Cochlear dysfunction and microvascular complications in patients with type 1 diabetes mellitus
Abstract Sensorineural hearing impairment has been associated with DM, and it is probably linked to the same pathophysiological mechanisms as well-established in microvascular diabetes complications. The study of otoacoustic emissions (OAEs) is useful to identify subclinical cochlear dysfunction. Th...
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-11-01
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| Series: | Diabetology & Metabolic Syndrome |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13098-018-0380-z |
| _version_ | 1819068605299425280 |
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| author | João Soares Felício Lilian de Souza d’Albuquerque Silva Carlliane Lima e Lins Pinto Martins João Felício Abrahão Neto Manuela Nascimento de Lemos Fabrício de Souza Resende Wanderson Maia da Silva Angélica Leite de Alcântara Maria Clara Neres Iunes de Oliveira Norberto Jorge Kzan de Souza Neto Isabela Imbelloni Farias de Franco Nathalie Abdallah Zahalan Luísa Correa Janaú Ana Carolina Contente Braga de Souza Flavia Marques Santos Natércia Neves Marques de Queiroz Neyla Arroyo Lara Mourão Márcia Costa dos Santos Karem Miléo Felício Franciane Trindade Cunha de Melo |
| author_facet | João Soares Felício Lilian de Souza d’Albuquerque Silva Carlliane Lima e Lins Pinto Martins João Felício Abrahão Neto Manuela Nascimento de Lemos Fabrício de Souza Resende Wanderson Maia da Silva Angélica Leite de Alcântara Maria Clara Neres Iunes de Oliveira Norberto Jorge Kzan de Souza Neto Isabela Imbelloni Farias de Franco Nathalie Abdallah Zahalan Luísa Correa Janaú Ana Carolina Contente Braga de Souza Flavia Marques Santos Natércia Neves Marques de Queiroz Neyla Arroyo Lara Mourão Márcia Costa dos Santos Karem Miléo Felício Franciane Trindade Cunha de Melo |
| author_sort | João Soares Felício |
| collection | DOAJ |
| description | Abstract Sensorineural hearing impairment has been associated with DM, and it is probably linked to the same pathophysiological mechanisms as well-established in microvascular diabetes complications. The study of otoacoustic emissions (OAEs) is useful to identify subclinical cochlear dysfunction. Therefore, the aim of this study was to evaluate the association between abnormal OAEs responses, diabetic kidney disease (DKD) and diabetic cardiac autonomic neuropathy (CAN). We performed a cross-sectional study with 37 type 1 DM patients without auditory symptoms, submitted to the study of Distortion Product Otoacoustic Emissions (DPOAEs) and screened for DKD and CAN. The otoacoustic emissions responses were considered abnormal in 27/37 (73%) patients. A correlation was found between abnormal OAEs responses and presence of DKD (r = 0.36, p < 0.05), and 14/16 (88%) patients with a lower amplitude of OAEs in 8 kHz frequency band presented DKD. Abnormal OAEs responses in the 6 kHz frequency band were correlated with the presence (r = 0.41, p = 0.01) and severity of CAN (r = 0.44, p < 0.001). Additionally, 7/9 (78%) patients with abnormal OAE responses in this frequency also presented abnormal CAN scores. Our results suggest that abnormal otoacoustic emissions responses in high frequency bands are associated with diabetes microvascular complications and could be a risk marker for DKD and CAN, presenting low sensitivity and high specificity. Therefore, assuming that hearing impairment is a pre-clinical stage of hearing loss, performing distortion product otoacoustic emissions in T1DM patients with microvascular complications could be useful to identify those who would be benefit with regular audiologic follow up and tighter diabetes control. |
| first_indexed | 2024-12-21T16:36:48Z |
| format | Article |
| id | doaj.art-681ba00b5c694479b2c876c60d5dc9b6 |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-12-21T16:36:48Z |
| publishDate | 2018-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-681ba00b5c694479b2c876c60d5dc9b62022-12-21T18:57:12ZengBMCDiabetology & Metabolic Syndrome1758-59962018-11-011011910.1186/s13098-018-0380-zCochlear dysfunction and microvascular complications in patients with type 1 diabetes mellitusJoão Soares Felício0Lilian de Souza d’Albuquerque Silva1Carlliane Lima e Lins Pinto Martins2João Felício Abrahão Neto3Manuela Nascimento de Lemos4Fabrício de Souza Resende5Wanderson Maia da Silva6Angélica Leite de Alcântara7Maria Clara Neres Iunes de Oliveira8Norberto Jorge Kzan de Souza Neto9Isabela Imbelloni Farias de Franco10Nathalie Abdallah Zahalan11Luísa Correa Janaú12Ana Carolina Contente Braga de Souza13Flavia Marques Santos14Natércia Neves Marques de Queiroz15Neyla Arroyo Lara Mourão16Márcia Costa dos Santos17Karem Miléo Felício18Franciane Trindade Cunha de Melo19Endocrinology Division - Programa de Pós-Graduação em Oncologia e Ciências Médicas, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division - Programa de Pós-Graduação em Oncologia e Ciências Médicas, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division - Programa de Pós-Graduação em Oncologia e Ciências Médicas, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division - Programa de Pós-Graduação em Oncologia e Ciências Médicas, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division - Programa de Pós-Graduação em Oncologia e Ciências Médicas, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division - Programa de Pós-Graduação em Oncologia e Ciências Médicas, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division - Programa de Pós-Graduação em Oncologia e Ciências Médicas, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division - Programa de Pós-Graduação em Oncologia e Ciências Médicas, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division - Programa de Pós-Graduação em Oncologia e Ciências Médicas, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division - Programa de Pós-Graduação em Oncologia e Ciências Médicas, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division - Programa de Pós-Graduação em Oncologia e Ciências Médicas, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division - Programa de Pós-Graduação em Oncologia e Ciências Médicas, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division - Programa de Pós-Graduação em Oncologia e Ciências Médicas, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division - Programa de Pós-Graduação em Oncologia e Ciências Médicas, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division - Programa de Pós-Graduação em Oncologia e Ciências Médicas, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division - Programa de Pós-Graduação em Oncologia e Ciências Médicas, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division - Programa de Pós-Graduação em Oncologia e Ciências Médicas, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division - Programa de Pós-Graduação em Oncologia e Ciências Médicas, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division - Programa de Pós-Graduação em Oncologia e Ciências Médicas, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division - Programa de Pós-Graduação em Oncologia e Ciências Médicas, University Hospital João de Barros Barreto, Federal University of ParáAbstract Sensorineural hearing impairment has been associated with DM, and it is probably linked to the same pathophysiological mechanisms as well-established in microvascular diabetes complications. The study of otoacoustic emissions (OAEs) is useful to identify subclinical cochlear dysfunction. Therefore, the aim of this study was to evaluate the association between abnormal OAEs responses, diabetic kidney disease (DKD) and diabetic cardiac autonomic neuropathy (CAN). We performed a cross-sectional study with 37 type 1 DM patients without auditory symptoms, submitted to the study of Distortion Product Otoacoustic Emissions (DPOAEs) and screened for DKD and CAN. The otoacoustic emissions responses were considered abnormal in 27/37 (73%) patients. A correlation was found between abnormal OAEs responses and presence of DKD (r = 0.36, p < 0.05), and 14/16 (88%) patients with a lower amplitude of OAEs in 8 kHz frequency band presented DKD. Abnormal OAEs responses in the 6 kHz frequency band were correlated with the presence (r = 0.41, p = 0.01) and severity of CAN (r = 0.44, p < 0.001). Additionally, 7/9 (78%) patients with abnormal OAE responses in this frequency also presented abnormal CAN scores. Our results suggest that abnormal otoacoustic emissions responses in high frequency bands are associated with diabetes microvascular complications and could be a risk marker for DKD and CAN, presenting low sensitivity and high specificity. Therefore, assuming that hearing impairment is a pre-clinical stage of hearing loss, performing distortion product otoacoustic emissions in T1DM patients with microvascular complications could be useful to identify those who would be benefit with regular audiologic follow up and tighter diabetes control.http://link.springer.com/article/10.1186/s13098-018-0380-zType 1 diabetes mellitusCochlear dysfunctionSensorineural hearing lossOtoacoustic emissionsDiabetic kidney diseaseCardiac autonomic neuropathy |
| spellingShingle | João Soares Felício Lilian de Souza d’Albuquerque Silva Carlliane Lima e Lins Pinto Martins João Felício Abrahão Neto Manuela Nascimento de Lemos Fabrício de Souza Resende Wanderson Maia da Silva Angélica Leite de Alcântara Maria Clara Neres Iunes de Oliveira Norberto Jorge Kzan de Souza Neto Isabela Imbelloni Farias de Franco Nathalie Abdallah Zahalan Luísa Correa Janaú Ana Carolina Contente Braga de Souza Flavia Marques Santos Natércia Neves Marques de Queiroz Neyla Arroyo Lara Mourão Márcia Costa dos Santos Karem Miléo Felício Franciane Trindade Cunha de Melo Cochlear dysfunction and microvascular complications in patients with type 1 diabetes mellitus Diabetology & Metabolic Syndrome Type 1 diabetes mellitus Cochlear dysfunction Sensorineural hearing loss Otoacoustic emissions Diabetic kidney disease Cardiac autonomic neuropathy |
| title | Cochlear dysfunction and microvascular complications in patients with type 1 diabetes mellitus |
| title_full | Cochlear dysfunction and microvascular complications in patients with type 1 diabetes mellitus |
| title_fullStr | Cochlear dysfunction and microvascular complications in patients with type 1 diabetes mellitus |
| title_full_unstemmed | Cochlear dysfunction and microvascular complications in patients with type 1 diabetes mellitus |
| title_short | Cochlear dysfunction and microvascular complications in patients with type 1 diabetes mellitus |
| title_sort | cochlear dysfunction and microvascular complications in patients with type 1 diabetes mellitus |
| topic | Type 1 diabetes mellitus Cochlear dysfunction Sensorineural hearing loss Otoacoustic emissions Diabetic kidney disease Cardiac autonomic neuropathy |
| url | http://link.springer.com/article/10.1186/s13098-018-0380-z |
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