Statin-related Lichenoid Dermatosis: An Uncommon Adverse Reaction to a Common Treatment
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are generally safe and well-tolerated drugs that are extensively used for the primary and secondary prevention of atherosclerotic cardiovascular events. Muscle and liver adverse reactions are the best recognized, while cutaneous si...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
SMC MEDIA SRL
2018-02-01
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| Series: | European Journal of Case Reports in Internal Medicine |
| Subjects: | |
| Online Access: | https://www.ejcrim.com/index.php/EJCRIM/article/view/844 |
| _version_ | 1819236533931081728 |
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| author | Zsófia Vesza Catarina Pires Pedro Marques da Silva |
| author_facet | Zsófia Vesza Catarina Pires Pedro Marques da Silva |
| author_sort | Zsófia Vesza |
| collection | DOAJ |
| description | 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are generally safe and well-tolerated drugs that are extensively used for the primary and secondary prevention of atherosclerotic cardiovascular events. Muscle and liver adverse reactions are the best recognized, while cutaneous side effects are exceedingly rare. We present the case of a 65-year-old woman with severe hypercholesterolemia, who developed generalized erythematous cutaneous lesions with pruritus, resembling lichen planus, months after starting treatment with simvastatin. The symptoms disappeared on withdrawal of simvastatin and reappeared within 3 months upon rechallenge with rosuvastatin. In addition to describing a rare adverse effect of statins, the authors also discuss the nutraceutical approach to the management of a statin-intolerant patient. |
| first_indexed | 2024-12-23T13:05:57Z |
| format | Article |
| id | doaj.art-680d0104d1854e2b906425322f387b29 |
| institution | Directory Open Access Journal |
| issn | 2284-2594 |
| language | English |
| last_indexed | 2024-12-23T13:05:57Z |
| publishDate | 2018-02-01 |
| publisher | SMC MEDIA SRL |
| record_format | Article |
| series | European Journal of Case Reports in Internal Medicine |
| spelling | doaj.art-680d0104d1854e2b906425322f387b292022-12-21T17:45:53ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942018-02-015510.12890/2018_000844844Statin-related Lichenoid Dermatosis: An Uncommon Adverse Reaction to a Common TreatmentZsófia Vesza0Catarina Pires1Pedro Marques da Silva2Hypertension and Dyslipidemia Outpatient Clinic, Medicine 4, Santa Marta's Hospital, CHLC, Lisbon, PortugalHypertension and Dyslipidemia Outpatient Clinic, Medicine 4, Santa Marta's Hospital, CHLC, Lisbon, PortugalHypertension and Dyslipidemia Outpatient Clinic, Medicine 4, Santa Marta's Hospital, CHLC, Lisbon, Portugal3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are generally safe and well-tolerated drugs that are extensively used for the primary and secondary prevention of atherosclerotic cardiovascular events. Muscle and liver adverse reactions are the best recognized, while cutaneous side effects are exceedingly rare. We present the case of a 65-year-old woman with severe hypercholesterolemia, who developed generalized erythematous cutaneous lesions with pruritus, resembling lichen planus, months after starting treatment with simvastatin. The symptoms disappeared on withdrawal of simvastatin and reappeared within 3 months upon rechallenge with rosuvastatin. In addition to describing a rare adverse effect of statins, the authors also discuss the nutraceutical approach to the management of a statin-intolerant patient.https://www.ejcrim.com/index.php/EJCRIM/article/view/844Lichenoid drug eruptiondyslipidemiastatinsnutraceuticalsred yeast rice |
| spellingShingle | Zsófia Vesza Catarina Pires Pedro Marques da Silva Statin-related Lichenoid Dermatosis: An Uncommon Adverse Reaction to a Common Treatment European Journal of Case Reports in Internal Medicine Lichenoid drug eruption dyslipidemia statins nutraceuticals red yeast rice |
| title | Statin-related Lichenoid Dermatosis: An Uncommon Adverse Reaction to a Common Treatment |
| title_full | Statin-related Lichenoid Dermatosis: An Uncommon Adverse Reaction to a Common Treatment |
| title_fullStr | Statin-related Lichenoid Dermatosis: An Uncommon Adverse Reaction to a Common Treatment |
| title_full_unstemmed | Statin-related Lichenoid Dermatosis: An Uncommon Adverse Reaction to a Common Treatment |
| title_short | Statin-related Lichenoid Dermatosis: An Uncommon Adverse Reaction to a Common Treatment |
| title_sort | statin related lichenoid dermatosis an uncommon adverse reaction to a common treatment |
| topic | Lichenoid drug eruption dyslipidemia statins nutraceuticals red yeast rice |
| url | https://www.ejcrim.com/index.php/EJCRIM/article/view/844 |
| work_keys_str_mv | AT zsofiavesza statinrelatedlichenoiddermatosisanuncommonadversereactiontoacommontreatment AT catarinapires statinrelatedlichenoiddermatosisanuncommonadversereactiontoacommontreatment AT pedromarquesdasilva statinrelatedlichenoiddermatosisanuncommonadversereactiontoacommontreatment |