The influence of oral cimetidine administration on creatinine clearance in chilren with chronic renal failure: A preliminary study
Background Serum creatinine and creatinine clearance are used to assess glomerular filtration rate but have a major disadvantage since a variable amount of creatinine is secreted in the proximal tubule. This may cause an unpredictable overestimation of GFR. Tubular creatinine secretion can be blocke...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Indonesian Pediatric Society Publishing House
2016-10-01
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| Series: | Paediatrica Indonesiana |
| Subjects: | |
| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/791 |
| Summary: | Background Serum creatinine and creatinine clearance are used
to assess glomerular filtration rate but have a major disadvantage
since a variable amount of creatinine is secreted in the proximal
tubule. This may cause an unpredictable overestimation of GFR.
Tubular creatinine secretion can be blocked by cimetidine through
competitive inhibition of cation transport in the proximal tubular
luminal membrane.
Objective Cimetidine administration might improve the reliability
of creatinine as a marker of glomerular filtration.
Methods A preliminary study with a one-group pretest-posttest
design in 11 children with chronic renal failure. Serum cystatin C
level as reference value was compared with creatinine clearance
measured before and after oral ingestion of cimetidine. The dose
of cimetidine was adjusted with the GFR using Schwartz formula.
Statistical evaluation was done with the Wilcoxon signed ranks
test.
Result The mean creatinine clearance before cimetidine adminis-
tration was 27.4 (SD 14.6) ml/minute/1.73 m 2 BSA, and decreased
after cimetidine to 21.1 (SD 13,1) ml/minute/1.73 m 2 BSA (p=0.015).
Conclusion Oral cimetidine was effective in inhibiting creatinine
tubular secretion. This study could not prove that cimetidine im-
proves the accuracy of creatinine clearance |
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| ISSN: | 0030-9311 2338-476X |