared the effects of 12 phytochemical drugs on four cancer cell lines, and noticed that Cucurbitacin E (CuE) significantly inhibited TNBC cell growth by inducing cell cycle G2/M phase arrest and apoptosis. CuE reduced expression of Cyclin D1, Survivin, XIAP, Bcl2, and Mcl-1 in MDA-MB-468 and SW527, and within MDA-MB-468, CuE significantly increased activation of JNK and inhibited activation of AKT and ERK. Collectively, these results suggest that CuE may be a viable compound for developing novel TNBC therapeutics. |
| first_indexed | 2024-12-21T03:02:38Z |
| format | Article |
| id | doaj.art-67ef4fffe2e64e49b427c9dde9112f03 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T03:02:38Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-67ef4fffe2e64e49b427c9dde9112f032022-12-21T19:18:09ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0197e10376010.1371/journal.pone.0103760Cucurbitacin E induces cell cycle G2/M phase arrest and apoptosis in triple negative breast cancer.Yanjie KongJianchao ChenZhongmei ZhouHoujun XiaMing-Hua QiuCeshi ChenTriple negative breast cancer (TNBC) is a highly aggressive form of breast cancer resistant to many common treatments. In this study, we compared the effects of 12 phytochemical drugs on four cancer cell lines, and noticed that Cucurbitacin E (CuE) significantly inhibited TNBC cell growth by inducing cell cycle G2/M phase arrest and apoptosis. CuE reduced expression of Cyclin D1, Survivin, XIAP, Bcl2, and Mcl-1 in MDA-MB-468 and SW527, and within MDA-MB-468, CuE significantly increased activation of JNK and inhibited activation of AKT and ERK. Collectively, these results suggest that CuE may be a viable compound for developing novel TNBC therapeutics.http://europepmc.org/articles/PMC4114842?pdf=render |
| spellingShingle | Yanjie Kong Jianchao Chen Zhongmei Zhou Houjun Xia Ming-Hua Qiu Ceshi Chen Cucurbitacin E induces cell cycle G2/M phase arrest and apoptosis in triple negative breast cancer. PLoS ONE |
| title | Cucurbitacin E induces cell cycle G2/M phase arrest and apoptosis in triple negative breast cancer. |
| title_full | Cucurbitacin E induces cell cycle G2/M phase arrest and apoptosis in triple negative breast cancer. |
| title_fullStr | Cucurbitacin E induces cell cycle G2/M phase arrest and apoptosis in triple negative breast cancer. |
| title_full_unstemmed | Cucurbitacin E induces cell cycle G2/M phase arrest and apoptosis in triple negative breast cancer. |
| title_short | Cucurbitacin E induces cell cycle G2/M phase arrest and apoptosis in triple negative breast cancer. |
| title_sort | cucurbitacin e induces cell cycle g2 m phase arrest and apoptosis in triple negative breast cancer |
| url | http://europepmc.org/articles/PMC4114842?pdf=render |
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