Neural Correlates of Interval Timing Deficits in Schizophrenia
Previous research has shown that schizophrenia (SZ) patients exhibit impairments in interval timing. The cause of timing impairments in SZ remains unknown but may be explained by a dysfunction in the fronto-striatal circuits. Although the current literature includes extensive behavioral data on timi...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-01-01
|
| Series: | Frontiers in Human Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnhum.2019.00009/full |
| _version_ | 1819132382674944000 |
|---|---|
| author | Ariel W. Snowden Catalin V. Buhusi |
| author_facet | Ariel W. Snowden Catalin V. Buhusi |
| author_sort | Ariel W. Snowden |
| collection | DOAJ |
| description | Previous research has shown that schizophrenia (SZ) patients exhibit impairments in interval timing. The cause of timing impairments in SZ remains unknown but may be explained by a dysfunction in the fronto-striatal circuits. Although the current literature includes extensive behavioral data on timing impairments, there is limited focus on the neural correlates of timing in SZ. The neuroimaging literature included in the current review reports hypoactivation in the dorsal-lateral prefrontal cortex (DLPFC), supplementary motor area (SMA) and the basal ganglia (BG). Timing deficits and deficits in attention and working memory (WM) in SZ are likely due to a dysfunction of dopamine (DA) and gamma-aminobutyric acid (GABA) neurotransmission in the cortico-striatal-thalamo-cortical circuits, which are highly implicated in executive functioning and motor preparation. |
| first_indexed | 2024-12-22T09:30:31Z |
| format | Article |
| id | doaj.art-680364f209f5447892243dd433f90edb |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-22T09:30:31Z |
| publishDate | 2019-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-680364f209f5447892243dd433f90edb2022-12-21T18:30:58ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612019-01-011310.3389/fnhum.2019.00009428252Neural Correlates of Interval Timing Deficits in SchizophreniaAriel W. SnowdenCatalin V. BuhusiPrevious research has shown that schizophrenia (SZ) patients exhibit impairments in interval timing. The cause of timing impairments in SZ remains unknown but may be explained by a dysfunction in the fronto-striatal circuits. Although the current literature includes extensive behavioral data on timing impairments, there is limited focus on the neural correlates of timing in SZ. The neuroimaging literature included in the current review reports hypoactivation in the dorsal-lateral prefrontal cortex (DLPFC), supplementary motor area (SMA) and the basal ganglia (BG). Timing deficits and deficits in attention and working memory (WM) in SZ are likely due to a dysfunction of dopamine (DA) and gamma-aminobutyric acid (GABA) neurotransmission in the cortico-striatal-thalamo-cortical circuits, which are highly implicated in executive functioning and motor preparation.https://www.frontiersin.org/article/10.3389/fnhum.2019.00009/fullschizophreniainterval timingattentioncognitive dysfunctionworking memoryneural correlates |
| spellingShingle | Ariel W. Snowden Catalin V. Buhusi Neural Correlates of Interval Timing Deficits in Schizophrenia Frontiers in Human Neuroscience schizophrenia interval timing attention cognitive dysfunction working memory neural correlates |
| title | Neural Correlates of Interval Timing Deficits in Schizophrenia |
| title_full | Neural Correlates of Interval Timing Deficits in Schizophrenia |
| title_fullStr | Neural Correlates of Interval Timing Deficits in Schizophrenia |
| title_full_unstemmed | Neural Correlates of Interval Timing Deficits in Schizophrenia |
| title_short | Neural Correlates of Interval Timing Deficits in Schizophrenia |
| title_sort | neural correlates of interval timing deficits in schizophrenia |
| topic | schizophrenia interval timing attention cognitive dysfunction working memory neural correlates |
| url | https://www.frontiersin.org/article/10.3389/fnhum.2019.00009/full |
| work_keys_str_mv | AT arielwsnowden neuralcorrelatesofintervaltimingdeficitsinschizophrenia AT catalinvbuhusi neuralcorrelatesofintervaltimingdeficitsinschizophrenia |