Influence of Choline-Based Ionic Liquids as Neoteric Green Solvents on Aqueous Solubility of Lamotrigine and Piroxicam Drugs
Background: New compounds called choline-based ionic liquids (ILs) that are environmentally friendly have become more attractive. In this study, some choline-based ILs (choline lactate (ChLa) and choline propionate (ChPro)) have been used to increase the aqueous solubility of lamotrigine (LTG) and p...
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2022-10-01
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| Series: | Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://ps.tbzmed.ac.ir/PDF/ps-28-616.pdf |
| _version_ | 1811237609434775552 |
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| author | Hemayat Shekaari Negar Basteholia Masumeh Mokhtarpour Mohammed Taghi Zafarani-Moattar |
| author_facet | Hemayat Shekaari Negar Basteholia Masumeh Mokhtarpour Mohammed Taghi Zafarani-Moattar |
| author_sort | Hemayat Shekaari |
| collection | DOAJ |
| description | Background: New compounds called choline-based ionic liquids (ILs) that are environmentally friendly have become more attractive. In this study, some choline-based ILs (choline lactate (ChLa) and choline propionate (ChPro)) have been used to increase the aqueous solubility of lamotrigine (LTG) and piroxicam (PXM) at T = 298.15 to 313.15 K. Methods: ILs were prepared and purified. The solubility of drugs in the aqueous ILs solutions was measured at different temperatures with shake flask method. Results: The solubility of the investigated drugs increased with increasing the weight fraction of ILs. The solubility data were correlated by e-NRTL, Wilson, Apelblat and λh (Buchowski) models. Conclusion: The aqueous solubility of drugs depends on both the weight fraction of co-solvents and the solution temperature. These two essential parameters were analyzed through some semi-empirical and activity coefficient models getting the average relative deviation percent as e-NRTL (3.09%) < Wilson (3.92%) (for full range concentration of co-solvent) and Apelblat (3.52%) < λh (Buchowski) (5.11%) (for the dilute region of co-solvent). In addition, the results show that the aqueous solubility increases with rising temperature and there are strong interactions between the drug and the ILs. |
| first_indexed | 2024-04-12T12:26:14Z |
| format | Article |
| id | doaj.art-67fde1f57247409aa5124612780a53d4 |
| institution | Directory Open Access Journal |
| issn | 2383-2886 |
| language | English |
| last_indexed | 2024-04-12T12:26:14Z |
| publishDate | 2022-10-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Pharmaceutical Sciences |
| spelling | doaj.art-67fde1f57247409aa5124612780a53d42022-12-22T03:33:09ZengTabriz University of Medical SciencesPharmaceutical Sciences2383-28862022-10-0128461662910.34172/PS.2022.12ps-34897Influence of Choline-Based Ionic Liquids as Neoteric Green Solvents on Aqueous Solubility of Lamotrigine and Piroxicam DrugsHemayat Shekaari0Negar Basteholia1Masumeh Mokhtarpour2Mohammed Taghi Zafarani-Moattar3Department of Physical Chemistry, University of Tabriz, Tabriz, Iran.Department of Physical Chemistry, University of Tabriz, Tabriz, Iran.Department of Physical Chemistry, University of Tabriz, Tabriz, Iran.Department of Physical Chemistry, University of Tabriz, Tabriz, Iran.Background: New compounds called choline-based ionic liquids (ILs) that are environmentally friendly have become more attractive. In this study, some choline-based ILs (choline lactate (ChLa) and choline propionate (ChPro)) have been used to increase the aqueous solubility of lamotrigine (LTG) and piroxicam (PXM) at T = 298.15 to 313.15 K. Methods: ILs were prepared and purified. The solubility of drugs in the aqueous ILs solutions was measured at different temperatures with shake flask method. Results: The solubility of the investigated drugs increased with increasing the weight fraction of ILs. The solubility data were correlated by e-NRTL, Wilson, Apelblat and λh (Buchowski) models. Conclusion: The aqueous solubility of drugs depends on both the weight fraction of co-solvents and the solution temperature. These two essential parameters were analyzed through some semi-empirical and activity coefficient models getting the average relative deviation percent as e-NRTL (3.09%) < Wilson (3.92%) (for full range concentration of co-solvent) and Apelblat (3.52%) < λh (Buchowski) (5.11%) (for the dilute region of co-solvent). In addition, the results show that the aqueous solubility increases with rising temperature and there are strong interactions between the drug and the ILs.https://ps.tbzmed.ac.ir/PDF/ps-28-616.pdfcholine-based ionic liquidssolubilitylamotriginepiroxicam |
| spellingShingle | Hemayat Shekaari Negar Basteholia Masumeh Mokhtarpour Mohammed Taghi Zafarani-Moattar Influence of Choline-Based Ionic Liquids as Neoteric Green Solvents on Aqueous Solubility of Lamotrigine and Piroxicam Drugs Pharmaceutical Sciences choline-based ionic liquids solubility lamotrigine piroxicam |
| title | Influence of Choline-Based Ionic Liquids as Neoteric Green Solvents on Aqueous Solubility of Lamotrigine and Piroxicam Drugs |
| title_full | Influence of Choline-Based Ionic Liquids as Neoteric Green Solvents on Aqueous Solubility of Lamotrigine and Piroxicam Drugs |
| title_fullStr | Influence of Choline-Based Ionic Liquids as Neoteric Green Solvents on Aqueous Solubility of Lamotrigine and Piroxicam Drugs |
| title_full_unstemmed | Influence of Choline-Based Ionic Liquids as Neoteric Green Solvents on Aqueous Solubility of Lamotrigine and Piroxicam Drugs |
| title_short | Influence of Choline-Based Ionic Liquids as Neoteric Green Solvents on Aqueous Solubility of Lamotrigine and Piroxicam Drugs |
| title_sort | influence of choline based ionic liquids as neoteric green solvents on aqueous solubility of lamotrigine and piroxicam drugs |
| topic | choline-based ionic liquids solubility lamotrigine piroxicam |
| url | https://ps.tbzmed.ac.ir/PDF/ps-28-616.pdf |
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