Nanotheranostics for Image-Guided Cancer Treatment
Image-guided nanotheranostics have the potential to represent a new paradigm in the treatment of cancer. Recent developments in modern imaging and nanoparticle design offer an answer to many of the issues associated with conventional chemotherapy, including their indiscriminate side effects and susc...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/14/5/917 |
| _version_ | 1797496785759895552 |
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| author | Isabel S. Dennahy Zheng Han William M. MacCuaig Hunter M. Chalfant Anna Condacse Jordan M. Hagood Juan C. Claros-Sorto Wajeeha Razaq Jennifer Holter-Chakrabarty Ronald Squires Barish H. Edil Ajay Jain Lacey R. McNally |
| author_facet | Isabel S. Dennahy Zheng Han William M. MacCuaig Hunter M. Chalfant Anna Condacse Jordan M. Hagood Juan C. Claros-Sorto Wajeeha Razaq Jennifer Holter-Chakrabarty Ronald Squires Barish H. Edil Ajay Jain Lacey R. McNally |
| author_sort | Isabel S. Dennahy |
| collection | DOAJ |
| description | Image-guided nanotheranostics have the potential to represent a new paradigm in the treatment of cancer. Recent developments in modern imaging and nanoparticle design offer an answer to many of the issues associated with conventional chemotherapy, including their indiscriminate side effects and susceptibility to drug resistance. Imaging is one of the tools best poised to enable tailoring of cancer therapies. The field of image-guided nanotheranostics has the potential to harness the precision of modern imaging techniques and use this to direct, dictate, and follow site-specific drug delivery, all of which can be used to further tailor cancer therapies on both the individual and population level. The use of image-guided drug delivery has exploded in preclinical and clinical trials although the clinical translation is incipient. This review will focus on traditional mechanisms of targeted drug delivery in cancer, including the use of molecular targeting, as well as the foundations of designing nanotheranostics, with a focus on current clinical applications of nanotheranostics in cancer. A variety of specially engineered and targeted drug carriers, along with strategies of labeling nanoparticles to endow detectability in different imaging modalities will be reviewed. It will also introduce newer concepts of image-guided drug delivery, which may circumvent many of the issues seen with other techniques. Finally, we will review the current barriers to clinical translation of image-guided nanotheranostics and how these may be overcome. |
| first_indexed | 2024-03-10T03:08:32Z |
| format | Article |
| id | doaj.art-680bc71e75f747e3ac6194eed8187bb7 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T03:08:32Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-680bc71e75f747e3ac6194eed8187bb72023-11-23T12:36:27ZengMDPI AGPharmaceutics1999-49232022-04-0114591710.3390/pharmaceutics14050917Nanotheranostics for Image-Guided Cancer TreatmentIsabel S. Dennahy0Zheng Han1William M. MacCuaig2Hunter M. Chalfant3Anna Condacse4Jordan M. Hagood5Juan C. Claros-Sorto6Wajeeha Razaq7Jennifer Holter-Chakrabarty8Ronald Squires9Barish H. Edil10Ajay Jain11Lacey R. McNally12Department of Surgery, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USADepartment of Surgery, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USADepartment of Bioengineering, University of Oklahoma, Norman, OK 73019, USADepartment of Surgery, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USADepartment of Surgery, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USADepartment of Surgery, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USADepartment of Surgery, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USADepartment of Internal Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USADepartment of Internal Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USADepartment of Surgery, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USADepartment of Surgery, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USADepartment of Surgery, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USADepartment of Surgery, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USAImage-guided nanotheranostics have the potential to represent a new paradigm in the treatment of cancer. Recent developments in modern imaging and nanoparticle design offer an answer to many of the issues associated with conventional chemotherapy, including their indiscriminate side effects and susceptibility to drug resistance. Imaging is one of the tools best poised to enable tailoring of cancer therapies. The field of image-guided nanotheranostics has the potential to harness the precision of modern imaging techniques and use this to direct, dictate, and follow site-specific drug delivery, all of which can be used to further tailor cancer therapies on both the individual and population level. The use of image-guided drug delivery has exploded in preclinical and clinical trials although the clinical translation is incipient. This review will focus on traditional mechanisms of targeted drug delivery in cancer, including the use of molecular targeting, as well as the foundations of designing nanotheranostics, with a focus on current clinical applications of nanotheranostics in cancer. A variety of specially engineered and targeted drug carriers, along with strategies of labeling nanoparticles to endow detectability in different imaging modalities will be reviewed. It will also introduce newer concepts of image-guided drug delivery, which may circumvent many of the issues seen with other techniques. Finally, we will review the current barriers to clinical translation of image-guided nanotheranostics and how these may be overcome.https://www.mdpi.com/1999-4923/14/5/917targeted drug deliveryantibody–drug conjugatesnanotheranosticsimage-guided therapynanoparticlesdrug carriers |
| spellingShingle | Isabel S. Dennahy Zheng Han William M. MacCuaig Hunter M. Chalfant Anna Condacse Jordan M. Hagood Juan C. Claros-Sorto Wajeeha Razaq Jennifer Holter-Chakrabarty Ronald Squires Barish H. Edil Ajay Jain Lacey R. McNally Nanotheranostics for Image-Guided Cancer Treatment Pharmaceutics targeted drug delivery antibody–drug conjugates nanotheranostics image-guided therapy nanoparticles drug carriers |
| title | Nanotheranostics for Image-Guided Cancer Treatment |
| title_full | Nanotheranostics for Image-Guided Cancer Treatment |
| title_fullStr | Nanotheranostics for Image-Guided Cancer Treatment |
| title_full_unstemmed | Nanotheranostics for Image-Guided Cancer Treatment |
| title_short | Nanotheranostics for Image-Guided Cancer Treatment |
| title_sort | nanotheranostics for image guided cancer treatment |
| topic | targeted drug delivery antibody–drug conjugates nanotheranostics image-guided therapy nanoparticles drug carriers |
| url | https://www.mdpi.com/1999-4923/14/5/917 |
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