A nanoemulsion-based delivery system for imatinib and in vitro anticancer efficacy
A self-nanoemulsifying drug delivery system (SNEDDS) composed of ethyl oleate, Tween 80 and polyethylene glycol 600 was prepared as a new route to improve the efficacy of imatinib. The drug-loaded SNEDDS formed nanodroplets of ethyl oleate stabilized by Tween 80 and polyethylene glycol 600 with a di...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2021-04-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100640&tlng=en |
| _version_ | 1811275458501672960 |
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| author | Maryam Karimi Khashayar Karimian Hossein Heli |
| author_facet | Maryam Karimi Khashayar Karimian Hossein Heli |
| author_sort | Maryam Karimi |
| collection | DOAJ |
| description | A self-nanoemulsifying drug delivery system (SNEDDS) composed of ethyl oleate, Tween 80 and polyethylene glycol 600 was prepared as a new route to improve the efficacy of imatinib. The drug-loaded SNEDDS formed nanodroplets of ethyl oleate stabilized by Tween 80 and polyethylene glycol 600 with a diameter of 81.0±9.5 nm. The nanoemulsion-based delivery system was stable for at least two months, with entrapment efficiency and loading capacity of 16.4±0.1 and 48.3±0.2%, respectively. Imatinib-loaded SNEDDS was evaluated for the drug release profiles, and its effectiveness against MCF-7 cell line was investigated. IC50 values for the imatinib-loaded SNEDDS and an imatinib aqueous solution were 3.1 and 6.5 µg mL-1, respectively. |
| first_indexed | 2024-04-12T23:38:11Z |
| format | Article |
| id | doaj.art-68018c2c7b4f469c975ceff79db94dee |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-04-12T23:38:11Z |
| publishDate | 2021-04-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-68018c2c7b4f469c975ceff79db94dee2022-12-22T03:12:04ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902021-04-015610.1590/s2175-97902020000118973A nanoemulsion-based delivery system for imatinib and in vitro anticancer efficacyMaryam KarimiKhashayar KarimianHossein Helihttps://orcid.org/0000-0003-1753-1193A self-nanoemulsifying drug delivery system (SNEDDS) composed of ethyl oleate, Tween 80 and polyethylene glycol 600 was prepared as a new route to improve the efficacy of imatinib. The drug-loaded SNEDDS formed nanodroplets of ethyl oleate stabilized by Tween 80 and polyethylene glycol 600 with a diameter of 81.0±9.5 nm. The nanoemulsion-based delivery system was stable for at least two months, with entrapment efficiency and loading capacity of 16.4±0.1 and 48.3±0.2%, respectively. Imatinib-loaded SNEDDS was evaluated for the drug release profiles, and its effectiveness against MCF-7 cell line was investigated. IC50 values for the imatinib-loaded SNEDDS and an imatinib aqueous solution were 3.1 and 6.5 µg mL-1, respectively.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100640&tlng=enGlivecNanoemulsionAnticancer drugBioavailabilityBreast cancer cell |
| spellingShingle | Maryam Karimi Khashayar Karimian Hossein Heli A nanoemulsion-based delivery system for imatinib and in vitro anticancer efficacy Brazilian Journal of Pharmaceutical Sciences Glivec Nanoemulsion Anticancer drug Bioavailability Breast cancer cell |
| title | A nanoemulsion-based delivery system for imatinib and in vitro anticancer efficacy |
| title_full | A nanoemulsion-based delivery system for imatinib and in vitro anticancer efficacy |
| title_fullStr | A nanoemulsion-based delivery system for imatinib and in vitro anticancer efficacy |
| title_full_unstemmed | A nanoemulsion-based delivery system for imatinib and in vitro anticancer efficacy |
| title_short | A nanoemulsion-based delivery system for imatinib and in vitro anticancer efficacy |
| title_sort | nanoemulsion based delivery system for imatinib and in vitro anticancer efficacy |
| topic | Glivec Nanoemulsion Anticancer drug Bioavailability Breast cancer cell |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100640&tlng=en |
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