Evaluation of scrotal pigmentation in infants with spectroscopic method and its correlation with 17-hydroxyprogesterone blood levels
Aim: To evaluate the scrotal melanin density in infants using spectrometry and to determine the correlation between spectrometric evaluations, physical examinations and blood 17-hydroxyprogesterone levels.Material and methods: A total of 40 infants were enrolled to the study, 22 of whom were diagnos...
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| Format: | Article |
| Language: | English |
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Alanya Alaaddin Keykubat University
2020-03-01
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| Series: | Acta Medica Alanya |
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| Online Access: | https://dergipark.org.tr/en/pub/medalanya/issue/52507/569972?publisher=alku |
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| author | Abdurrahman Erdem Basaran Aslınur Sırcan-küçüksayan Murat Canpolat Sevtap Veli̇pasaoğlu |
| author_facet | Abdurrahman Erdem Basaran Aslınur Sırcan-küçüksayan Murat Canpolat Sevtap Veli̇pasaoğlu |
| author_sort | Abdurrahman Erdem Basaran |
| collection | DOAJ |
| description | Aim: To evaluate the scrotal melanin density in infants using spectrometry and to determine the correlation between spectrometric evaluations, physical examinations and blood 17-hydroxyprogesterone levels.Material and methods: A total of 40 infants were enrolled to the study, 22 of whom were diagnosed by a physician as having scrotal hyperpigmentation and 18 with normal scrotal pigmentation, who were admitted for the evaluation of prolonged jaundice. Age, gestational week, birth weight and scrotal pigmentation noted by the physician were recorded. Spectral data were acquired from scrotum and thigh. A correlation between the spectral measurements and the blood 17-hydroxyprogesterone level was determined by comparing spectral value in the wavelength range of 620-800 nm and 17-hydroxyprogesterone levels. Results: No statistically significant difference was observed between the groups who were categorized by the physician as having “hyperpigmented” or “normal” scrotal color in terms of the infant’s age, gestational week, birth weight, 17-hydroxyprogesterone level or spectrometric values. We observed a strong correlation between 17-hydroxyprogesterone levels and spectrometric values in all groups.Conclusion: This preliminary study is the first one in the literature which evaluates scrotal pigmentation with an objective spectrometric method and determines its relationship with 17-hydroxyprogesterone levels. Further studies are needed to employ this method as a non-invasive, indirect screening test for the screening of congenital adrenal hyperplasia in male infants. |
| first_indexed | 2024-04-10T14:31:40Z |
| format | Article |
| id | doaj.art-67f51e52e94742f8ac7f989ae84c4bbc |
| institution | Directory Open Access Journal |
| issn | 2587-0319 |
| language | English |
| last_indexed | 2024-04-10T14:31:40Z |
| publishDate | 2020-03-01 |
| publisher | Alanya Alaaddin Keykubat University |
| record_format | Article |
| series | Acta Medica Alanya |
| spelling | doaj.art-67f51e52e94742f8ac7f989ae84c4bbc2023-02-15T16:08:47ZengAlanya Alaaddin Keykubat UniversityActa Medica Alanya2587-03192020-03-0141101510.30565/medalanya.569972727Evaluation of scrotal pigmentation in infants with spectroscopic method and its correlation with 17-hydroxyprogesterone blood levelsAbdurrahman Erdem BasaranAslınur Sırcan-küçüksayan0Murat Canpolat1Sevtap Veli̇pasaoğlu2ALANYA ALAADDIN KEYKUBAT UNIVERSITYAKDENIZ UNIVERSITYAKDENIZ UNIVERSITYAim: To evaluate the scrotal melanin density in infants using spectrometry and to determine the correlation between spectrometric evaluations, physical examinations and blood 17-hydroxyprogesterone levels.Material and methods: A total of 40 infants were enrolled to the study, 22 of whom were diagnosed by a physician as having scrotal hyperpigmentation and 18 with normal scrotal pigmentation, who were admitted for the evaluation of prolonged jaundice. Age, gestational week, birth weight and scrotal pigmentation noted by the physician were recorded. Spectral data were acquired from scrotum and thigh. A correlation between the spectral measurements and the blood 17-hydroxyprogesterone level was determined by comparing spectral value in the wavelength range of 620-800 nm and 17-hydroxyprogesterone levels. Results: No statistically significant difference was observed between the groups who were categorized by the physician as having “hyperpigmented” or “normal” scrotal color in terms of the infant’s age, gestational week, birth weight, 17-hydroxyprogesterone level or spectrometric values. We observed a strong correlation between 17-hydroxyprogesterone levels and spectrometric values in all groups.Conclusion: This preliminary study is the first one in the literature which evaluates scrotal pigmentation with an objective spectrometric method and determines its relationship with 17-hydroxyprogesterone levels. Further studies are needed to employ this method as a non-invasive, indirect screening test for the screening of congenital adrenal hyperplasia in male infants.https://dergipark.org.tr/en/pub/medalanya/issue/52507/569972?publisher=alkucongenital adrenal hyperplasiaspectrometryscrotal pigmentation17-hydroxyprogesteronespectroscopic methodkonjenital adrenal hiperplazispektrometreskrotal pigmentasyon17-hidroksiprogesteronspektroskopik yöntem |
| spellingShingle | Abdurrahman Erdem Basaran Aslınur Sırcan-küçüksayan Murat Canpolat Sevtap Veli̇pasaoğlu Evaluation of scrotal pigmentation in infants with spectroscopic method and its correlation with 17-hydroxyprogesterone blood levels Acta Medica Alanya congenital adrenal hyperplasia spectrometry scrotal pigmentation 17-hydroxyprogesterone spectroscopic method konjenital adrenal hiperplazi spektrometre skrotal pigmentasyon 17-hidroksiprogesteron spektroskopik yöntem |
| title | Evaluation of scrotal pigmentation in infants with spectroscopic method and its correlation with 17-hydroxyprogesterone blood levels |
| title_full | Evaluation of scrotal pigmentation in infants with spectroscopic method and its correlation with 17-hydroxyprogesterone blood levels |
| title_fullStr | Evaluation of scrotal pigmentation in infants with spectroscopic method and its correlation with 17-hydroxyprogesterone blood levels |
| title_full_unstemmed | Evaluation of scrotal pigmentation in infants with spectroscopic method and its correlation with 17-hydroxyprogesterone blood levels |
| title_short | Evaluation of scrotal pigmentation in infants with spectroscopic method and its correlation with 17-hydroxyprogesterone blood levels |
| title_sort | evaluation of scrotal pigmentation in infants with spectroscopic method and its correlation with 17 hydroxyprogesterone blood levels |
| topic | congenital adrenal hyperplasia spectrometry scrotal pigmentation 17-hydroxyprogesterone spectroscopic method konjenital adrenal hiperplazi spektrometre skrotal pigmentasyon 17-hidroksiprogesteron spektroskopik yöntem |
| url | https://dergipark.org.tr/en/pub/medalanya/issue/52507/569972?publisher=alku |
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