Endothelial cells are a key target of IFN-g during response to combined PD-1/CTLA-4 ICB treatment in a mouse model of bladder cancer

Endothelial cells are a key target of IFN-g during response to combined PD-1/CTLA-4 ICB treatment in a mouse model of bladder cancer

Summary: To explore mechanisms of response to combined PD-1/CTLA-4 immune checkpoint blockade (ICB) treatment in individual cell types, we generated scRNA-seq using a mouse model of invasive urothelial carcinoma with three conditions: untreated tumor, treated tumor, and tumor treated after CD4+ T ce...

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Bibliographic Details
Main Authors: Sharon L. Freshour, Timothy H.-P. Chen, Bryan Fisk, Haolin Shen, Matthew Mosior, Zachary L. Skidmore, Catrina Fronick, Jennifer K. Bolzenius, Obi L. Griffith, Vivek K. Arora, Malachi Griffith
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:iScience
Subjects:
Oncology
Immunology
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422302014X

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