A study to determine if estrogen (E) is needed to induce de novo progesterone (P) receptors on gamma/delta t cells as evidenced by determining the degree of rise of progesterone induced blocking factor (PIBF) following P exposure in males
Purpose: To determine if exposure to progesterone (P) alone without prior estrogen (E) exposure can cause a rise in serum progesterone induced blocking factor (PIBF). Materials and Methods: Male volunteers received IM progesterone 100 mg for seven days. Baseline and day seven levels of serum P and P...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2020-06-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/47/3/10.31083/j.ceog.2020.03.5078 |
| _version_ | 1828553610877730816 |
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| author | J.H. Check A. DiAntonio D.L. Check M.P. Dougherty G. Diantonio |
| author_facet | J.H. Check A. DiAntonio D.L. Check M.P. Dougherty G. Diantonio |
| author_sort | J.H. Check |
| collection | DOAJ |
| description | Purpose: To determine if exposure to progesterone (P) alone without prior estrogen (E) exposure can cause a rise in serum progesterone induced blocking factor (PIBF). Materials and Methods: Male volunteers received IM progesterone 100 mg for seven days. Baseline and day seven levels of serum P and PIBF were taken. PIBF was measured using a non-commercial newly developed ELISA assay. Results: A significant rise in PIBF was found in male volunteers on day seven. Conclusions: The precipitous rise in serum PIBF in males despite a short exposure to progesterone shows that a person does not need E to induce PIBF secretion by gamma/delta T cells. The possibility still exists pending future studies that E may improve PIBF secretion. |
| first_indexed | 2024-12-12T05:20:18Z |
| format | Article |
| id | doaj.art-680b52e6b8af475788e65bc2831d59e4 |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-12-12T05:20:18Z |
| publishDate | 2020-06-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-680b52e6b8af475788e65bc2831d59e42022-12-22T00:36:37ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632020-06-0147341942010.31083/j.ceog.2020.03.5078S0390-6663(20)00278-XA study to determine if estrogen (E) is needed to induce de novo progesterone (P) receptors on gamma/delta t cells as evidenced by determining the degree of rise of progesterone induced blocking factor (PIBF) following P exposure in malesJ.H. Check0A. DiAntonio1D.L. Check2M.P. Dougherty3G. Diantonio4Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Cooper Medical School of Rowan University, Camden, New Jersey, USACooper Institute for Reproductive Hormonal Disorders, P.C., Marlton, New Jersey, USACooper Institute for Reproductive Hormonal Disorders, P.C., Marlton, New Jersey, USADepartment Of Obstetrics, Gynecology And Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, Robert Wood Hohnson Univeristy Hospital, New Brunswick, NJ, USACooper Institute for Reproductive Hormonal Disorders, P.C., Marlton, New Jersey, USAPurpose: To determine if exposure to progesterone (P) alone without prior estrogen (E) exposure can cause a rise in serum progesterone induced blocking factor (PIBF). Materials and Methods: Male volunteers received IM progesterone 100 mg for seven days. Baseline and day seven levels of serum P and PIBF were taken. PIBF was measured using a non-commercial newly developed ELISA assay. Results: A significant rise in PIBF was found in male volunteers on day seven. Conclusions: The precipitous rise in serum PIBF in males despite a short exposure to progesterone shows that a person does not need E to induce PIBF secretion by gamma/delta T cells. The possibility still exists pending future studies that E may improve PIBF secretion.https://www.imrpress.com/journal/CEOG/47/3/10.31083/j.ceog.2020.03.5078immunomodulatory proteinsprogesteroneprogesterone induced blocking factor (pibf)malesestrogen |
| spellingShingle | J.H. Check A. DiAntonio D.L. Check M.P. Dougherty G. Diantonio A study to determine if estrogen (E) is needed to induce de novo progesterone (P) receptors on gamma/delta t cells as evidenced by determining the degree of rise of progesterone induced blocking factor (PIBF) following P exposure in males Clinical and Experimental Obstetrics & Gynecology immunomodulatory proteins progesterone progesterone induced blocking factor (pibf) males estrogen |
| title | A study to determine if estrogen (E) is needed to induce de novo progesterone (P) receptors on gamma/delta t cells as evidenced by determining the degree of rise of progesterone induced blocking factor (PIBF) following P exposure in males |
| title_full | A study to determine if estrogen (E) is needed to induce de novo progesterone (P) receptors on gamma/delta t cells as evidenced by determining the degree of rise of progesterone induced blocking factor (PIBF) following P exposure in males |
| title_fullStr | A study to determine if estrogen (E) is needed to induce de novo progesterone (P) receptors on gamma/delta t cells as evidenced by determining the degree of rise of progesterone induced blocking factor (PIBF) following P exposure in males |
| title_full_unstemmed | A study to determine if estrogen (E) is needed to induce de novo progesterone (P) receptors on gamma/delta t cells as evidenced by determining the degree of rise of progesterone induced blocking factor (PIBF) following P exposure in males |
| title_short | A study to determine if estrogen (E) is needed to induce de novo progesterone (P) receptors on gamma/delta t cells as evidenced by determining the degree of rise of progesterone induced blocking factor (PIBF) following P exposure in males |
| title_sort | study to determine if estrogen e is needed to induce de novo progesterone p receptors on gamma delta t cells as evidenced by determining the degree of rise of progesterone induced blocking factor pibf following p exposure in males |
| topic | immunomodulatory proteins progesterone progesterone induced blocking factor (pibf) males estrogen |
| url | https://www.imrpress.com/journal/CEOG/47/3/10.31083/j.ceog.2020.03.5078 |
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