Circulating microRNAs improve bacterial infection diagnosis and overall survival prediction in acute decompensation of liver cirrhosis
Summary: Bacterial infections are the most frequent precipitating event in patients with acute decompensation of cirrhosis (AD) and are associated with high mortality. Early diagnosis is challenging due to cirrhosis-related systemic inflammation. Here we investigated the potential of circulating mic...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223015043 |
| _version_ | 1827877514899357696 |
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| author | Yasmina Chouik Fanny Lebossé Marie-Laure Plissonnier Jean-Christophe Lega Pierre Pradat Teresa Antonini Miroslava Subic Kerstin Hartig-Lavie Domitille Erard François Villeret Céline Guichon Audrey Payancé Sylvie Radenne Pierre-Emmanuel Rautou Fabien Zoulim Massimo Levrero |
| author_facet | Yasmina Chouik Fanny Lebossé Marie-Laure Plissonnier Jean-Christophe Lega Pierre Pradat Teresa Antonini Miroslava Subic Kerstin Hartig-Lavie Domitille Erard François Villeret Céline Guichon Audrey Payancé Sylvie Radenne Pierre-Emmanuel Rautou Fabien Zoulim Massimo Levrero |
| author_sort | Yasmina Chouik |
| collection | DOAJ |
| description | Summary: Bacterial infections are the most frequent precipitating event in patients with acute decompensation of cirrhosis (AD) and are associated with high mortality. Early diagnosis is challenging due to cirrhosis-related systemic inflammation. Here we investigated the potential of circulating microRNAs to diagnose bacterial infections and predict survival in cirrhotic patients with AD. High throughput profiling of circulating microRNAs was performed using the Nanostring technology in 57 AD patients and 24 patients with compensated cirrhosis (CC). Circulating miRs profiling showed that: (a) miRs differentially detected in AD vs. CC were mostly down-regulated; (b) a composite score including absolute neutrophil count, C reactive protein and miR-362-3p could diagnose bacterial infection with an excellent performance (AUC of 0.825 [95% CI = 0.671–0.980; p < 0.001]); (c) a composite score including miR-382-5p, miR-592 and MELD-Na improved 6-month survival prediction. Circulating miRs are strongly dysregulated in patients with AD and may help to improve bacterial infection diagnosis and survival prediction. |
| first_indexed | 2024-03-12T17:38:40Z |
| format | Article |
| id | doaj.art-681a2a68d7d84002818a7c1dd208e296 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-12T17:38:40Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-681a2a68d7d84002818a7c1dd208e2962023-08-04T05:51:03ZengElsevieriScience2589-00422023-08-01268107427Circulating microRNAs improve bacterial infection diagnosis and overall survival prediction in acute decompensation of liver cirrhosisYasmina Chouik0Fanny Lebossé1Marie-Laure Plissonnier2Jean-Christophe Lega3Pierre Pradat4Teresa Antonini5Miroslava Subic6Kerstin Hartig-Lavie7Domitille Erard8François Villeret9Céline Guichon10Audrey Payancé11Sylvie Radenne12Pierre-Emmanuel Rautou13Fabien Zoulim14Massimo Levrero15Cancer Research Center of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Lyon, France; Department of Hepatology, Hôpital Croix-Rousse, Hospices Civils de Lyon, Lyon, France; University of Lyon Claude Bernard 1 (UCLB1), Lyon, France; Corresponding authorCancer Research Center of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Lyon, France; Department of Hepatology, Hôpital Croix-Rousse, Hospices Civils de Lyon, Lyon, France; University of Lyon Claude Bernard 1 (UCLB1), Lyon, FranceCancer Research Center of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Lyon, FranceDepartment of Internal Medicine, Hôpital Lyon Sud, Hospices Civils de Lyon, Lyon, FranceClinical Research Center, GHN, Hospices Civils de Lyon, Lyon, FranceDepartment of Hepatology, Hôpital Croix-Rousse, Hospices Civils de Lyon, Lyon, FranceUniversity of Lyon Claude Bernard 1 (UCLB1), Lyon, FranceDepartment of Hepatology, Hôpital Croix-Rousse, Hospices Civils de Lyon, Lyon, FranceDepartment of Hepatology, Hôpital Croix-Rousse, Hospices