Modern approaches in the treatment of Lennox–gastaut syndrome (a review of literature)

Lennox–Gastaut syndrome (LGS) is a childhood epileptic encephalopathy characterized by frequent polymorphic seizures (including tonic axial seizures), pronounced cognitive impairment, typical changes in the electroencephalogram and drug resistance. Frequency of LGS accounts for approximately 4–10 %...

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Main Authors: К. Yu. Мukhin, О. A. Pylaeva
Format: Article
Language:Russian
Published: ABV-press 2018-11-01
Series:Русский журнал детской неврологии
Subjects:
Online Access:https://rjdn.abvpress.ru/jour/article/view/269
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author К. Yu. Мukhin
О. A. Pylaeva
author_facet К. Yu. Мukhin
О. A. Pylaeva
author_sort К. Yu. Мukhin
collection DOAJ
description Lennox–Gastaut syndrome (LGS) is a childhood epileptic encephalopathy characterized by frequent polymorphic seizures (including tonic axial seizures), pronounced cognitive impairment, typical changes in the electroencephalogram and drug resistance. Frequency of LGS accounts for approximately 4–10 % of all childhood epilepsy. The difficulties in the diagnosis and treatment of LGS are associated with the presence of various seizures that are frequently resistant to multiple antiepileptic drugs as well as with the disease evolution with age. This review covers the main principles of LGS therapy, analyzes the most common antiepileptic drugs used in LGS, and describes clinical trials evaluating the efficacy and tolerability of antiepileptic drugs in LGS. The article contains a detailed algorithm for the treatment of LGS, based on international guidelines and expert opinions.
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spelling doaj.art-6811b9c07c284d7081cb759c03c2a0ae2023-03-13T09:30:12ZrusABV-pressРусский журнал детской неврологии2073-88032412-91782018-11-01132345710.17650/2073-8803-2018-13-2-34-57186Modern approaches in the treatment of Lennox–gastaut syndrome (a review of literature)К. Yu. Мukhin0О. A. Pylaeva1ООО «Институт детской неврологии и эпилепсии им. Святителя Луки»ООО «Институт детской неврологии и эпилепсии им. Святителя Луки»Lennox–Gastaut syndrome (LGS) is a childhood epileptic encephalopathy characterized by frequent polymorphic seizures (including tonic axial seizures), pronounced cognitive impairment, typical changes in the electroencephalogram and drug resistance. Frequency of LGS accounts for approximately 4–10 % of all childhood epilepsy. The difficulties in the diagnosis and treatment of LGS are associated with the presence of various seizures that are frequently resistant to multiple antiepileptic drugs as well as with the disease evolution with age. This review covers the main principles of LGS therapy, analyzes the most common antiepileptic drugs used in LGS, and describes clinical trials evaluating the efficacy and tolerability of antiepileptic drugs in LGS. The article contains a detailed algorithm for the treatment of LGS, based on international guidelines and expert opinions.https://rjdn.abvpress.ru/jour/article/view/269эпилепсиярезистентные формы эпилепсиисиндром леннокса–гастоэпилептический приступтонический эпилептический приступантиэпилептический препаратэффективностьпереносимость
spellingShingle К. Yu. Мukhin
О. A. Pylaeva
Modern approaches in the treatment of Lennox–gastaut syndrome (a review of literature)
Русский журнал детской неврологии
эпилепсия
резистентные формы эпилепсии
синдром леннокса–гасто
эпилептический приступ
тонический эпилептический приступ
антиэпилептический препарат
эффективность
переносимость
title Modern approaches in the treatment of Lennox–gastaut syndrome (a review of literature)
title_full Modern approaches in the treatment of Lennox–gastaut syndrome (a review of literature)
title_fullStr Modern approaches in the treatment of Lennox–gastaut syndrome (a review of literature)
title_full_unstemmed Modern approaches in the treatment of Lennox–gastaut syndrome (a review of literature)
title_short Modern approaches in the treatment of Lennox–gastaut syndrome (a review of literature)
title_sort modern approaches in the treatment of lennox gastaut syndrome a review of literature
topic эпилепсия
резистентные формы эпилепсии
синдром леннокса–гасто
эпилептический приступ
тонический эпилептический приступ
антиэпилептический препарат
эффективность
переносимость
url https://rjdn.abvpress.ru/jour/article/view/269
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