Difficulty of Differential Diagnosis: Granulomatous Diseases of Nasal Cavity and Paranasal Sinuses
Infectious diseases are important causes of granulomatous diseases of the nasal cavity and paranasal sinuses. The most frequent bacterial agents responsible for granulomatous infections are Mycobacterium species (spp.) and Actinomyces spp. In the case of fungal pathogens, Aspergillus spp. are the mo...
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| Format: | Article |
| Language: | English |
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Galenos Yayincilik
2013-09-01
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| Series: | Turkish Archives of Otorhinolaryngology |
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http://turkarchotolaryngol.net/archives/archive-detail/article-preview/difficulty-of-differential-diagnosis-granulomatous/43422
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| _version_ | 1797918898900697088 |
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| author | Onur Ergün Cavid Cabbarzade Rıza Önder Günaydın Serdar Özer Nilda Süslü |
| author_facet | Onur Ergün Cavid Cabbarzade Rıza Önder Günaydın Serdar Özer Nilda Süslü |
| author_sort | Onur Ergün |
| collection | DOAJ |
| description | Infectious diseases are important causes of granulomatous diseases of the nasal cavity and paranasal sinuses. The most frequent bacterial agents responsible for granulomatous infections are Mycobacterium species (spp.) and Actinomyces spp. In the case of fungal pathogens, Aspergillus spp. are the most frequent. Mucor spp., Cryptococcus spp. and Histoplasma spp. are the other fungal microorganisms causing granulomatous reactions. In this case report, a patient suffering from a chronic nasal cavity lesion for 4 years with a recently developed premaxillary skin lesion is presented. Despite many biopsies having been performed and pathological studies conducted, a definitive diagnosis and an effective treatment could not be achieved. Finally, Aspergillus growth was observed in the fungal growth media when the material of the last skin biopsy was sent to microbiology as well as pathology. The patient was diagnosed as “chronic nasal fungal infection” and voricanozole treatment was initiated. Nine months after therapy, symptoms were almost totally resolved. In order to prevent similar difficulties of differential diagnosis, biopsy materials should be sent for aerobic, tuberculosis and fungal cultivation, as well as pathological examination, in order not to miss infectious diseases from the aetiology. |
| first_indexed | 2024-04-10T13:37:54Z |
| format | Article |
| id | doaj.art-68155afa837c4775a5e29c2f55bd5cc1 |
| institution | Directory Open Access Journal |
| issn | 2667-7474 |
| language | English |
| last_indexed | 2024-04-10T13:37:54Z |
| publishDate | 2013-09-01 |
| publisher | Galenos Yayincilik |
| record_format | Article |
| series | Turkish Archives of Otorhinolaryngology |
| spelling | doaj.art-68155afa837c4775a5e29c2f55bd5cc12023-02-15T16:11:20ZengGalenos YayincilikTurkish Archives of Otorhinolaryngology2667-74742013-09-01513879010.5152/tao.2013.2213049054Difficulty of Differential Diagnosis: Granulomatous Diseases of Nasal Cavity and Paranasal SinusesOnur Ergün0Cavid Cabbarzade1Rıza Önder Günaydın2Serdar Özer3Nilda Süslü4 Department of Otorhinolaryngology and Head and Neck, Faculty of Medicine, Hacettepe University, Ankara, Turkey Department of Otorhinolaryngology and Head and Neck, Faculty of Medicine, Hacettepe University, Ankara, Turkey Department of Otorhinolaryngology and Head and Neck, Faculty of Medicine, Hacettepe University, Ankara, Turkey Department of Otorhinolaryngology and Head and Neck, Faculty of Medicine, Hacettepe University, Ankara, Turkey Department of Otorhinolaryngology and Head and Neck, Faculty of Medicine, Hacettepe University, Ankara, Turkey Infectious diseases are important causes of granulomatous diseases of the nasal cavity and paranasal sinuses. The most frequent bacterial agents responsible for granulomatous infections are Mycobacterium species (spp.) and Actinomyces spp. In the case of fungal pathogens, Aspergillus spp. are the most frequent. Mucor spp., Cryptococcus spp. and Histoplasma spp. are the other fungal microorganisms causing granulomatous reactions. In this case report, a patient suffering from a chronic nasal cavity lesion for 4 years with a recently developed premaxillary skin lesion is presented. Despite many biopsies having been performed and pathological studies conducted, a definitive diagnosis and an effective treatment could not be achieved. Finally, Aspergillus growth was observed in the fungal growth media when the material of the last skin biopsy was sent to microbiology as well as pathology. The patient was diagnosed as “chronic nasal fungal infection” and voricanozole treatment was initiated. Nine months after therapy, symptoms were almost totally resolved. In order to prevent similar difficulties of differential diagnosis, biopsy materials should be sent for aerobic, tuberculosis and fungal cultivation, as well as pathological examination, in order not to miss infectious diseases from the aetiology. http://turkarchotolaryngol.net/archives/archive-detail/article-preview/difficulty-of-differential-diagnosis-granulomatous/43422 aspergillusnasal cavityfungal infectiongranulomatous disease |
| spellingShingle | Onur Ergün Cavid Cabbarzade Rıza Önder Günaydın Serdar Özer Nilda Süslü Difficulty of Differential Diagnosis: Granulomatous Diseases of Nasal Cavity and Paranasal Sinuses Turkish Archives of Otorhinolaryngology aspergillus nasal cavity fungal infection granulomatous disease |
| title | Difficulty of Differential Diagnosis: Granulomatous Diseases of Nasal Cavity and Paranasal Sinuses |
| title_full | Difficulty of Differential Diagnosis: Granulomatous Diseases of Nasal Cavity and Paranasal Sinuses |
| title_fullStr | Difficulty of Differential Diagnosis: Granulomatous Diseases of Nasal Cavity and Paranasal Sinuses |
| title_full_unstemmed | Difficulty of Differential Diagnosis: Granulomatous Diseases of Nasal Cavity and Paranasal Sinuses |
| title_short | Difficulty of Differential Diagnosis: Granulomatous Diseases of Nasal Cavity and Paranasal Sinuses |
| title_sort | difficulty of differential diagnosis granulomatous diseases of nasal cavity and paranasal sinuses |
| topic | aspergillus nasal cavity fungal infection granulomatous disease |
| url |
http://turkarchotolaryngol.net/archives/archive-detail/article-preview/difficulty-of-differential-diagnosis-granulomatous/43422
|
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