Civils de Lyon, Lyon, FranceDepartment of Hepatology, Hôpital Croix-Rousse, Hospices Civils de Lyon, Lyon, France; University of Lyon Claude Bernard 1 (UCLB1), Lyon, FranceDepartment of Anesthesiology and Intensive Care, Hôpital Croix-Rousse, Hospices Civils de Lyon, Lyon, FranceUniversité Paris-Cité, Inserm, Centre de recherche sur l’inflammation, UMR 1149, Paris, FranceDepartment of Hepatology, Hôpital Croix-Rousse, Hospices Civils de Lyon, Lyon, FranceUniversité Paris-Cité, Inserm, Centre de recherche sur l’inflammation, UMR 1149, Paris, France; Service d'Hépatologie, AP-HP, Hôpital Beaujon, DMU DIGEST, Centre de Référence des Maladies Vasculaires du Foie, FILFOIE, ERN RARE-LIVER, Clichy, FranceCancer Research Center of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Lyon, France; Department of Hepatology, Hôpital Croix-Rousse, Hospices Civils de Lyon, Lyon, France; University of Lyon Claude Bernard 1 (UCLB1), Lyon, FranceCancer Research Center of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Lyon, France; Department of Hepatology, Hôpital Croix-Rousse, Hospices Civils de Lyon, Lyon, France; University of Lyon Claude Bernard 1 (UCLB1), Lyon, France; Department of Medicine SCIAC and the Italian Institute of Technology (IIT) Center for Life Nanosciences (CLNS), University of Rome La Sapienza, Rome, Italy; Corresponding authorSummary: Bacterial infections are the most frequent precipitating event in patients with acute decompensation of cirrhosis (AD) and are associated with high mortality. Early diagnosis is challenging due to cirrhosis-related systemic inflammation. Here we investigated the potential of circulating microRNAs to diagnose bacterial infections and predict survival in cirrhotic patients with AD. High throughput profiling of circulating microRNAs was performed using the Nanostring technology in 57 AD patients and 24 patients with compensated cirrhosis (CC). Circulating miRs profiling showed that: (a) miRs differentially detected in AD vs. CC were mostly down-regulated; (b) a composite score including absolute neutrophil count, C reactive protein and miR-362-3p could diagnose bacterial infection with an excellent performance (AUC of 0.825 [95% CI = 0.671–0.980; p < 0.001]); (c) a composite score including miR-382-5p, miR-592 and MELD-Na improved 6-month survival prediction. Circulating miRs are strongly dysregulated in patients with AD and may help to improve bacterial infection diagnosis and survival prediction.http://www.sciencedirect.com/science/article/pii/S2589004223015043BacteriologyCell biology |
| spellingShingle | Yasmina Chouik Fanny Lebossé Marie-Laure Plissonnier Jean-Christophe Lega Pierre Pradat Teresa Antonini Miroslava Subic Kerstin Hartig-Lavie Domitille Erard François Villeret Céline Guichon Audrey Payancé Sylvie Radenne Pierre-Emmanuel Rautou Fabien Zoulim Massimo Levrero Circulating microRNAs improve bacterial infection diagnosis and overall survival prediction in acute decompensation of liver cirrhosis iScience Bacteriology Cell biology |
| title | Circulating microRNAs improve bacterial infection diagnosis and overall survival prediction in acute decompensation of liver cirrhosis |
| title_full | Circulating microRNAs improve bacterial infection diagnosis and overall survival prediction in acute decompensation of liver cirrhosis |
| title_fullStr | Circulating microRNAs improve bacterial infection diagnosis and overall survival prediction in acute decompensation of liver cirrhosis |
| title_full_unstemmed | Circulating microRNAs improve bacterial infection diagnosis and overall survival prediction in acute decompensation of liver cirrhosis |
| title_short | Circulating microRNAs improve bacterial infection diagnosis and overall survival prediction in acute decompensation of liver cirrhosis |
| title_sort | circulating micrornas improve bacterial infection diagnosis and overall survival prediction in acute decompensation of liver cirrhosis |
| topic | Bacteriology Cell biology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223015043 |
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