Pathological bases and clinical impact of long noncoding RNAs in prostate cancer: a new budding star
Abstract Long non-coding RNAs (lncRNAs) are functional RNAs longer than 200 nucleotides. Recent advances in the non-protein coding part of human genome analysis have discovered extensive transcription of large RNA transcripts that lack coding protein function, termed non-coding RNA (ncRNA). It is be...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-07-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12943-018-0852-7 |
| _version_ | 1819014042646216704 |
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| author | Tao Xu Chang-ming Lin Shu-qi Cheng Jie Min Li Li Xiao-ming Meng Cheng Huang Lei Zhang Zi-yu Deng Jun Li |
| author_facet | Tao Xu Chang-ming Lin Shu-qi Cheng Jie Min Li Li Xiao-ming Meng Cheng Huang Lei Zhang Zi-yu Deng Jun Li |
| author_sort | Tao Xu |
| collection | DOAJ |
| description | Abstract Long non-coding RNAs (lncRNAs) are functional RNAs longer than 200 nucleotides. Recent advances in the non-protein coding part of human genome analysis have discovered extensive transcription of large RNA transcripts that lack coding protein function, termed non-coding RNA (ncRNA). It is becoming evident that lncRNAs may be an important class of pervasive genes involved in carcinogenesis and metastasis. However, the biological and molecular mechanisms of lncRNAs in diverse diseases are not yet fully understood. Thus, it is anticipated that more efforts should be made to clarify the lncRNA world. Moreover, accumulating evidence has demonstrated that many lncRNAs are dysregulated in prostate cancer (PC) and closely related to tumorigenesis, metastasis, and prognosis or diagnosis. In this review, we will briefly outline the regulation and functional role of lncRNAs in PC. Finally, we discussed the potential of lncRNAs as prospective novel targets in PC treatment and biomarkers for PC diagnosis. |
| first_indexed | 2024-12-21T02:09:33Z |
| format | Article |
| id | doaj.art-681e953717c54c5b8d225e9254b51a9e |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-12-21T02:09:33Z |
| publishDate | 2018-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-681e953717c54c5b8d225e9254b51a9e2022-12-21T19:19:23ZengBMCMolecular Cancer1476-45982018-07-0117111710.1186/s12943-018-0852-7Pathological bases and clinical impact of long noncoding RNAs in prostate cancer: a new budding starTao Xu0Chang-ming Lin1Shu-qi Cheng2Jie Min3Li Li4Xiao-ming Meng5Cheng Huang6Lei Zhang7Zi-yu Deng8Jun Li9School of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical UniversityDepartment of Urology, The Fourth Affiliated Hospital of Anhui Medical UniversitySchool of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical UniversityDepartment of Urology, The Second Affiliated Hospital of Anhui Medical UniversitySchool of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical UniversitySchool of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical UniversitySchool of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical UniversitySchool of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical UniversityDepartment of Scientific, The Second Affiliated Hospital of Anhui Medical UniversitySchool of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical UniversityAbstract Long non-coding RNAs (lncRNAs) are functional RNAs longer than 200 nucleotides. Recent advances in the non-protein coding part of human genome analysis have discovered extensive transcription of large RNA transcripts that lack coding protein function, termed non-coding RNA (ncRNA). It is becoming evident that lncRNAs may be an important class of pervasive genes involved in carcinogenesis and metastasis. However, the biological and molecular mechanisms of lncRNAs in diverse diseases are not yet fully understood. Thus, it is anticipated that more efforts should be made to clarify the lncRNA world. Moreover, accumulating evidence has demonstrated that many lncRNAs are dysregulated in prostate cancer (PC) and closely related to tumorigenesis, metastasis, and prognosis or diagnosis. In this review, we will briefly outline the regulation and functional role of lncRNAs in PC. Finally, we discussed the potential of lncRNAs as prospective novel targets in PC treatment and biomarkers for PC diagnosis.http://link.springer.com/article/10.1186/s12943-018-0852-7Long non-coding RNAsProstate cancer (PC)BiomarkerTumorigenesis |
| spellingShingle | Tao Xu Chang-ming Lin Shu-qi Cheng Jie Min Li Li Xiao-ming Meng Cheng Huang Lei Zhang Zi-yu Deng Jun Li Pathological bases and clinical impact of long noncoding RNAs in prostate cancer: a new budding star Molecular Cancer Long non-coding RNAs Prostate cancer (PC) Biomarker Tumorigenesis |
| title | Pathological bases and clinical impact of long noncoding RNAs in prostate cancer: a new budding star |
| title_full | Pathological bases and clinical impact of long noncoding RNAs in prostate cancer: a new budding star |
| title_fullStr | Pathological bases and clinical impact of long noncoding RNAs in prostate cancer: a new budding star |
| title_full_unstemmed | Pathological bases and clinical impact of long noncoding RNAs in prostate cancer: a new budding star |
| title_short | Pathological bases and clinical impact of long noncoding RNAs in prostate cancer: a new budding star |
| title_sort | pathological bases and clinical impact of long noncoding rnas in prostate cancer a new budding star |
| topic | Long non-coding RNAs Prostate cancer (PC) Biomarker Tumorigenesis |
| url | http://link.springer.com/article/10.1186/s12943-018-0852-7 |
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