Overview of Checkpoint Inhibitors Mechanism of Action: Role of Immune-Related Adverse Events and Their Treatment on Progression of Underlying Cancer

Overview of Checkpoint Inhibitors Mechanism of Action: Role of Immune-Related Adverse Events and Their Treatment on Progression of Underlying Cancer

In recent years, immunotherapy-based regimens have been included into the treatment's algorithm of several cancer types. Programmed death-1 (PD-1) and cytotoxic T lymphocyte antigen-4 (CTLA-4) interact with their ligands found on the surface of antigen presenting cells (APC) or tumor cells (PD-...

Full description

Bibliographic Details
Main Authors: Patricia Iranzo, Ana Callejo, Juan David Assaf, Gaspar Molina, Daniel Esteban Lopez, David Garcia-Illescas, Nuria Pardo, Alejandro Navarro, Alex Martinez-Marti, Susana Cedres, Caterina Carbonell, Joan Frigola, Ramon Amat, Enriqueta Felip
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Medicine
Subjects:
immune checkpoint inhibitors (ICIs)
immune-related adverse events (irAEs)
corticosteroids
efficacy
multidisciplinary management
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.875974/full

Similar Items

Similar Items