Clinicopathological analysis of prognostic factors in colorectal carcinoma
BACKGROUND Prediction of prognosis is vital for therapy options in patients with colorectal carcinoma (CRC). We aimed to identify some prognostic factors that could ensure a more adequate prediction of CRC patients’ outcome. MATERIALS AND METHODS We performed a study on a group of 253 CRC pat...
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Format: | Article |
Language: | English |
Published: |
Victor Babes University of Medicine and Pharmacy Timisoara
2016-12-01
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Series: | Research and Clinical Medicine |
Subjects: | |
Online Access: | http://www.resclinmed.eu/public/data_files/articles/28/article_28.pdf |
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author | Aura Jurescu Adelina Gheju Remus Cornea Anca Muresan Codruta Lazureanu Sorina Taban Alis Dema |
author_facet | Aura Jurescu Adelina Gheju Remus Cornea Anca Muresan Codruta Lazureanu Sorina Taban Alis Dema |
author_sort | Aura Jurescu |
collection | DOAJ |
description | BACKGROUND
Prediction of prognosis is vital for therapy options
in patients with colorectal carcinoma (CRC). We aimed to
identify some prognostic factors that could ensure a more
adequate prediction of CRC patients’ outcome.
MATERIALS AND METHODS
We performed a study on a group of 253 CRC
patients in the County Hospital ofTimișoara. The
following variable parameters: age, gender, histological
type, depth of tumor invasion (pT), histological grade
(G), lymph node metastasis (LNM), lympho-vascular
invasion (LVI) were analyzed using Fisher’s exact test.
RESULTS
The incidence of CRC increased with age.
Gender distribution was evidenced as follows: 159 (63%)
were male patients and 94 (37%) were female patients.
234 (92%) cases were conventional adenocarcinomas
(ADK nM), 19 (8%) were mucinous adenocarcinomas
(ADK M). 1% of cases were pT1 stage, 9% pT2, 58%
pT3 and 32% pT4 stage. 5% of the tumors were G1, 95%
G2, G3, G4. In pT1&pT2 stages only 4% presented LVI,
while in pT3&pT4 LVI was significantly higher, 42% of
the examined cases. Only two cases from pT1&pT2
tumors showed LNM vs. 55% (127 cases) of pT3&pT4
stages.
CONCLUSIONS
Tumor stage remains the most important
prognostic predictor of clinical outcome for these
patients. Pathologic assessment of various
clinicopathological factors plays n essential role in patient
management.
Graphical abstract: Infiltrative aspects of colorectal
carcinoma
REFERENCES
1. Corman ML. Carcinoma of the Colon. In:
Corman ML, editors. Colon and Rectal Surgery.
5-th edition. Philadelphia: Lippincott Williams
nad Wilkins. 2005. p. 767-920.
2. Bresalier R. Malignant neoplasms of the large
intestine. In: Feldman M, Friedman LS, Sleisenger
MH (Editors). Gastrointestinal and Liver Disease
(Pathology, Diagnosis, Management).
Philadelphia, London,New York: Saunders. 2002.
p. 2215-2263.
3. Schneider N, Langner C. Prognostic stratification
of colorectal cancer patients: current perspectives.
