Secular Trends of Clinical Characteristics and Survival of Hepatocellular Carcinoma in Taiwan from 2011 to 2019
Hepatocellular carcinoma (HCC) is a major cause of cancer death in Taiwan, and in the past 30–40 years, Taiwan has been committed to its prevention and treatment. We aimed to investigate the secular trends of characteristics and the survival of HCC in recent decades after making increased efforts. B...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/1/126 |
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| author | Kwong-Ming Kee Chien-Hung Chen Jui-Ting Hu Yi-Hsiang Huang Tsang-En Wang Gar-Yang Chau Kuo-Hsin Chen Yao-Li Chen Chih-Che Lin Chien-Fu Hung Shiu-Feng Huang Tsang-Wu Liu Hsiu-Ying Ku Bing-Shen Huang Yi-Pin Wang Hui-Ping Tseng Chun-Ju Chiang Sheng-Nan Lu |
| author_facet | Kwong-Ming Kee Chien-Hung Chen Jui-Ting Hu Yi-Hsiang Huang Tsang-En Wang Gar-Yang Chau Kuo-Hsin Chen Yao-Li Chen Chih-Che Lin Chien-Fu Hung Shiu-Feng Huang Tsang-Wu Liu Hsiu-Ying Ku Bing-Shen Huang Yi-Pin Wang Hui-Ping Tseng Chun-Ju Chiang Sheng-Nan Lu |
| author_sort | Kwong-Ming Kee |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is a major cause of cancer death in Taiwan, and in the past 30–40 years, Taiwan has been committed to its prevention and treatment. We aimed to investigate the secular trends of characteristics and the survival of HCC in recent decades after making increased efforts. Between 2011 and 2019, a total of 73,817 cases were enrolled from the TCR database. The overall male-to-female ratio was 7/3. The overall, male and female mean ages increased from 63.8 to 66.1 years, 62.0 to 64.3 years and 68.3 to 70.4 years, respectively. After dividing by viral etiologies and gender, the mean age showed increasing trends in all subgroups. The proportions of HBV-HCC, HCV-HCC, HBV+HCV-HCC and Non-HBV+non-HCV-HCC were 48.3%, 25.2%, 5.3% and 21.3% in males, compared with 25.5%, 48.6%, 5.3% and 20.5% in females, respectively. The 5-year survival rates of BCLC stages 0, A, B, C and D were 70%, 58%, 34%, 11% and 4%, respectively. The proportion of BCLC stage 0 increased from 6.2% to 11.3%. Multivariate analysis showed that being female, older age, diagnostic year, BCLC stages, hospital level, body mass index, smoking, alcohol consumption, AFP, Child–Pugh classification and HBV/HCV status were independent predictors for survival. In recent decades, the overall survival of HCC in Taiwan has been improving and might be partly associated with increased BCLC 0 and Child–Pugh A patients, while with the consequent age of patients increasing over time. The proportion of viral-related HCC is decreasing, while nonviral-related HCC is increasing. |
| first_indexed | 2024-03-09T11:02:11Z |
| format | Article |
| id | doaj.art-680dc7a220944016bfb1d3e8762b29cd |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T11:02:11Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-680dc7a220944016bfb1d3e8762b29cd2023-12-01T01:10:41ZengMDPI AGViruses1999-49152022-12-0115112610.3390/v15010126Secular Trends of Clinical Characteristics and Survival of Hepatocellular Carcinoma in Taiwan from 2011 to 2019Kwong-Ming Kee0Chien-Hung Chen1Jui-Ting Hu2Yi-Hsiang Huang3Tsang-En Wang4Gar-Yang Chau5Kuo-Hsin Chen6Yao-Li Chen7Chih-Che Lin8Chien-Fu Hung9Shiu-Feng Huang10Tsang-Wu Liu11Hsiu-Ying Ku12Bing-Shen Huang13Yi-Pin Wang14Hui-Ping Tseng15Chun-Ju Chiang16Sheng-Nan Lu17Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan City 83302, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Douliu City 64041, TaiwanLiver Unit, Cathay General Hospital, Taipei City 10630, TaiwanDivision of Gastroenterology and Hepatology, Taipei Veterans General Hospital, Taipei City 11217, TaiwanDivision of Gastroenterology, Department of Internal Medicine, MacKay Memorial Hospital, Taipei City 10449, TaiwanDivision of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei City 11217, TaiwanDivision of General Surgery, Department of Surgery, Far Eastern Memorial Hospital, New Taipei City 22060, TaiwanDepartment of Surgery, Changhua Christian Hospital, Changhua 50046, TaiwanDepartment of