Does psychiatric molecular genetics need to account for the birth cohort effect?
Major psychiatric disorders including alcohol use disorder are considered multigenic and the smallness of effects of individual genes may be attributed to either complex biological mechanisms or geneenvironment interactions. The latter explanation is highlighted by the relatively fast changes in sec...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation
2019-12-01
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| Series: | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
| Subjects: | |
| Online Access: | https://www.bekhterevreview.com/jour/article/view/296 |
| _version_ | 1797694444235915264 |
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| author | J. Harro K. Laas M. Vaht D. Eensoo T. Kurrikoff K. Sakala E. Kiive T. Veidebaum |
| author_facet | J. Harro K. Laas M. Vaht D. Eensoo T. Kurrikoff K. Sakala E. Kiive T. Veidebaum |
| author_sort | J. Harro |
| collection | DOAJ |
| description | Major psychiatric disorders including alcohol use disorder are considered multigenic and the smallness of effects of individual genes may be attributed to either complex biological mechanisms or geneenvironment interactions. The latter explanation is highlighted by the relatively fast changes in secular trends and in cohort effects on alcohol use disorder. Interactions of candidate gene variants with birth cohort have been found in the Estonian Children Personality Behaviour and Health Study, a longitudinal investigation from 1998 with a sample highly representative of birth cohorts within a region. Such interactions regarding initiation of alcohol use or alcohol use disorder have been revealed for e.g., 5-HTTLPR, VMAT1, OXR and NRG1, and suggest that rapid alterations in the socioeconomic environment promote changes in the genetic vulnerability to environmental risks factors such as alcohol. |
| first_indexed | 2024-03-12T02:58:03Z |
| format | Article |
| id | doaj.art-6811de3d38e247f5bb00896653c15024 |
| institution | Directory Open Access Journal |
| issn | 2313-7053 2713-055X |
| language | Russian |
| last_indexed | 2024-03-12T02:58:03Z |
| publishDate | 2019-12-01 |
| publisher | Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation |
| record_format | Article |
| series | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
| spelling | doaj.art-6811de3d38e247f5bb00896653c150242023-09-03T15:08:42ZrusFederal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian FederationОбозрение психиатрии и медицинской психологии имени В.М. Бехтерева2313-70532713-055X2019-12-0104-1283010.31363/2313-7053-2019-4-1-28-30275Does psychiatric molecular genetics need to account for the birth cohort effect?J. Harro0K. Laas1M. Vaht2D. Eensoo3T. Kurrikoff4K. Sakala5E. Kiive6T. Veidebaum7Division of Neuropsychopharmacology, Department of Psychology, University of TartuDivision of Neuropsychopharmacology, Department of Psychology, University of TartuDivision of Neuropsychopharmacology, Department of Psychology, University of TartuDepartment of Family Medicine and Public Health, University of TartuDivision of Sociology, Department of Social Studies, University of TartuDepartment of Family Medicine and Public Health, University of Tartu; National Institute for Health DevelopmentDivision of Special Education, Department of Education, University of TartuDivision of Special Education, Department of Education, University of TartuMajor psychiatric disorders including alcohol use disorder are considered multigenic and the smallness of effects of individual genes may be attributed to either complex biological mechanisms or geneenvironment interactions. The latter explanation is highlighted by the relatively fast changes in secular trends and in cohort effects on alcohol use disorder. Interactions of candidate gene variants with birth cohort have been found in the Estonian Children Personality Behaviour and Health Study, a longitudinal investigation from 1998 with a sample highly representative of birth cohorts within a region. Such interactions regarding initiation of alcohol use or alcohol use disorder have been revealed for e.g., 5-HTTLPR, VMAT1, OXR and NRG1, and suggest that rapid alterations in the socioeconomic environment promote changes in the genetic vulnerability to environmental risks factors such as alcohol.https://www.bekhterevreview.com/jour/article/view/296alcohol use. candidate genesgene-environment interactionscohort effectssex |
| spellingShingle | J. Harro K. Laas M. Vaht D. Eensoo T. Kurrikoff K. Sakala E. Kiive T. Veidebaum Does psychiatric molecular genetics need to account for the birth cohort effect? Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева alcohol use. candidate genes gene-environment interactions cohort effects sex |
| title | Does psychiatric molecular genetics need to account for the birth cohort effect? |
| title_full | Does psychiatric molecular genetics need to account for the birth cohort effect? |
| title_fullStr | Does psychiatric molecular genetics need to account for the birth cohort effect? |
| title_full_unstemmed | Does psychiatric molecular genetics need to account for the birth cohort effect? |
| title_short | Does psychiatric molecular genetics need to account for the birth cohort effect? |
| title_sort | does psychiatric molecular genetics need to account for the birth cohort effect |
| topic | alcohol use. candidate genes gene-environment interactions cohort effects sex |
| url | https://www.bekhterevreview.com/jour/article/view/296 |
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