Digit-length ratios (2D:4D) as a phenotypic indicator of in utero androgen exposure is not prognostic for androgenic alopecia: a descriptive-analytic study of 1200 Iranian men
The etiology of androgenic alopecia (AGA) involves several factors, including genetics, androgens, age and nutrition. Digit-length ratio of the index and ring finger (2D:4D) is an indicator of prenatal exposure to sex hormones. There is a paucity of studies that systemically review the possible posi...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2016-06-01
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| Series: | Dermatology Reports |
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| Online Access: | http://www.pagepress.org/journals/index.php/dr/article/view/6386 |
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| author | Amir Feily Masoomeh Hosseinpoor Ali Bakhti Mohamad Nekuyi Saeed Sobhanian Zahra Fathinezhad Reza Sahraei Marigdalia K. Ramirez-Fort |
| author_facet | Amir Feily Masoomeh Hosseinpoor Ali Bakhti Mohamad Nekuyi Saeed Sobhanian Zahra Fathinezhad Reza Sahraei Marigdalia K. Ramirez-Fort |
| author_sort | Amir Feily |
| collection | DOAJ |
| description | The etiology of androgenic alopecia (AGA) involves several factors, including genetics, androgens, age and nutrition. Digit-length ratio of the index and ring finger (2D:4D) is an indicator of prenatal exposure to sex hormones. There is a paucity of studies that systemically review the possible positive predictive value of 2D:4D in the development of AGA. We performed a single-site, descriptive-analytical study among a racially homogeneous population. Our results revealed that no significant association was determined between right 2D:4D and AGA severity within our entire population (P=0.384, r=0.025), however a positive correlation coefficient was identified in subjects above the age of 40. Based on the receiver operating characteristic curve analysis, 2D:4D does not predict the development of AGA. AGA is truly a multifactorial disease. Further, our findings suggest that increased <em>in utero</em> exposure to androgens as a fetus does not predispose men to develop AGA. |
| first_indexed | 2024-12-11T15:52:10Z |
| format | Article |
| id | doaj.art-67f89c46000d458a85f72bb64b96fd51 |
| institution | Directory Open Access Journal |
| issn | 2036-7392 2036-7406 |
| language | English |
| last_indexed | 2024-12-11T15:52:10Z |
| publishDate | 2016-06-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Dermatology Reports |
| spelling | doaj.art-67f89c46000d458a85f72bb64b96fd512022-12-22T00:59:32ZengPAGEPress PublicationsDermatology Reports2036-73922036-74062016-06-018110.4081/dr.2016.63863335Digit-length ratios (2D:4D) as a phenotypic indicator of in utero androgen exposure is not prognostic for androgenic alopecia: a descriptive-analytic study of 1200 Iranian menAmir Feily0Masoomeh Hosseinpoor1Ali Bakhti2Mohamad Nekuyi3Saeed Sobhanian4Zahra Fathinezhad5Reza Sahraei6Marigdalia K. Ramirez-Fort7Department of Dermatology, Jahrom University of Medical Sciences, JahromDepartment of Dermatology, Jahrom University of Medical Sciences, JahromDepartment of Dermatology, Jahrom University of Medical Sciences, JahromDepartment of Dermatology, Jahrom University of Medical Sciences, JahromHormozgan University of Medical Sciences, BandarabasDepartment of Community Health, Jahrom University of Medical Sciences, JahromDepartment of Anesthesiology, Jahrom University of Medical Sciences, JahromDepartment of Dermatology, Tufts Medical Center, Boston, MAThe etiology of androgenic alopecia (AGA) involves several factors, including genetics, androgens, age and nutrition. Digit-length ratio of the index and ring finger (2D:4D) is an indicator of prenatal exposure to sex hormones. There is a paucity of studies that systemically review the possible positive predictive value of 2D:4D in the development of AGA. We performed a single-site, descriptive-analytical study among a racially homogeneous population. Our results revealed that no significant association was determined between right 2D:4D and AGA severity within our entire population (P=0.384, r=0.025), however a positive correlation coefficient was identified in subjects above the age of 40. Based on the receiver operating characteristic curve analysis, 2D:4D does not predict the development of AGA. AGA is truly a multifactorial disease. Further, our findings suggest that increased <em>in utero</em> exposure to androgens as a fetus does not predispose men to develop AGA.http://www.pagepress.org/journals/index.php/dr/article/view/6386Androgenic alopeciahair lossdigitlength ratiopredictive value |
| spellingShingle | Amir Feily Masoomeh Hosseinpoor Ali Bakhti Mohamad Nekuyi Saeed Sobhanian Zahra Fathinezhad Reza Sahraei Marigdalia K. Ramirez-Fort Digit-length ratios (2D:4D) as a phenotypic indicator of in utero androgen exposure is not prognostic for androgenic alopecia: a descriptive-analytic study of 1200 Iranian men Dermatology Reports Androgenic alopecia hair loss digitlength ratio predictive value |
| title | Digit-length ratios (2D:4D) as a phenotypic indicator of in utero androgen exposure is not prognostic for androgenic alopecia: a descriptive-analytic study of 1200 Iranian men |
| title_full | Digit-length ratios (2D:4D) as a phenotypic indicator of in utero androgen exposure is not prognostic for androgenic alopecia: a descriptive-analytic study of 1200 Iranian men |
| title_fullStr | Digit-length ratios (2D:4D) as a phenotypic indicator of in utero androgen exposure is not prognostic for androgenic alopecia: a descriptive-analytic study of 1200 Iranian men |
| title_full_unstemmed | Digit-length ratios (2D:4D) as a phenotypic indicator of in utero androgen exposure is not prognostic for androgenic alopecia: a descriptive-analytic study of 1200 Iranian men |
| title_short | Digit-length ratios (2D:4D) as a phenotypic indicator of in utero androgen exposure is not prognostic for androgenic alopecia: a descriptive-analytic study of 1200 Iranian men |
| title_sort | digit length ratios 2d 4d as a phenotypic indicator of in utero androgen exposure is not prognostic for androgenic alopecia a descriptive analytic study of 1200 iranian men |
| topic | Androgenic alopecia hair loss digitlength ratio predictive value |
| url | http://www.pagepress.org/journals/index.php/dr/article/view/6386 |
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