Evaluation of Spleen Stiffness in Young Healthy Volunteers Using Magnetic Resonance Elastography
Purpose: Magnetic resonance elastography (MRE) has been established as the most accurate noninvasive technique for diagnosing liver fibrosis. Recent publications have suggested that the measurement of splenic stiffness is useful in setting where portal hypertension may be present. The goal of the cu...
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MDPI AG
2023-08-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/17/2738 |
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| author | Marzanna Obrzut Vitaliy Atamaniuk Richard L. Ehman Meng Yin Marian Cholewa Krzysztof Gutkowski Wojciech Domka Dorota Ozga Bogdan Obrzut |
| author_facet | Marzanna Obrzut Vitaliy Atamaniuk Richard L. Ehman Meng Yin Marian Cholewa Krzysztof Gutkowski Wojciech Domka Dorota Ozga Bogdan Obrzut |
| author_sort | Marzanna Obrzut |
| collection | DOAJ |
| description | Purpose: Magnetic resonance elastography (MRE) has been established as the most accurate noninvasive technique for diagnosing liver fibrosis. Recent publications have suggested that the measurement of splenic stiffness is useful in setting where portal hypertension may be present. The goal of the current study was to compile normative data for MRE-assessed stiffness measurements of the spleen in young adults. Materials and Methods: A total of 100 healthy young Caucasian volunteers (65 females and 35 males) in the age range of 20 to 32 years were enrolled in this study. The participants reported no history of chronic spleen and liver disease, normal alcohol consumption, and a normal diet. The MRE data were acquired by using a 1.5 T whole-body scanner and a 2D GRE pulse sequence with 60 Hz excitation. Spleen stiffness was calculated as a weighted mean of stiffness values in the regions of interest manually drawn by the radiologist on three to five spleen slices. Results: Mean spleen stiffness was 5.09 ± 0.65 kPa for the whole group. Male volunteers had slightly higher splenic stiffness compared to females: 5.28 ± 0.78 vs. 4.98 ± 0.51 kPa, however, this difference was not statistically significant (<i>p</i> = 0.12). Spleen stiffness did not correlate with spleen fat content and liver stiffness but a statistically significant correlation with spleen volume was found. Conclusions: The findings of this study provide normative values for 2D MRE-based measurement of spleen stiffness in young adults, a basis for assessing the value of this biomarker in young patients with portal system pathologies. |
| first_indexed | 2024-03-10T23:25:43Z |
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| last_indexed | 2024-03-10T23:25:43Z |
| publishDate | 2023-08-01 |
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| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-681768d4ca0d4e88a8307f1a892f24642023-11-19T07:58:53ZengMDPI AGDiagnostics2075-44182023-08-011317273810.3390/diagnostics13172738Evaluation of Spleen Stiffness in Young Healthy Volunteers Using Magnetic Resonance ElastographyMarzanna Obrzut0Vitaliy Atamaniuk1Richard L. Ehman2Meng Yin3Marian Cholewa4Krzysztof Gutkowski5Wojciech Domka6Dorota Ozga7Bogdan Obrzut8Institute of Health Sciences, Medical College, University of Rzeszow, Warzywna 1a, 35-310 Rzeszow, PolandDepartment of Biophysics, Institute of Physics, College of Natural Sciences, University of Rzeszow, Prof. Stanisława Pigonia Str. 1, 35-310 Rzeszow, PolandDepartment of Radiology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USADepartment of Radiology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USADepartment of Biophysics, Institute of Physics, College of Natural Sciences, University of Rzeszow, Prof. Stanisława Pigonia Str. 1, 35-310 Rzeszow, PolandInstitute of Medical Sciences, Medical College, University of Rzeszow, Rejtana 16C, 35-959 Rzeszow, PolandDepartment of Otolaryngology, Institute of Medical Sciences, Medical College, University of Rzeszow, Rejtana 16C, 35-959 Rzeszow, PolandInstitute of Health Sciences, Medical College, University of Rzeszow, Warzywna 1a, 35-310 Rzeszow, PolandDepartment of Obstetrics and Gynecology, Institute of Medical Sciences, Medical College, University of Rzeszow, Rejtana 16C, 35-959 Rzeszow, PolandPurpose: Magnetic resonance elastography (MRE) has been established as the most accurate noninvasive technique for diagnosing liver fibrosis. Recent publications have suggested that the measurement of splenic stiffness is useful in setting where portal hypertension may be present. The goal of the current study was to compile normative data for MRE-assessed stiffness measurements of the spleen in young adults. Materials and Methods: A total of 100 healthy young Caucasian volunteers (65 females and 35 males) in the age range of 20 to 32 years were enrolled in this study. The participants reported no history of chronic spleen and liver disease, normal alcohol consumption, and a normal diet. The MRE data were acquired by using a 1.5 T whole-body scanner and a 2D GRE pulse sequence with 60 Hz excitation. Spleen stiffness was calculated as a weighted mean of stiffness values in the regions of interest manually drawn by the radiologist on three to five spleen slices. Results: Mean spleen stiffness was 5.09 ± 0.65 kPa for the whole group. Male volunteers had slightly higher splenic stiffness compared to females: 5.28 ± 0.78 vs. 4.98 ± 0.51 kPa, however, this difference was not statistically significant (<i>p</i> = 0.12). Spleen stiffness did not correlate with spleen fat content and liver stiffness but a statistically significant correlation with spleen volume was found. Conclusions: The findings of this study provide normative values for 2D MRE-based measurement of spleen stiffness in young adults, a basis for assessing the value of this biomarker in young patients with portal system pathologies.https://www.mdpi.com/2075-4418/13/17/2738magnetic resonance elastographytissue stiffnessnormative values |
| spellingShingle | Marzanna Obrzut Vitaliy Atamaniuk Richard L. Ehman Meng Yin Marian Cholewa Krzysztof Gutkowski Wojciech Domka Dorota Ozga Bogdan Obrzut Evaluation of Spleen Stiffness in Young Healthy Volunteers Using Magnetic Resonance Elastography Diagnostics magnetic resonance elastography tissue stiffness normative values |
| title | Evaluation of Spleen Stiffness in Young Healthy Volunteers Using Magnetic Resonance Elastography |
| title_full | Evaluation of Spleen Stiffness in Young Healthy Volunteers Using Magnetic Resonance Elastography |
| title_fullStr | Evaluation of Spleen Stiffness in Young Healthy Volunteers Using Magnetic Resonance Elastography |
| title_full_unstemmed | Evaluation of Spleen Stiffness in Young Healthy Volunteers Using Magnetic Resonance Elastography |
| title_short | Evaluation of Spleen Stiffness in Young Healthy Volunteers Using Magnetic Resonance Elastography |
| title_sort | evaluation of spleen stiffness in young healthy volunteers using magnetic resonance elastography |
| topic | magnetic resonance elastography tissue stiffness normative values |
| url | https://www.mdpi.com/2075-4418/13/17/2738 |
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