Anti-toxicity test of Peperomia pellucida steeping on liver function in diabetic-induced rat
Liver is important for both defense mechanism and protein synthesis in the human body. This study examined the anti-toxicity of Peperomia pellucida on liver function of diabetic-induced rats. It was an experimental study using pre- and post-test control group design. Rats were categorized into five...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Jenderal Soedirman University
2020-07-01
|
| Series: | Molekul |
| Online Access: | https://ojs.jmolekul.com/ojs/index.php/jm/article/view/586 |
| _version_ | 1818138207886245888 |
|---|---|
| author | Saryono Saryono Hernayanti Hernayanti Atikah Proverawati |
| author_facet | Saryono Saryono Hernayanti Hernayanti Atikah Proverawati |
| author_sort | Saryono Saryono |
| collection | DOAJ |
| description | Liver is important for both defense mechanism and protein synthesis in the human body. This study examined the anti-toxicity of Peperomia pellucida on liver function of diabetic-induced rats. It was an experimental study using pre- and post-test control group design. Rats were categorized into five groups, i.e., groups of healthy control (A), negative control (B), and treatment (C-E) with dosages of 150, 300, and 600 mg/kg of P. pellucida, respectively. Each group comprises of 5 rats. The TNF-a, IL-12, and GSH were measured before and after a 14 days administration of P. pellucida. The data were analyzed by using one-way ANOVA test followed by Duncan's post hoc test with a significance level of 5%. The result showed that P. pellucida steeping can improve liver cell damage, which was shown from the parameters of liver function, inflammation, and antioxidants. The mean of TNF-a and IL-12 levels decreased while the total protein, albumin, and GSH levels increased significantly after administration of P. pellucida steeping. Our study concluded that P. pellucida steeping might reduce TNF-a and IL-12 levels, and increased GSH level in diabetic-induced rat. A 300 mg/kg was the most effective dosage to reduce IL-12 and increase GSH. |
| first_indexed | 2024-12-11T10:08:32Z |
| format | Article |
| id | doaj.art-68150b64a3ea4b2c89c67070f4f51620 |
| institution | Directory Open Access Journal |
| issn | 1907-9761 2503-0310 |
| language | English |
| last_indexed | 2024-12-11T10:08:32Z |
| publishDate | 2020-07-01 |
| publisher | Jenderal Soedirman University |
| record_format | Article |
| series | Molekul |
| spelling | doaj.art-68150b64a3ea4b2c89c67070f4f516202022-12-22T01:11:51ZengJenderal Soedirman UniversityMolekul1907-97612503-03102020-07-011529710410.20884/1.jm.2020.15.2.586300Anti-toxicity test of Peperomia pellucida steeping on liver function in diabetic-induced ratSaryono Saryono0Hernayanti Hernayanti1Atikah Proverawati2University of Jenderal SoedirmanUniversity of Jenderal SoedirmanUniversity of Jenderal SoedirmanLiver is important for both defense mechanism and protein synthesis in the human body. This study examined the anti-toxicity of Peperomia pellucida on liver function of diabetic-induced rats. It was an experimental study using pre- and post-test control group design. Rats were categorized into five groups, i.e., groups of healthy control (A), negative control (B), and treatment (C-E) with dosages of 150, 300, and 600 mg/kg of P. pellucida, respectively. Each group comprises of 5 rats. The TNF-a, IL-12, and GSH were measured before and after a 14 days administration of P. pellucida. The data were analyzed by using one-way ANOVA test followed by Duncan's post hoc test with a significance level of 5%. The result showed that P. pellucida steeping can improve liver cell damage, which was shown from the parameters of liver function, inflammation, and antioxidants. The mean of TNF-a and IL-12 levels decreased while the total protein, albumin, and GSH levels increased significantly after administration of P. pellucida steeping. Our study concluded that P. pellucida steeping might reduce TNF-a and IL-12 levels, and increased GSH level in diabetic-induced rat. A 300 mg/kg was the most effective dosage to reduce IL-12 and increase GSH.https://ojs.jmolekul.com/ojs/index.php/jm/article/view/586 |
| spellingShingle | Saryono Saryono Hernayanti Hernayanti Atikah Proverawati Anti-toxicity test of Peperomia pellucida steeping on liver function in diabetic-induced rat Molekul |
| title | Anti-toxicity test of Peperomia pellucida steeping on liver function in diabetic-induced rat |
| title_full | Anti-toxicity test of Peperomia pellucida steeping on liver function in diabetic-induced rat |
| title_fullStr | Anti-toxicity test of Peperomia pellucida steeping on liver function in diabetic-induced rat |
| title_full_unstemmed | Anti-toxicity test of Peperomia pellucida steeping on liver function in diabetic-induced rat |
| title_short | Anti-toxicity test of Peperomia pellucida steeping on liver function in diabetic-induced rat |
| title_sort | anti toxicity test of peperomia pellucida steeping on liver function in diabetic induced rat |
| url | https://ojs.jmolekul.com/ojs/index.php/jm/article/view/586 |
| work_keys_str_mv | AT saryonosaryono antitoxicitytestofpeperomiapellucidasteepingonliverfunctionindiabeticinducedrat AT hernayantihernayanti antitoxicitytestofpeperomiapellucidasteepingonliverfunctionindiabeticinducedrat AT atikahproverawati antitoxicitytestofpeperomiapellucidasteepingonliverfunctionindiabeticinducedrat |