Cancer Management and Research. 2014;6:291-
300. |
first_indexed | 2024-04-12T12:13:32Z |
format | Article |
id | doaj.art-68152a5f721b41f6a5d9c1a4594ca717 |
institution | Directory Open Access Journal |
issn | 2360-1124 2537-5393 |
language | English |
last_indexed | 2024-04-12T12:13:32Z |
publishDate | 2016-12-01 |
publisher | Victor Babes University of Medicine and Pharmacy Timisoara |
record_format | Article |
series | Research and Clinical Medicine |
spelling | doaj.art-68152a5f721b41f6a5d9c1a4594ca7172022-12-22T03:33:31ZengVictor Babes University of Medicine and Pharmacy TimisoaraResearch and Clinical Medicine2360-11242537-53932016-12-01ISuppl.177Clinicopathological analysis of prognostic factors in colorectal carcinomaAura Jurescu 0 Adelina Gheju 1Remus Cornea 2Anca Muresan 3Codruta Lazureanu 4Sorina Taban 5Alis Dema6Victor Babeș University of Medicine and Pharmacy Timișoara , Pathology Department, Timișoara, Romania 2. The Pius Brînzeu Emergency County Hospital Timișoara, RomaniaVictor Babeș University of Medicine and Pharmacy Timișoara , Pathology Department, Timișoara, Romania 2. The Pius Brînzeu Emergency County Hospital Timișoara, RomaniaVictor Babeș University of Medicine and Pharmacy Timișoara , Pathology Department, Timișoara, Romania 2. The Pius Brînzeu Emergency County Hospital Timișoara, RomaniaVictor Babeș University of Medicine and Pharmacy Timișoara , Pathology Department, Timișoara, Romania 2. The Pius Brînzeu Emergency County Hospital Timișoara, RomaniaVictor Babeș University of Medicine and Pharmacy Timișoara , Pathology Department, Timișoara, Romania 2. The Pius Brînzeu Emergency County Hospital Timișoara, RomaniaVictor Babeș University of Medicine and Pharmacy Timișoara , Pathology Department, Timișoara, Romania 2. The Pius Brînzeu Emergency County Hospital Timișoara, RomaniaVictor Babeș University of Medicine and Pharmacy Timișoara , Pathology Department, Timișoara, Romania 2. The Pius Brînzeu Emergency County Hospital Timișoara, RomaniaBACKGROUND Prediction of prognosis is vital for therapy options in patients with colorectal carcinoma (CRC). We aimed to identify some prognostic factors that could ensure a more adequate prediction of CRC patients’ outcome. MATERIALS AND METHODS We performed a study on a group of 253 CRC patients in the County Hospital ofTimișoara. The following variable parameters: age, gender, histological type, depth of tumor invasion (pT), histological grade (G), lymph node metastasis (LNM), lympho-vascular invasion (LVI) were analyzed using Fisher’s exact test. RESULTS The incidence of CRC increased with age. Gender distribution was evidenced as follows: 159 (63%) were male patients and 94 (37%) were female patients. 234 (92%) cases were conventional adenocarcinomas (ADK nM), 19 (8%) were mucinous adenocarcinomas (ADK M). 1% of cases were pT1 stage, 9% pT2, 58% pT3 and 32% pT4 stage. 5% of the tumors were G1, 95% G2, G3, G4. In pT1&pT2 stages only 4% presented LVI, while in pT3&pT4 LVI was significantly higher, 42% of the examined cases. Only two cases from pT1&pT2 tumors showed LNM vs. 55% (127 cases) of pT3&pT4 stages. CONCLUSIONS Tumor stage remains the most important prognostic predictor of clinical outcome for these patients. Pathologic assessment of various clinicopathological factors plays n essential role in patient management. Graphical abstract: Infiltrative aspects of colorectal carcinoma REFERENCES 1. Corman ML. Carcinoma of the Colon. In: Corman ML, editors. Colon and Rectal Surgery. 5-th edition. Philadelphia: Lippincott Williams nad Wilkins. 2005. p. 767-920. 2. Bresalier R. Malignant neoplasms of the large intestine. In: Feldman M, Friedman LS, Sleisenger MH (Editors). Gastrointestinal and Liver Disease (Pathology, Diagnosis, Management). Philadelphia, London,New York: Saunders. 2002. p. 2215-2263. 3. Schneider N, Langner C. Prognostic stratification of colorectal cancer patients: current perspectives. Cancer Management and Research. 2014;6:291- 300.http://www.resclinmed.eu/public/data_files/articles/28/article_28.pdfcolorectal carcinomaprognostic factorstumor stageoutcome. |
spellingShingle | Aura Jurescu Adelina Gheju Remus Cornea Anca Muresan Codruta Lazureanu Sorina Taban Alis Dema Clinicopathological analysis of prognostic factors in colorectal carcinoma Research and Clinical Medicine colorectal carcinoma prognostic factors tumor stage outcome. |
title | Clinicopathological analysis of prognostic factors in colorectal carcinoma |
title_full | Clinicopathological analysis of prognostic factors in colorectal carcinoma |
title_fullStr | Clinicopathological analysis of prognostic factors in colorectal carcinoma |
title_full_unstemmed | Clinicopathological analysis of prognostic factors in colorectal carcinoma |
title_short | Clinicopathological analysis of prognostic factors in colorectal carcinoma |
title_sort | clinicopathological analysis of prognostic factors in colorectal carcinoma |
topic | colorectal carcinoma prognostic factors tumor stage outcome. |
url | http://www.resclinmed.eu/public/data_files/articles/28/article_28.pdf |
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