New Prostate Cancer Targets for Diagnosis, Imaging, and Therapy: Focus on Prostate-Specific Membrane Antigen
The rising incidence rate of the cancer in the prostate gland has increased the demand for improved diagnostic, imaging, and therapeutic approaches. Prostate-specific membrane antigen (PSMA), with folate hydrolase and carboxypeptidase and, internalization activities, is highly expressed in the epith...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2018-12-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2018.00653/full |
| _version_ | 1817981952274202624 |
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| author | Alessia Cimadamore Monica Cheng Matteo Santoni Antonio Lopez-Beltran Nicola Battelli Francesco Massari Andrea B. Galosi Marina Scarpelli Rodolfo Montironi |
| author_facet | Alessia Cimadamore Monica Cheng Matteo Santoni Antonio Lopez-Beltran Nicola Battelli Francesco Massari Andrea B. Galosi Marina Scarpelli Rodolfo Montironi |
| author_sort | Alessia Cimadamore |
| collection | DOAJ |
| description | The rising incidence rate of the cancer in the prostate gland has increased the demand for improved diagnostic, imaging, and therapeutic approaches. Prostate-specific membrane antigen (PSMA), with folate hydrolase and carboxypeptidase and, internalization activities, is highly expressed in the epithelial cells of the prostate gland and is strongly upregulated in prostatic adenocarcinoma, with elevated expression correlating with, metastasis, progression, and androgen independence. Recently, PSMA has been an active target of investigation by several approaches, including the successful utilization of small molecule inhibitors, RNA aptamer conjugates, PSMA-based immunotherapy, and PSMA-targeted prodrug therapy. Future investigations of PSMA in prostate cancer (PCa) should focus in particular on its intracellular activities and functions. The objective of this contribution is to review the current role of PSMA as a marker for PCa diagnosis, imaging, and therapy. |
| first_indexed | 2024-04-13T23:13:05Z |
| format | Article |
| id | doaj.art-6813ffff51f94fa0a1f95395092546c6 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T23:13:05Z |
| publishDate | 2018-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-6813ffff51f94fa0a1f95395092546c62022-12-22T02:25:29ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2018-12-01810.3389/fonc.2018.00653411831New Prostate Cancer Targets for Diagnosis, Imaging, and Therapy: Focus on Prostate-Specific Membrane AntigenAlessia Cimadamore0Monica Cheng1Matteo Santoni2Antonio Lopez-Beltran3Nicola Battelli4Francesco Massari5Andrea B. Galosi6Marina Scarpelli7Rodolfo Montironi8Section of Pathological Anatomy, School of Medicine, United Hospitals, Polytechnic University of the Marche Region, Ancona, ItalyDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United StatesOncology Unit, Macerata Hospital, Macerata, ItalyDepartment of Pathology and Surgery, Faculty of Medicine, Cordoba, SpainOncology Unit, Macerata Hospital, Macerata, ItalyDivision of Oncology, S. Orsola-Malpighi Hospital, Bologna, ItalyInstitute of Urology, School of Medicine, United Hospitals, Marche Polytechnic University, Ancona, ItalySection of Pathological Anatomy, School of Medicine, United Hospitals, Polytechnic University of the Marche Region, Ancona, ItalySection of Pathological Anatomy, School of Medicine, United Hospitals, Polytechnic University of the Marche Region, Ancona, ItalyThe rising incidence rate of the cancer in the prostate gland has increased the demand for improved diagnostic, imaging, and therapeutic approaches. Prostate-specific membrane antigen (PSMA), with folate hydrolase and carboxypeptidase and, internalization activities, is highly expressed in the epithelial cells of the prostate gland and is strongly upregulated in prostatic adenocarcinoma, with elevated expression correlating with, metastasis, progression, and androgen independence. Recently, PSMA has been an active target of investigation by several approaches, including the successful utilization of small molecule inhibitors, RNA aptamer conjugates, PSMA-based immunotherapy, and PSMA-targeted prodrug therapy. Future investigations of PSMA in prostate cancer (PCa) should focus in particular on its intracellular activities and functions. The objective of this contribution is to review the current role of PSMA as a marker for PCa diagnosis, imaging, and therapy.https://www.frontiersin.org/article/10.3389/fonc.2018.00653/fullprostate cancerprostate-specific membrane antigenPSMAsmall molecule inhibitorsRNA aptamer conjugatesPSMA-based immunotherapy |
| spellingShingle | Alessia Cimadamore Monica Cheng Matteo Santoni Antonio Lopez-Beltran Nicola Battelli Francesco Massari Andrea B. Galosi Marina Scarpelli Rodolfo Montironi New Prostate Cancer Targets for Diagnosis, Imaging, and Therapy: Focus on Prostate-Specific Membrane Antigen Frontiers in Oncology prostate cancer prostate-specific membrane antigen PSMA small molecule inhibitors RNA aptamer conjugates PSMA-based immunotherapy |
| title | New Prostate Cancer Targets for Diagnosis, Imaging, and Therapy: Focus on Prostate-Specific Membrane Antigen |
| title_full | New Prostate Cancer Targets for Diagnosis, Imaging, and Therapy: Focus on Prostate-Specific Membrane Antigen |
| title_fullStr | New Prostate Cancer Targets for Diagnosis, Imaging, and Therapy: Focus on Prostate-Specific Membrane Antigen |
| title_full_unstemmed | New Prostate Cancer Targets for Diagnosis, Imaging, and Therapy: Focus on Prostate-Specific Membrane Antigen |
| title_short | New Prostate Cancer Targets for Diagnosis, Imaging, and Therapy: Focus on Prostate-Specific Membrane Antigen |
| title_sort | new prostate cancer targets for diagnosis imaging and therapy focus on prostate specific membrane antigen |
| topic | prostate cancer prostate-specific membrane antigen PSMA small molecule inhibitors RNA aptamer conjugates PSMA-based immunotherapy |
| url | https://www.frontiersin.org/article/10.3389/fonc.2018.00653/full |
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