<sec><title>INTRODUCTION:</title> Amphotericin B, azole or sulfamide drugs are used for treatment of patients with paracoccidioidomycosis. Among the azole drugs, voriconazole was active in vitro against Paracoccidioides brasiliensis and showed efficacy in the treatment of patients...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
2013-01-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000100079 |
| _version_ | 1811340733907468288 |
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| author | Daniela Silva Granzoto Lúcia Helena Vitali Roberto Martinez |
| author_facet | Daniela Silva Granzoto Lúcia Helena Vitali Roberto Martinez |
| author_sort | Daniela Silva Granzoto |
| collection | DOAJ |
| description | <sec><title>INTRODUCTION:</title> Amphotericin B, azole or sulfamide drugs are used for treatment of patients with paracoccidioidomycosis. Among the azole drugs, voriconazole was active in vitro against Paracoccidioides brasiliensis and showed efficacy in the treatment of patients infected with this fungus.In the present study the antifungal activity of voriconazole and of other drugs was compared in a rat model of paracoccidioidomycosis. </sec><sec><title>METHODS:</title> Wistar rats were inoculated intravenously with the BOAS strain of P. brasiliensis and antifungal drugs were administered to the animals by gavage at the following doses (mg/kg weight/day): voriconazole (5 to 20), ketoconazole (12 to 15), fluconazole (6), itraconazole (4), and sulfamethoxazole-trimethoprim (120 to 150). The antifungal activity of the drugs was assessed by determining the P. brasiliensis colony forming units in the lungs and spleen of the animals at the end of treatment and by a survival study. </sec><sec><title>RESULTS:</title> Voriconazole reduced the total tissue fungal burden of P. brasiliensis, particularly at doses of ≥10mg/kg weight/day but its antifungal activity was less intense than that of fluconazole, itraconazole and sulfamethoxazole-trimethoprim. The mean survival of animals treated with the last three drugs, 29.1±10.7, 26.1± 10.1 and 28.4±9.6 days, respectively, was higher than that achieved with voriconazole 10mg/kg weight/day (18.5±8.3 days) and that observed in untreated animals (15.7±3.6 days). </sec><sec><title>CONCLUSIONS:</title> At doses similar to those used for clinical treatment, voriconazole showed lower antifungal activity in experimental rat paracoccidioidomycosis than that obtained with itraconazole and sulfamethoxazole-trimethoprim.</sec> |
| first_indexed | 2024-04-13T18:46:15Z |
| format | Article |
| id | doaj.art-681c96c35ccb4074a916533154363c82 |
| institution | Directory Open Access Journal |
| issn | 0037-8682 1678-9849 |
| language | English |
| last_indexed | 2024-04-13T18:46:15Z |
| publishDate | 2013-01-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-681c96c35ccb4074a916533154363c822022-12-22T02:34:35ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical0037-86821678-98492013-01-014617983Daniela Silva GranzotoLúcia Helena VitaliRoberto Martinez<sec><title>INTRODUCTION:</title> Amphotericin B, azole or sulfamide drugs are used for treatment of patients with paracoccidioidomycosis. Among the azole drugs, voriconazole was active in vitro against Paracoccidioides brasiliensis and showed efficacy in the treatment of patients infected with this fungus.In the present study the antifungal activity of voriconazole and of other drugs was compared in a rat model of paracoccidioidomycosis. </sec><sec><title>METHODS:</title> Wistar rats were inoculated intravenously with the BOAS strain of P. brasiliensis and antifungal drugs were administered to the animals by gavage at the following doses (mg/kg weight/day): voriconazole (5 to 20), ketoconazole (12 to 15), fluconazole (6), itraconazole (4), and sulfamethoxazole-trimethoprim (120 to 150). The antifungal activity of the drugs was assessed by determining the P. brasiliensis colony forming units in the lungs and spleen of the animals at the end of treatment and by a survival study. </sec><sec><title>RESULTS:</title> Voriconazole reduced the total tissue fungal burden of P. brasiliensis, particularly at doses of ≥10mg/kg weight/day but its antifungal activity was less intense than that of fluconazole, itraconazole and sulfamethoxazole-trimethoprim. The mean survival of animals treated with the last three drugs, 29.1±10.7, 26.1± 10.1 and 28.4±9.6 days, respectively, was higher than that achieved with voriconazole 10mg/kg weight/day (18.5±8.3 days) and that observed in untreated animals (15.7±3.6 days). </sec><sec><title>CONCLUSIONS:</title> At doses similar to those used for clinical treatment, voriconazole showed lower antifungal activity in experimental rat paracoccidioidomycosis than that obtained with itraconazole and sulfamethoxazole-trimethoprim.</sec>http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000100079ParacoccidioidomycosisParacoccidioides brasiliensisVoriconazoleItraconazoleFluconazoleSulfamethoxazole-trimethoprim |
| spellingShingle | Daniela Silva Granzoto Lúcia Helena Vitali Roberto Martinez Revista da Sociedade Brasileira de Medicina Tropical Paracoccidioidomycosis Paracoccidioides brasiliensis Voriconazole Itraconazole Fluconazole Sulfamethoxazole-trimethoprim |
| topic | Paracoccidioidomycosis Paracoccidioides brasiliensis Voriconazole Itraconazole Fluconazole Sulfamethoxazole-trimethoprim |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000100079 |