A study to determine if estrogen (E) is needed to induce de novo progesterone (P) receptors on gamma/delta t cells as evidenced by determining the degree of rise of progesterone induced blocking factor (PIBF) following P exposure in males
Purpose: To determine if exposure to progesterone (P) alone without prior estrogen (E) exposure can cause a rise in serum progesterone induced blocking factor (PIBF). Materials and Methods: Male volunteers received IM progesterone 100 mg for seven days. Baseline and day seven levels of serum P and P...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2020-06-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/47/3/10.31083/j.ceog.2020.03.5078 |
| Summary: | Purpose: To determine if exposure to progesterone (P) alone without prior estrogen (E) exposure can cause a rise in serum progesterone induced blocking factor (PIBF). Materials and Methods: Male volunteers received IM progesterone 100 mg for seven days. Baseline and day seven levels of serum P and PIBF were taken. PIBF was measured using a non-commercial newly developed ELISA assay. Results: A significant rise in PIBF was found in male volunteers on day seven. Conclusions: The precipitous rise in serum PIBF in males despite a short exposure to progesterone shows that a person does not need E to induce PIBF secretion by gamma/delta T cells. The possibility still exists pending future studies that E may improve PIBF secretion. |
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| ISSN: | 0390-6663 |