The influence of Gleason score ≤ 6 histology on the outcome of high-risk localized prostate cancer after modern radiotherapy

The influence of Gleason score ≤ 6 histology on the outcome of high-risk localized prostate cancer after modern radiotherapy

Abstract We aimed to retrospectively review outcomes in patients with high-risk prostate cancer and a Gleason score ≤ 6 following modern radiotherapy. We analyzed the outcomes of 1374 patients who had undergone modern radiotherapy, comprising a high-risk low grade [HRLG] group (Gleason score ≤ 6; n ...

Full description

Bibliographic Details
Main Authors:	Hideya Yamazaki, Gen Suzuki, Koji Masui, Norihiro Aibe, Takuya Kimoto, Kei Yamada, Koji Okihara, Fumiya Hongo, Masayoshi Okumi, Takumi Shiraishi, Atsuko Fujihara, Ken Yoshida, Satoaki Nakamura, Takashi Kato, Yasutoshi Hashimoto, Haruumi Okabe
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-04-01
Series:	Scientific Reports
Subjects:	Prostate cancer High-dose-rate brachytherapy Low-dose-rate brachytherapy Intensity modulated radiotherapy Stereotactic body radiotherapy Gleason score
Online Access:	https://doi.org/10.1038/s41598-024-55457-z

Similar Items

Role of Brachytherapy Boost in Clinically Localized Intermediate and High-Risk Prostate Cancer: Lack of Benefit in Patients with Very High-Risk Factors T3b–4 and/or Gleason 9–10
by: Hideya Yamazaki, et al.
Published: (2022-06-01)

Novel Prognostic Index of High-Risk Prostate Cancer Using Simple Summation of Very High-Risk Factors
by: Hideya Yamazaki, et al.
Published: (2021-07-01)

High-Dose-Rate Brachytherapy Monotherapy versus Image-Guided Intensity-Modulated Radiotherapy with Helical Tomotherapy for Patients with Localized Prostate Cancer
by: Hideya Yamazaki, et al.
Published: (2018-09-01)

Radiotherapy for Clinically Localized T3b or T4 Very-High-Risk Prostate Cancer-Role of Dose Escalation Using High-Dose-Rate Brachytherapy Boost or High Dose Intensity Modulated Radiotherapy
by: Hideya Yamazaki, et al.
Published: (2021-04-01)

Comparison of two high dose rate brachytherapy regimes
by: Gaurav Jaswal, et al.
Published: (2023-01-01)

Adjuvant high dose rate brachytherapy for soft tissue sarcomas: initial experience report
by: Robert Whitfield, et al.
Published: (2011-03-01)

Ultra-High Prostate-Specific Antigen Level: A Potential Very-High-Risk Factor for Localized High-Risk Prostate Cancer
by: Hideya Yamazaki, et al.
Published: (2023-11-01)

Pulsed dose rate brachytherapy as the boost in combination with external beam irradiation in base of tongue cancer. Long-term results from a uniform clinical series
by: Bengt Johansson, et al.
Published: (2011-03-01)

Small bowel perforation caused by applicator implantation in high-dose-rate interstitial brachytherapy for recurrent pelvic tumor: a case report
by: Koji Masui, et al.
Published: (2020-03-01)

Brachytherapy boost in anal canal cancer – A GEC ESTRO PDR task force meta-analysis
by: Pierre Annede, et al.
Published: (2023-03-01)

Re-irradiation with interstitial brachytherapy in uterine cancer patients with vaginal recurrence after post-operative pelvic irradiation
by: Keiko Nemoto Murofushi, et al.
Published: (2022-02-01)

Results from chemoradiotherapy for squamous cell cervical cancer with or without intracavitary brachytherapy
by: Diogo Delgado, et al.
Published: (2019-09-01)

Practical brachytherapy solutions to an age-old quandary
by: N. Thiruthaneeswaran, et al.
Published: (2020-12-01)

Comparative Study between conventional EBRT alone and EBRT followed by intraluminal brachytherapy in local advanced cancer esophagus
by: Kapil Kumar Soni, et al.
Published: (2023-01-01)

Challenge and Outcome for the Prostate Squamous Cell Carcinoma Which Developed 8 Years after Low-Dose-Rate Brachytherapy Approached by a Combined Multimodal Treatment with High-Dose-Rate Interstitial Brachytherapy, External Beam Radiation Therapy, and Chemotherapy
by: Toru Matsugasumi, et al.
Published: (2021-06-01)

Salvage high-dose-rate interventional radiotherapy (brachytherapy) for locally relapsed prostate cancer after radical prostatectomy and subsequent external irradiation
by: Tamer Soror, et al.
Published: (2023-06-01)

Efficacy and tolerance of high-dose-rate brachytherapy boost after external radiotherapy in the treatment of squamous cell carcinoma of the anal canal
by: Emilien Bertin, et al.
Published: (2018-12-01)