Surgery, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung City 83301, TaiwanDepartment of Radiology, New Taipei Municipal Tucheng Hospital, New Taipei City 23652, TaiwanNational Institute of Cancer Research, National Health Research Institutes, Miaoli 35053, TaiwanNational Institute of Cancer Research, National Health Research Institutes, Miaoli 35053, TaiwanNational Institute of Cancer Research, National Health Research Institutes, Miaoli 35053, TaiwanDepartment of Radiation Oncology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan City 33305, TaiwanCancer Administration and Coordination Center, National Taiwan University Hospital, Taipei City 10002, TaiwanCancer Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City 83301, TaiwanGraduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei 10002, TaiwanGraduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan City 83302, TaiwanHepatocellular carcinoma (HCC) is a major cause of cancer death in Taiwan, and in the past 30–40 years, Taiwan has been committed to its prevention and treatment. We aimed to investigate the secular trends of characteristics and the survival of HCC in recent decades after making increased efforts. Between 2011 and 2019, a total of 73,817 cases were enrolled from the TCR database. The overall male-to-female ratio was 7/3. The overall, male and female mean ages increased from 63.8 to 66.1 years, 62.0 to 64.3 years and 68.3 to 70.4 years, respectively. After dividing by viral etiologies and gender, the mean age showed increasing trends in all subgroups. The proportions of HBV-HCC, HCV-HCC, HBV+HCV-HCC and Non-HBV+non-HCV-HCC were 48.3%, 25.2%, 5.3% and 21.3% in males, compared with 25.5%, 48.6%, 5.3% and 20.5% in females, respectively. The 5-year survival rates of BCLC stages 0, A, B, C and D were 70%, 58%, 34%, 11% and 4%, respectively. The proportion of BCLC stage 0 increased from 6.2% to 11.3%. Multivariate analysis showed that being female, older age, diagnostic year, BCLC stages, hospital level, body mass index, smoking, alcohol consumption, AFP, Child–Pugh classification and HBV/HCV status were independent predictors for survival. In recent decades, the overall survival of HCC in Taiwan has been improving and might be partly associated with increased BCLC 0 and Child–Pugh A patients, while with the consequent age of patients increasing over time. The proportion of viral-related HCC is decreasing, while nonviral-related HCC is increasing.https://www.mdpi.com/1999-4915/15/1/126hepatitis C virushepatitis B virushepatocellular carcinomagenderagenon-B and non-C viral hepatitis |
| spellingShingle | Kwong-Ming Kee Chien-Hung Chen Jui-Ting Hu Yi-Hsiang Huang Tsang-En Wang Gar-Yang Chau Kuo-Hsin Chen Yao-Li Chen Chih-Che Lin Chien-Fu Hung Shiu-Feng Huang Tsang-Wu Liu Hsiu-Ying Ku Bing-Shen Huang Yi-Pin Wang Hui-Ping Tseng Chun-Ju Chiang Sheng-Nan Lu Secular Trends of Clinical Characteristics and Survival of Hepatocellular Carcinoma in Taiwan from 2011 to 2019 Viruses hepatitis C virus hepatitis B virus hepatocellular carcinoma gender age non-B and non-C viral hepatitis |
| title | Secular Trends of Clinical Characteristics and Survival of Hepatocellular Carcinoma in Taiwan from 2011 to 2019 |
| title_full | Secular Trends of Clinical Characteristics and Survival of Hepatocellular Carcinoma in Taiwan from 2011 to 2019 |
| title_fullStr | Secular Trends of Clinical Characteristics and Survival of Hepatocellular Carcinoma in Taiwan from 2011 to 2019 |
| title_full_unstemmed | Secular Trends of Clinical Characteristics and Survival of Hepatocellular Carcinoma in Taiwan from 2011 to 2019 |
| title_short | Secular Trends of Clinical Characteristics and Survival of Hepatocellular Carcinoma in Taiwan from 2011 to 2019 |
| title_sort | secular trends of clinical characteristics and survival of hepatocellular carcinoma in taiwan from 2011 to 2019 |
| topic | hepatitis C virus hepatitis B virus hepatocellular carcinoma gender age non-B and non-C viral hepatitis |
| url | https://www.mdpi.com/1999-4915/15/1/126 |
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