Reported willingness to participate in a hypothetical HIV vaccine trial and its translation to actual participation among healthy adults-Experience from Kenya.
OBJECTIVE:To evaluate initial reported willingness to participate in a hypothetical HIV vaccine clinical trial and actual participation of volunteers in a longitudinal observational study. METHODS:We recruited HIV negative male and female volunteers aged 18-45 years into a longitudinal observational...
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| Format: | Article |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6214541?pdf=render |
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| author | Delvin Kwamboka Nyasani Gaudensia Nzembi Mutua Rose Miroyo Sajabi Jane Wairimu Ng'ang'a John Ndungu Gachie Amos Macharia Maina Laura Lunani Lusike Aggrey Omu Anzala Matthew A Price Gloria Omosa Manyonyi |
| author_facet | Delvin Kwamboka Nyasani Gaudensia Nzembi Mutua Rose Miroyo Sajabi Jane Wairimu Ng'ang'a John Ndungu Gachie Amos Macharia Maina Laura Lunani Lusike Aggrey Omu Anzala Matthew A Price Gloria Omosa Manyonyi |
| author_sort | Delvin Kwamboka Nyasani |
| collection | DOAJ |
| description | OBJECTIVE:To evaluate initial reported willingness to participate in a hypothetical HIV vaccine clinical trial and actual participation of volunteers in a longitudinal observational study. METHODS:We recruited HIV negative male and female volunteers aged 18-45 years into a longitudinal observational study at KAVI-ICR Kangemi in Kenya, to serve as a pool from which to draw participants into a phase I HIV vaccine clinical trial. A structured questionnaire was used to collect information regarding willingness to join a HIV vaccine clinical trial in the future. Study follow-up visits were every 6 months. RESULTS:A total of 105 participants were screened and 100 (M46:F54) were enrolled into the observational study. Ninety- four per cent of those enrolled expressed willingness to participate in a future HIV vaccine trial. Altruism and desire to learn the body's response to the vaccine were the most motivating factors at 40% and 25% respectively. At the onset of a 40-person phase I HIV vaccine trial, 86 observational study participants who had previously expressed willingness to participate were contacted but only 26 (30%) came for information. All 26 consented to participate and after screening for eligibility, 24 were eligible. Of the 24, 15 were enrolled. These numbers were not adequate; hence the vaccine trial employed other recruitment methods to meet the deficit. CONCLUSION:Observational "pools" of cohorts may not provide adequate number of participants into vaccine clinical trials even if they report willingness; therefore supplementary recruitment methods such as direct community recruitment, passive approach, and snowballing need to be in place. |
| first_indexed | 2024-04-13T01:34:19Z |
| format | Article |
| id | doaj.art-681042f6ed5248c1a9d1e34e0bb883e0 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T01:34:19Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-681042f6ed5248c1a9d1e34e0bb883e02022-12-22T03:08:25ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-011311e020665610.1371/journal.pone.0206656Reported willingness to participate in a hypothetical HIV vaccine trial and its translation to actual participation among healthy adults-Experience from Kenya.Delvin Kwamboka NyasaniGaudensia Nzembi MutuaRose Miroyo SajabiJane Wairimu Ng'ang'aJohn Ndungu GachieAmos Macharia MainaLaura Lunani LusikeAggrey Omu AnzalaMatthew A PriceGloria Omosa ManyonyiOBJECTIVE:To evaluate initial reported willingness to participate in a hypothetical HIV vaccine clinical trial and actual participation of volunteers in a longitudinal observational study. METHODS:We recruited HIV negative male and female volunteers aged 18-45 years into a longitudinal observational study at KAVI-ICR Kangemi in Kenya, to serve as a pool from which to draw participants into a phase I HIV vaccine clinical trial. A structured questionnaire was used to collect information regarding willingness to join a HIV vaccine clinical trial in the future. Study follow-up visits were every 6 months. RESULTS:A total of 105 participants were screened and 100 (M46:F54) were enrolled into the observational study. Ninety- four per cent of those enrolled expressed willingness to participate in a future HIV vaccine trial. Altruism and desire to learn the body's response to the vaccine were the most motivating factors at 40% and 25% respectively. At the onset of a 40-person phase I HIV vaccine trial, 86 observational study participants who had previously expressed willingness to participate were contacted but only 26 (30%) came for information. All 26 consented to participate and after screening for eligibility, 24 were eligible. Of the 24, 15 were enrolled. These numbers were not adequate; hence the vaccine trial employed other recruitment methods to meet the deficit. CONCLUSION:Observational "pools" of cohorts may not provide adequate number of participants into vaccine clinical trials even if they report willingness; therefore supplementary recruitment methods such as direct community recruitment, passive approach, and snowballing need to be in place.http://europepmc.org/articles/PMC6214541?pdf=render |
| spellingShingle | Delvin Kwamboka Nyasani Gaudensia Nzembi Mutua Rose Miroyo Sajabi Jane Wairimu Ng'ang'a John Ndungu Gachie Amos Macharia Maina Laura Lunani Lusike Aggrey Omu Anzala Matthew A Price Gloria Omosa Manyonyi Reported willingness to participate in a hypothetical HIV vaccine trial and its translation to actual participation among healthy adults-Experience from Kenya. PLoS ONE |
| title | Reported willingness to participate in a hypothetical HIV vaccine trial and its translation to actual participation among healthy adults-Experience from Kenya. |
| title_full | Reported willingness to participate in a hypothetical HIV vaccine trial and its translation to actual participation among healthy adults-Experience from Kenya. |
| title_fullStr | Reported willingness to participate in a hypothetical HIV vaccine trial and its translation to actual participation among healthy adults-Experience from Kenya. |
| title_full_unstemmed | Reported willingness to participate in a hypothetical HIV vaccine trial and its translation to actual participation among healthy adults-Experience from Kenya. |
| title_short | Reported willingness to participate in a hypothetical HIV vaccine trial and its translation to actual participation among healthy adults-Experience from Kenya. |
| title_sort | reported willingness to participate in a hypothetical hiv vaccine trial and its translation to actual participation among healthy adults experience from kenya |
| url | http://europepmc.org/articles/PMC6214541?pdf=render |
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