A modified technique for fabrication of custom-made afterload brachytherapy appliance
by: Sumeet Jain, et al.
Published: (2019-01-01)

Outcomes with multi-disciplinary management of central lung tumors with CT-guided percutaneous high dose rate brachyablation
by: Stephanie M. Yoon, et al.
Published: (2021-06-01)

Feasibility and clinical implementation of MRI-guided surface brachytherapy
by: Michael J. Lavelle, et al.
Published: (2024-02-01)

Salvage High-Dose-Rate Interventional Radiotherapy (Brachytherapy) Combined with Surgery for Regionally Relapsed Head and Neck Cancers
by: Tamer Soror, et al.
Published: (2023-09-01)

Pulsed Dose Rate Brachytherapy of Lip Carcinoma: Clinical Outcome and Quality of Life Analysis
by: Radouane El Ayachy, et al.
Published: (2021-03-01)

Five-year quality of life in patients with high-risk localized prostate cancer treated with external beam radiotherapy alone versus external beam radiotherapy with high-dose-rate brachytherapy boost: a prospective multicenter study
by: Evelyn Martínez, et al.
Published: (2021-02-01)

Indian Brachytherapy Society Guidelines for radiotherapeutic management of cervical cancer with special emphasis on high-dose-rate brachytherapy
by: Umesh Mahantshetty, et al.
Published: (2019-08-01)

Clinical outcome after high dose rate intracavitary brachytherapy with traditional point ‘A’ dose prescription in locally advanced carcinoma of uterine cervix: dosimetric analysis from the perspective of computed tomography imaging-based 3-dimensional treatment planning
by: Suman Dhabal, et al.
Published: (2024-01-01)

Clinical Efficacy and Openness to New Challenges of Low Dose Rate Brachytherapy for Prostate Cancer
by: Manabu Kato, et al.
Published: (2023-11-01)

Outcomes and dose—volume parameters for computed tomography-based brachytherapy planning for vaginal recurrence of uterine cancer primarily treated with surgery
by: Keiko Nemoto Murofushi, et al.
Published: (2021-06-01)

Evaluation of doses to pelvic lymph node regions from image-guided high-dose-rate interstitial brachytherapy for carcinoma of the uterine cervix
by: Ajeet Gandhi, et al.
Published: (2023-08-01)

Single-fraction high-dose-rate brachytherapy: a scoping review on outcomes and toxicities for all disease sites
by: Mehdi Kazemi, et al.
Published: (2022-11-01)

Complete response in a patient with gynecological hidradenocarcinoma treated with exclusive external beam radiotherapy and brachytherapy: a case report
by: Flavio Giannelli, et al.
Published: (2017-12-01)

Fibre-optic endoscope-guided three-dimensional high-dose-rate interstitial brachytherapy for residual nasopharyngeal carcinoma after conventional external beam radiotherapy
by: Xiaoni Zhang, et al.
Published: (2019-06-01)

High-dose rate surface mold brachytherapy in a case of squamous cell carcinoma of lower eyelid: A case report from a rural cancer center of Maharashtra
by: Vandana Shailendra Jain, et al.
Published: (2019-01-01)

High-Dose Rate Salvage Interstitial Brachytherapy: A Case-Based Guide to the Treatment of Therapeutically Challenging Recurrent Vulvar Cancer
by: Kelly Eileen Hughes, et al.
Published: (2017-09-01)

Clinical advantage and outcomes of computed tomography‐based transvaginal hybrid brachytherapy performed only by sedation without general or saddle block anesthesia
by: Noriyuki Okonogi, et al.
Published: (2022-11-01)

Ultrahypofractionated Radiotherapy versus Conventional to Moderate Hypofractionated Radiotherapy for Clinically Localized Prostate Cancer
by: Hideya Yamazaki, et al.
Published: (2021-12-01)

Does brachytherapy boost improve survival outcomes in Gleason Grade Group 5 patients treated with external beam radiotherapy and androgen deprivation therapy? A systematic review and meta-analysis
by: Terence Tang, et al.
Published: (2023-01-01)

Outcomes of salvage high-dose-rate brachytherapy with or without external beam radiotherapy for isolated vaginal recurrence of endometrial cancer
by: Shuhei Sekii, et al.
Published: (2017-05-01)

A Fifteen Years Audit of Endometrial Cancer Referred for Adjuvant Treatment to a Tertiary Care Hospital in Northern India
by: Pramod Kumar Gupta, et al.
Published: (2023-07-01)

A Comparative Study of Soft Tissue Sarcomas of the Extremities: Brachytherapy versus Radiotherapy
by: Arvin Najafi, et al.
Published: (2022-04-01)

Can brachytherapy be properly considered in the clinical practice? Trilogy project: The vision of the AIRO (Italian Association of Radiotherapy and Clinical Oncology) Interventional Radiotherapy study group
by: Luca Tagliaferri, et al.
Published: (2020-02-01)