Clinical Significance of Preoperative Neutrophil – to - Lymphocyte Ratio in Renal Cell Carcinoma
ABSTRACT Introduction: We investigated the prognostic significance of the neutrophil-to-lymphocyte ratio on tumor stage and Fuhrman nuclear grade in renal cell carcinoma. Methods: The records of 432 patients with RCC who underwent radical or partial nephrectomy between 2005 and 2014 were retrospec...
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Sociedade Brasileira de Urologia
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| Series: | International Brazilian Journal of Urology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382016000400678&lng=en&tlng=en |
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| author | Alper Otunctemur Murat Dursun Huseyin Besiroglu Kutan Ozer Ozan Horsanali Emin Ozbek |
| author_facet | Alper Otunctemur Murat Dursun Huseyin Besiroglu Kutan Ozer Ozan Horsanali Emin Ozbek |
| author_sort | Alper Otunctemur |
| collection | DOAJ |
| description | ABSTRACT Introduction: We investigated the prognostic significance of the neutrophil-to-lymphocyte ratio on tumor stage and Fuhrman nuclear grade in renal cell carcinoma. Methods: The records of 432 patients with RCC who underwent radical or partial nephrectomy between 2005 and 2014 were retrospectively reviewed. Patients were classified as group lower tumor stage(T1 + T2) and higher(T3 + T4). As like tumor stage, Fuhrman nuclear grade were classified lower (G1+G2) and higher(G3+G4) too. The best NLR cut off value was 3.01. Two sample t-test or Mann–Whitney U-test used for the continuous variables and a chi-square test or Fisher's exact test used for the categorical variables. Results: Among the 432 total patients analyzed in our study, there were 275 males (63.7%) and 157 females (36.3%). Mean laboratory values were CRP 2.73 ± 1.93 mg/dL (normal less than 0.3), neutrophil count 4,23 ± 1.46/μL, lymphocyte count 1,61 ± 0,61/μL and NLR 2.64 ± 1.24. According to our data, statistically pretreatment NLR significantly correlated with CRP (p<0.0001). And tumor patologic stage (p=0.08), tumor histologic grade (p<0.001) was significantly associated with NLR. Discussion: We compared the relationship of preoperative NLR and NC parameters with RCC tumor stage and grade. And NLR were found to have statistically significant higher T stage and grade at RCC. Further studies with more patients are needed to confirm our study. |
| first_indexed | 2024-12-13T11:29:09Z |
| format | Article |
| id | doaj.art-67ff87e933c84a2e86b45b12cc39e949 |
| institution | Directory Open Access Journal |
| issn | 1677-6119 |
| language | English |
| last_indexed | 2024-12-13T11:29:09Z |
| publisher | Sociedade Brasileira de Urologia |
| record_format | Article |
| series | International Brazilian Journal of Urology |
| spelling | doaj.art-67ff87e933c84a2e86b45b12cc39e9492022-12-21T23:48:03ZengSociedade Brasileira de UrologiaInternational Brazilian Journal of Urology1677-611942467868410.1590/S1677-5538.IBJU.2015.0397S1677-55382016000400678Clinical Significance of Preoperative Neutrophil – to - Lymphocyte Ratio in Renal Cell CarcinomaAlper OtunctemurMurat DursunHuseyin BesirogluKutan OzerOzan HorsanaliEmin OzbekABSTRACT Introduction: We investigated the prognostic significance of the neutrophil-to-lymphocyte ratio on tumor stage and Fuhrman nuclear grade in renal cell carcinoma. Methods: The records of 432 patients with RCC who underwent radical or partial nephrectomy between 2005 and 2014 were retrospectively reviewed. Patients were classified as group lower tumor stage(T1 + T2) and higher(T3 + T4). As like tumor stage, Fuhrman nuclear grade were classified lower (G1+G2) and higher(G3+G4) too. The best NLR cut off value was 3.01. Two sample t-test or Mann–Whitney U-test used for the continuous variables and a chi-square test or Fisher's exact test used for the categorical variables. Results: Among the 432 total patients analyzed in our study, there were 275 males (63.7%) and 157 females (36.3%). Mean laboratory values were CRP 2.73 ± 1.93 mg/dL (normal less than 0.3), neutrophil count 4,23 ± 1.46/μL, lymphocyte count 1,61 ± 0,61/μL and NLR 2.64 ± 1.24. According to our data, statistically pretreatment NLR significantly correlated with CRP (p<0.0001). And tumor patologic stage (p=0.08), tumor histologic grade (p<0.001) was significantly associated with NLR. Discussion: We compared the relationship of preoperative NLR and NC parameters with RCC tumor stage and grade. And NLR were found to have statistically significant higher T stage and grade at RCC. Further studies with more patients are needed to confirm our study.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382016000400678&lng=en&tlng=enNeutrophilsLymphocytesCarcinomaRenal CellEpithelium |
| spellingShingle | Alper Otunctemur Murat Dursun Huseyin Besiroglu Kutan Ozer Ozan Horsanali Emin Ozbek Clinical Significance of Preoperative Neutrophil – to - Lymphocyte Ratio in Renal Cell Carcinoma International Brazilian Journal of Urology Neutrophils Lymphocytes Carcinoma Renal Cell Epithelium |
| title | Clinical Significance of Preoperative Neutrophil – to - Lymphocyte Ratio in Renal Cell Carcinoma |
| title_full | Clinical Significance of Preoperative Neutrophil – to - Lymphocyte Ratio in Renal Cell Carcinoma |
| title_fullStr | Clinical Significance of Preoperative Neutrophil – to - Lymphocyte Ratio in Renal Cell Carcinoma |
| title_full_unstemmed | Clinical Significance of Preoperative Neutrophil – to - Lymphocyte Ratio in Renal Cell Carcinoma |
| title_short | Clinical Significance of Preoperative Neutrophil – to - Lymphocyte Ratio in Renal Cell Carcinoma |
| title_sort | clinical significance of preoperative neutrophil to lymphocyte ratio in renal cell carcinoma |
| topic | Neutrophils Lymphocytes Carcinoma Renal Cell Epithelium |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382016000400678&lng=en&tlng=en |
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