Pathological phenotypes of astrocytes in Alzheimer’s disease
Abstract Astrocytes are involved in various processes in the central nervous system (CNS). As the most abundant cell type in the CNS, astrocytes play an essential role in neuronal maintenance and support, synaptic activity, neuronal metabolism, and amyloid-beta (Aβ) clearance. Alzheimer’s disease (A...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2024-01-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-023-01148-0 |
| _version_ | 1827328513382809600 |
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| author | Junhyung Kim Ik Dong Yoo Jaejoon Lim Jong-Seok Moon |
| author_facet | Junhyung Kim Ik Dong Yoo Jaejoon Lim Jong-Seok Moon |
| author_sort | Junhyung Kim |
| collection | DOAJ |
| description | Abstract Astrocytes are involved in various processes in the central nervous system (CNS). As the most abundant cell type in the CNS, astrocytes play an essential role in neuronal maintenance and support, synaptic activity, neuronal metabolism, and amyloid-beta (Aβ) clearance. Alzheimer’s disease (AD) is a neurodegenerative disorder associated with cognitive and behavioral impairment. The transformation of astrocytes is involved in various neurodegenerative diseases, such as AD. Since astrocytes have functional diversity and morphological and physiological heterogeneity in the CNS, AD-related astrocytes might show various pathological phenotypes during AD. Astrocytes developing pathological phenotypes could contribute to AD progression. In this review, we provide an overview of the pathological phenotypes of astrocytes in the context of AD, highlighting recent findings in human and mouse AD. |
| first_indexed | 2024-03-07T15:18:04Z |
| format | Article |
| id | doaj.art-67fc570e68e74d35961f20e9fbb518fb |
| institution | Directory Open Access Journal |
| issn | 2092-6413 |
| language | English |
| last_indexed | 2024-03-07T15:18:04Z |
| publishDate | 2024-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-67fc570e68e74d35961f20e9fbb518fb2024-03-05T17:48:00ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132024-01-01561959910.1038/s12276-023-01148-0Pathological phenotypes of astrocytes in Alzheimer’s diseaseJunhyung Kim0Ik Dong Yoo1Jaejoon Lim2Jong-Seok Moon3Department of Integrated Biomedical Science, Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang UniversityDepartment of Nuclear Medicine, Soonchunhyang University Hospital CheonanDepartment of Neurosurgery, Bundang CHA Medical Center, CHA UniversityDepartment of Integrated Biomedical Science, Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang UniversityAbstract Astrocytes are involved in various processes in the central nervous system (CNS). As the most abundant cell type in the CNS, astrocytes play an essential role in neuronal maintenance and support, synaptic activity, neuronal metabolism, and amyloid-beta (Aβ) clearance. Alzheimer’s disease (AD) is a neurodegenerative disorder associated with cognitive and behavioral impairment. The transformation of astrocytes is involved in various neurodegenerative diseases, such as AD. Since astrocytes have functional diversity and morphological and physiological heterogeneity in the CNS, AD-related astrocytes might show various pathological phenotypes during AD. Astrocytes developing pathological phenotypes could contribute to AD progression. In this review, we provide an overview of the pathological phenotypes of astrocytes in the context of AD, highlighting recent findings in human and mouse AD.https://doi.org/10.1038/s12276-023-01148-0 |
| spellingShingle | Junhyung Kim Ik Dong Yoo Jaejoon Lim Jong-Seok Moon Pathological phenotypes of astrocytes in Alzheimer’s disease Experimental and Molecular Medicine |
| title | Pathological phenotypes of astrocytes in Alzheimer’s disease |
| title_full | Pathological phenotypes of astrocytes in Alzheimer’s disease |
| title_fullStr | Pathological phenotypes of astrocytes in Alzheimer’s disease |
| title_full_unstemmed | Pathological phenotypes of astrocytes in Alzheimer’s disease |
| title_short | Pathological phenotypes of astrocytes in Alzheimer’s disease |
| title_sort | pathological phenotypes of astrocytes in alzheimer s disease |
| url | https://doi.org/10.1038/s12276-023-01148-0 |
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