Implications of Exposure to Air Pollution on Male Reproduction: The Role of Oxidative Stress
Air pollution, either from indoor (household) or outdoor (ambient) sources, occurs when there is presence of respirable particles in the form of chemical, physical, or biological agents that modify the natural features of the atmosphere or environment. Today, almost 2.4 billion people are exposed to...
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| Format: | Article |
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MDPI AG
2024-01-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/13/1/64 |
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| author | Temidayo S. Omolaoye Bongekile T. Skosana Lisa Marie Ferguson Yashthi Ramsunder Bashir M. Ayad Stefan S. Du Plessis |
| author_facet | Temidayo S. Omolaoye Bongekile T. Skosana Lisa Marie Ferguson Yashthi Ramsunder Bashir M. Ayad Stefan S. Du Plessis |
| author_sort | Temidayo S. Omolaoye |
| collection | DOAJ |
| description | Air pollution, either from indoor (household) or outdoor (ambient) sources, occurs when there is presence of respirable particles in the form of chemical, physical, or biological agents that modify the natural features of the atmosphere or environment. Today, almost 2.4 billion people are exposed to hazardous levels of indoor pollution, while 99% of the global population breathes air pollutants that exceed the World Health Organization guideline limits. It is not surprising that air pollution is the world’s leading environmental cause of diseases and contributes greatly to the global burden of diseases. Upon entry, air pollutants can cause an increase in reactive oxygen species (ROS) production by undergoing oxidation to generate quinones, which further act as oxidizing agents to yield more ROS. Excessive production of ROS can cause oxidative stress, induce lipid peroxidation, enhance the binding of polycyclic aromatic hydrocarbons (PAHs) to their receptors, or bind to PAH to cause DNA strand breaks. The continuous and prolonged exposure to air pollutants is associated with the development or exacerbation of pathologies such as acute or chronic respiratory and cardiovascular diseases, neurodegenerative and skin diseases, and even reduced fertility potential. Males and females contribute to infertility equally, and exposure to air pollutants can negatively affect reproduction. In this review, emphasis will be placed on the implications of exposure to air pollutants on male fertility potential, bringing to light its effects on semen parameters (basic and advanced) and male sexual health. This study will also touch on the clinical implications of air pollution on male reproduction while highlighting the role of oxidative stress. |
| first_indexed | 2024-03-08T11:07:16Z |
| format | Article |
| id | doaj.art-681af3f8185041469276394f496641aa |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-08T11:07:16Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-681af3f8185041469276394f496641aa2024-01-26T14:40:58ZengMDPI AGAntioxidants2076-39212024-01-011316410.3390/antiox13010064Implications of Exposure to Air Pollution on Male Reproduction: The Role of Oxidative StressTemidayo S. Omolaoye0Bongekile T. Skosana1Lisa Marie Ferguson2Yashthi Ramsunder3Bashir M. Ayad4Stefan S. Du Plessis5College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai P.O. Box 505055, United Arab EmiratesDivision of Medical Physiology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town 7602, South AfricaDivision of Medical Physiology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town 7602, South AfricaDivision of Medical Physiology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town 7602, South AfricaDepartment of Physiology, Faculty of Medicine, Misurata University, Misratah P.O. Box 2478, LibyaCollege of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai P.O. Box 505055, United Arab EmiratesAir pollution, either from indoor (household) or outdoor (ambient) sources, occurs when there is presence of respirable particles in the form of chemical, physical, or biological agents that modify the natural features of the atmosphere or environment. Today, almost 2.4 billion people are exposed to hazardous levels of indoor pollution, while 99% of the global population breathes air pollutants that exceed the World Health Organization guideline limits. It is not surprising that air pollution is the world’s leading environmental cause of diseases and contributes greatly to the global burden of diseases. Upon entry, air pollutants can cause an increase in reactive oxygen species (ROS) production by undergoing oxidation to generate quinones, which further act as oxidizing agents to yield more ROS. Excessive production of ROS can cause oxidative stress, induce lipid peroxidation, enhance the binding of polycyclic aromatic hydrocarbons (PAHs) to their receptors, or bind to PAH to cause DNA strand breaks. The continuous and prolonged exposure to air pollutants is associated with the development or exacerbation of pathologies such as acute or chronic respiratory and cardiovascular diseases, neurodegenerative and skin diseases, and even reduced fertility potential. Males and females contribute to infertility equally, and exposure to air pollutants can negatively affect reproduction. In this review, emphasis will be placed on the implications of exposure to air pollutants on male fertility potential, bringing to light its effects on semen parameters (basic and advanced) and male sexual health. This study will also touch on the clinical implications of air pollution on male reproduction while highlighting the role of oxidative stress.https://www.mdpi.com/2076-3921/13/1/64air pollutionmale infertilitysemen abnormalitiesoxidative stressmale sexual health |
| spellingShingle | Temidayo S. Omolaoye Bongekile T. Skosana Lisa Marie Ferguson Yashthi Ramsunder Bashir M. Ayad Stefan S. Du Plessis Implications of Exposure to Air Pollution on Male Reproduction: The Role of Oxidative Stress Antioxidants air pollution male infertility semen abnormalities oxidative stress male sexual health |
| title | Implications of Exposure to Air Pollution on Male Reproduction: The Role of Oxidative Stress |
| title_full | Implications of Exposure to Air Pollution on Male Reproduction: The Role of Oxidative Stress |
| title_fullStr | Implications of Exposure to Air Pollution on Male Reproduction: The Role of Oxidative Stress |
| title_full_unstemmed | Implications of Exposure to Air Pollution on Male Reproduction: The Role of Oxidative Stress |
| title_short | Implications of Exposure to Air Pollution on Male Reproduction: The Role of Oxidative Stress |
| title_sort | implications of exposure to air pollution on male reproduction the role of oxidative stress |
| topic | air pollution male infertility semen abnormalities oxidative stress male sexual health |
| url | https://www.mdpi.com/2076-3921/13/1/64 |
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